Investigation of oxidative stress markers and antioxidant enzymes activity in newly diagnosed type 2 diabetes patients and healthy subjects, association with IL-6 level

Sadeghabadi, Zahra Arab; Abbasalipourkabir, Roghayeh; Mohseni, Roohollah; Ziamajidi, Nasrin

doi:10.1007/s40200-019-00437-8

Cited by 23 publications

(18 citation statements)

References 17 publications

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“…We also observed a significant reduction in SOD activity in the brain, liver, and plasma of diabetic animals but a significant increment in RBC activity. These findings are consistent with research carried out with Pan and Arab Sadeghabadi results [38,52]. Reduction in SOD was also confirmed by Sadeghabadi et.…”

Section: Discussionsupporting

confidence: 93%

“…Due to prolonged hyperglycemia that induces oxidative stress [52], diabetic patients are believed to have an imbalance between ROS formation and degradation due to deficiency in their antioxidant systems [38]. This has also been confirmed using animal models [53].…”

Section: Discussionmentioning

confidence: 97%

“…Antioxidants, such as superoxide dismutase (SOD), glutathione peroxidase (GPx), sulfiredoxin and catalase (CAT), are tasked with eliminating ROS by donating an electron. Some examples of ROS include radicals like hydroxyl (OH) and superoxide anion (O2-), and non-radical species like hydrogen peroxide (H2O2) and hydrochloric acid (HCl) [38,39]. They are usually highly reactive due to one or more unpaired electron(s) in their molecular outskirt.…”

Section: Introductionmentioning

confidence: 99%

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Antioxidant and Esterases Profiling of diabetes-induced rat and tissues compartmentalisation.

Wusu

2021

JRRS

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Enormous complications associated with diabetes contribute to the therapeutic challenge confronting most of the world, including developing countries. This study was carried out to investigate diabetes mellitus on esterases and antioxidant enzymes in different tissues compartments of rats. Animals were divided into two groups of 10 animals each. The experimental group was confirmed diabetic by a single dose of streptozotocin injection (STZ, freshly dissolved in citrate buffer, pH 4.5, 50 mg/kg) intraperitoneally. In contrast, the control group was injected with citrate buffer only. Blood glucose and weight of the animals were monitored for 7 days. Blood, liver and brain were removed, and biochemical parameters determined spectrophotometrically. Diabetes produced various degrees of alterations in antioxidant defence mechanism and esterases activities that are compartment specific. Acetylcholinesterase (AChE) activity was inhibited to various extents. While AChE was inhibited to the tune of 39% in plasma, 33% in the brain and 30% in the liver, activation of the activity was observed in the red blood cell (RBC). The same trend of significant (p < 0.001) inhibition was observed with arylesterase in the plasma, brain and liver, and activation in the RBC. Diabetes induced significant (p<0.001) inhibition in catalase, Glutathione-S-transferase, and Superoxide dismutase in the brain and liver, respectively, compared to control more than the other compartments. However, activation was also observed in the RBC of these enzymes except for catalase and nitric oxide. In conclusion, distinct compartments effects of diabetes observed in this study could suggest a new approach for effective and safer therapeutics.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

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Antioxidant and Esterases Profiling of diabetes-induced rat and tissues compartmentalisation.

Wusu

2021

JRRS

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“…Hyperglycemia can induce oxidative stress via over-secretion of advanced glycation end-products (AGEs), polyols and PKCβ1/2 kinase pathway metabolites (5). Additionally, when the levels of free radicals are elevated, amount of body anti-oxidant defense system markers such as TAC and SOD reduces (6). Moreover, prolonged oxidative stress induces the secretion of in ammatory factors such as C-reactive protein (CRP) and IL-18 (7)(8)(9).…”

Section: Introductionmentioning

confidence: 99%

Dietary Quality Indices Modify the Effects of Apolipoprotein B Polymorphisms on Cardio-Metabolic Risk Factors in type 2 Diabetes Mellitus: A Cross-Sectional Study

Karimi

Sotoudeh

Rafiee

et al. 2021

Preprint

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Background: We tried to identify the interaction between dietary quality indices and apolipoprotein B Ins/Del and EcoR1 polymorphisms on cardio-metabolic risk factors in patients with type 2 diabetes mellitus (T2DM). Methods: This cross-sectional study recruited 700 adults with T2DM who visited diabetes referral centers in Tehran. The genotypes of Ins/Del and EcoR1 single nucleotide polymorphisms (SNP) were explored via polymerase chain reaction (PCR). Dietary quality index-international (DQI-I), healthy eating index-2015 (HEI-2015) and dietary phytochemical index (DPI) were calculated by semi-quantitative food frequency questionnaire (FFQ). Lipid, inflammatory, oxidative, hormonal and anthropometric variables were determined by standard methods. Results: We observed a significant interaction between DQI-I and Ins/Del SNP on leptin (P= 0.02 for crude model and P=0.01 for adjusted model (for age, physical activity, gender, smoking and alcohol intake) and 8-iso-prostaglandin F2 α (8-iso-PGF2α) (P=0.01 for both models), DPI and EcoR1 SNP on total cholesterol (TC) (P=0.03 for both models) and between Ins/Del SNP and HEI-2015 on interleukin-18 (IL-18) (P= 0.02 for crude model and P=0.03 for adjusted model). Furthermore, in crude but not in adjusted model there were close to meaningful interactions between EcoR1 SNP and DQI-I on total antioxidant capacity (TAC) (P=0.06) and between EcoR1 SNP and HEI-2015 on serum leptin (P=0.05) and superoxide dismutase (SOD) (p=0.05) levels. Conclusion: For the first time, our finding indicated that the association between DQI-I, HEI-2015 and DPI with IL-18, TC, leptin and 8-iso-PGF2α in patients with T2DM might be dependent on Ins/Del and EcoR1 variants in ApoB gene.

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“…Hyperglycemia can induce oxidative stress via over-secretion of advanced glycation endproducts (AGEs), polyols and PKCβ1/2 kinase pathway metabolites 5 . When the levels of free radicals are elevated, amount of body anti-oxidant defense system markers such as TAC and SOD reduces 6 .…”

Section: Introductionmentioning

confidence: 99%

Dietary quality indices modify the effects of apolipoprotein B polymorphisms on cardio-metabolic risk factors in type 2 diabetes mellitus

Karimi

Sotoudeh

Rafiee

et al. 2021

Preprint

View full text Add to dashboard Cite

We tried to identify the interaction between dietary quality indices and apolipoprotein B Ins/Del and EcoR1 polymorphisms on cardio-metabolic risk factors in patients with type 2 diabetes mellitus (T2DM). This cross-sectional study recruited 700 adults with T2DM in Tehran. The genotypes of Ins/Del and EcoR1 single nucleotide polymorphisms (SNP) were explored via polymerase chain reaction (PCR). Dietary quality index-international (DQI-I), healthy eating index-2015 (HEI-2015) and dietary phytochemical index (DPI) were calculated by semi-quantitative food frequency questionnaire (FFQ). In both crude and adjusted model for confounding factors, we observed significant interactions between DQI-I and Ins/Del SNP on leptin in and 8-iso-prostaglandin F2 α (8-iso-PGF2α), DPI and EcoR1 SNP on total cholesterol (TC) and between Ins/Del SNP and HEI-2015 on interleukin-18 (IL-18). Furthermore, in crude model there were close to meaningful interactions between EcoR1 SNP and DQI-I on total antioxidant capacity (TAC) and between EcoR1 SNP and HEI-2015 on serum leptin and superoxide dismutase (SOD) levels. Our finding indicated that the association between DQI-I, HEI-2015 and DPI with IL-18, TC, leptin and 8-iso-PGF2α in patients with T2DM might be dependent on Ins/Del and EcoR1 variants in ApoB gene.

show abstract

Investigation of oxidative stress markers and antioxidant enzymes activity in newly diagnosed type 2 diabetes patients and healthy subjects, association with IL-6 level

Cited by 23 publications

References 17 publications

Antioxidant and Esterases Profiling of diabetes-induced rat and tissues compartmentalisation.

Antioxidant and Esterases Profiling of diabetes-induced rat and tissues compartmentalisation.

Dietary Quality Indices Modify the Effects of Apolipoprotein B Polymorphisms on Cardio-Metabolic Risk Factors in type 2 Diabetes Mellitus: A Cross-Sectional Study

Dietary quality indices modify the effects of apolipoprotein B polymorphisms on cardio-metabolic risk factors in type 2 diabetes mellitus

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