Investigation of pair-wise single-cell interactions by statistically interpreting spatial cell state correlation learned by self-supervised graph inductive bias transformer
Xiao Xiao
Abstract:Image-based spatial transcriptomics (ST) offers spatial gene expression profile at the single-cell resolution and provides information to understand intercellular communication that is critical for maintaining tissue development and organ function. Disruption of normal cell-cell interactions (CCI) can lead to disease onset and progression. Current CCI analysis methods face several limitations, including subjection to the number of measured ligand-receptor genes in image-based spatial transcriptomics, limited g… Show more
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