Investigation of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio and mean platelet volume in patients with tinnitus

Ulusoy, Bülent; Bozdemir, Kazım; Akyol, Mesut; Mişe, Halil İbrahim; Kutluhan, Ahmet; Korkmaz, Mehmet

doi:10.1017/s0022215117002481

Cited by 16 publications

(20 citation statements)

References 16 publications

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“…(1) Male or female, ages 18-60 (2) Unilateral or bilateral subjective tinnitus (3) History of severe subjective tinnitus for at least 1 year (4) Severe tinnitus according to the Tinnitus Handicap Inventory (THI) questionnaire (more than 38 points) (5) undetectable etiology of tinnitus in an otolaryngology examination (6) No treatment received within the last 6 months.…”

Section: Methodsmentioning

confidence: 99%

“…The sound perceived without an external stimulus is considered to be caused by abnormal neural activity along the hearing path from the cochlear apparatus to the auditory cortex. 6 Complementary and alternative medicine treatments are often used to treat tinnitus, and one of the most frequently used options is acupuncture. 7 Acupuncture therapy in patients who have tinnitus has been described extensively in books 8 ; however, scientific literature still lacks studies that support its therapeutic efficacy.…”

Section: Introductionmentioning

confidence: 99%

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Acupuncture Treatment in Patients with Chronic Subjective Tinnitus: A Prospective, Randomized Study

Kuzucu

Karaca

2020

Medical Acupuncture

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Objective: This study investigated the effect, onset, duration of action, and short-term outcomes of acupuncture therapy for treating patients with severe chronic subjective tinnitus. Materials and Methods: This randomized controlled trial evaluated patients with chronic, idiopathic, and severe tinnitus. A total of 105 participants were divided into 2 groups using a randomization method: a study group who received verum acupuncture therapy (n = 53) and a sham acupuncture group (n = 52). Ten acupuncture sessions were given over 5 weeks. After treatment, each participant was monitored for up to 3 months according to changes on a visual analogue Scale (VAS), and Tinnitus Handicap Inventory (THI), and Pure-Tone Audiometry and Speech Discrimination (Interacoustics AC-40, Denmark) scores. Results: The VAS and THI scores were evaluated. A statistically significant difference was noted between the sham and verum acupuncture groups at post-treatment follow-up (P < 0.001). Decreases in the THI and VAS scores became significant in the second week of treatment (P < 0.001 and P < 0.001, respectively), but these scores increased again in the third month post-treatment (P < 0.001 and P < 0.001, respectively). Conclusions: Acupuncture is an effective treatment for patients with severe chronic subjective tinnitus. Patient complaints, decreased beginning at the second treatment week; however, in the third post-treatment month, the complaints reappeared. Maintenance acupuncture therapy is necessary for patients with tinnitus; this approach should be investigated in future studies.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Acupuncture Treatment in Patients with Chronic Subjective Tinnitus: A Prospective, Randomized Study

Kuzucu

Karaca

2020

Medical Acupuncture

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“…The mean PLR values were 138.24 ± 50.83 in the patient group and 127.39 ± 45.31 in the control group. There Ulusoy et al [16] showed that MPV values were significantly higher in tinnitus patients than the control group. MPV values were studied also in sudden sensorineural hearing loss (SSHL) patients and results were controversial like tinnitus patients.…”

Section: Discussionmentioning

confidence: 94%

Increased mean platelet volume in patients with vestibular migraine

Çavuş

Tanyeli

Bayır

et al. 2020

The European Research Journal

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Objectives: The purpose of this study was to investigate relation between mean platelet volume, platelet distribution width, platelet-to-lymphocyte ratio, neutrophil-to-lymphocyte ratio and vestibular migraine. Methods: This study was planned in prospective manner and conducted in Ankara Polatlı State Hospital between April 2017 and May 2018. Thirty patients diagnosed with vestibular migraine and thirty healthy, age and sex-matched subjects were enrolled to the study. Mean platelet volume, platelet distribution width, platelet count, neutrophil count and lymphocyte count in blood samples were measured. Results: The mean age of the patients with vestibular migraine was 39.90 ± 7.16 and the study group consisted of 11 males and 19 females. The mean platelet volume and platelet distribution width values in patients with vestibular migraine were significantly higher than the control group (p < 0.001). There were no difference on mean neutrophil/lymphocyte ratio and platelet/lymphocyte ratio values between patient group and control group. Conclusions: We found a positive relation of increased levels of mean platelet volume and platelet distribution width with vestibular migraine. Higher mean platelet volume is associated with atherosclerosis and thromboembolism. Vascular pathologies are blamed for both headache syndromes like migraine and vertiginous syndromes. This theory supports our study but pathophysiological mechanism is not clear.

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“…PLR has also been used frequently as an indicator of inflammation in many studies. Ulusoy et al (15) studied PLR in tinnitus patients and they found no difference when compared to the control group. On the other hand, Atan et al (24) claimed that PLR can be used as diagnostic parameter for pediatric chronic serous otitis media.…”

Section: Discussionmentioning

confidence: 96%

“…The NLR has been examined in many otolaryngological conditions. Ulusoy et al (15) examined NLR in tinnitus and found no significant difference between tinnitus patients and control group. However, Ozbay et al (16) claimed that NLR could be used as a potential clinical marker in tinnitus patients.…”

Section: Discussionmentioning

confidence: 98%

Are Hematological Parameters Useful in Assessing Disease Activity in Chronic Otitis Media?

Altın¹,

Alimoğlu²

2020

Haseki

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Investigation of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio and mean platelet volume in patients with tinnitus

Abstract: The results suggest that a prothrombotic condition might play a role in the pathophysiology of tinnitus.

Cited by 16 publications

References 16 publications

Acupuncture Treatment in Patients with Chronic Subjective Tinnitus: A Prospective, Randomized Study

Acupuncture Treatment in Patients with Chronic Subjective Tinnitus: A Prospective, Randomized Study

Increased mean platelet volume in patients with vestibular migraine

Are Hematological Parameters Useful in Assessing Disease Activity in Chronic Otitis Media?

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