Investigation of neural progenitor cell induced angiogenesis after embolic stroke in rat using MRI

Jiang, Quan; Zhang, Zheng Gang; Ding, Guangliang; Zhang, Li; Ewing, James R.; Wang, Lei; Zhang, Ruilan; Li, Lian; Lü, Mei; Meng, He; Arbab, Ali S.; Hu, Jiani; Li, Qing Jiang; D, Siamak Pourabdollah Nejad; Athiraman, Hemanthkumar; Chopp, Michael

doi:10.1016/j.neuroimage.2005.06.063

Cited by 147 publications

(172 citation statements)

References 38 publications

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“…As early as 3 days after ischemic injury, new blood vessels are observed in the stroke-affected penumbra, and growth continues to increase for at least 21 days. 34 Transplanted cell-induced blood vessel formation has been reported with BMSCs, 56,96 NSCs, 43 and cells from human cord blood 79 or peripheral blood. 76 The ability of transplanted cells to increase endogenous levels of angiogenic factors (such as the aforementioned VEGF, fibroblast growth factor, and BDNF) and chemoattractant factors (for example, SDF-1) induces the proliferation of existing vascular endothelial cells (angiogenesis) and mobilization and homing of endogenous endothelial progenitors (vasculogenesis).…”

Section: Stem Cell-induced Angiogenesismentioning

confidence: 99%

Intravascular cell replacement therapy for stroke

Guzman

Choi²,

Gera³

et al. 2008

FOC

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✓ The use of stem cell transplantation to restore neurological function after stroke is being recognized as a potential novel therapy. Before stem cell transplantation can become widely applicable, however, questions remain about the optimal site of delivery and timing of transplantation. In particular, there seems to be increasing evidence that intravascular cell delivery after stroke is a viable alternative to intracerebral transplantation. In this review, the authors focus on the intravascular delivery of stem cells for stroke treatment with an emphasis on timing, transendothelial migration and possible mechanisms leading to neuroprotection, angiogenesis, immunomodulation, and neural plasticity. They also review current concepts of in vivo imaging and tracking of stem cells after stroke.

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Section: Stem Cell-induced Angiogenesismentioning

confidence: 99%

Intravascular cell replacement therapy for stroke

Guzman

Choi²,

Gera³

et al. 2008

FOC

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“…Several studies have explored the possibility of transplanting neural stem cells (NSCs) derived from the subventricular zone in animal stroke models and have reported successful differentiation of these cells into different neurons and glial cell types, with their robust migration to the ischemic area and resultant improvement in functional behavioral tests [146][147][148]. An enriched environment appears to improve NSCs migration and functional recovery [149].…”

Section: Neural Stem Cellsmentioning

confidence: 99%

Investigational Therapies for Ischemic Stroke: Neuroprotection and Neurorecovery

2011

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Stroke is one of the leading causes of death and disability worldwide. Current treatment strategies for ischemic stroke primarily focus on reducing the size of ischemic damage and rescuing dying cells early after occurrence. To date, intravenous recombinant tissue plasminogen activator is the only United States Food and Drug Administration approved therapy for acute ischemic stroke, but its use is limited by a narrow therapeutic window. The pathophysiology of stroke is complex and it involves excitotoxicity mechanisms, inflammatory pathways, oxidative damage, ionic imbalances, apoptosis, angiogenesis, neuroprotection, and neurorestoration. Regeneration of the brain after damage is still active days and even weeks after a stroke occurs, which might provide a second window for treatment. A huge number of neuroprotective agents have been designed to interrupt the ischemic cascade, but therapeutic trials of these agents have yet to show consistent benefit, despite successful preceding animal studies. Several agents of great promise are currently in the middle to late stages of the clinical trial setting and may emerge in routine practice in the near future. In this review, we highlight select pharmacologic and cell-based therapies that are currently in the clinical trial stage for stroke.

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“…Unfortunately, they do not provide objective and accurate quantifi cation of injury volumes. Some investigators have developed automated lesion segmentation methods that use manual thresholds [ 14 ] , crosscorrelations based on ad hoc templates [ 15 ] , Otsu's algorithm [ 16 ] on similarity maps of intensity and proximity [ 17 ] , or use manually derived percentage of maximum values from apparent diffusion coeffi cient (ADC) maps in neonates with stroke [ 6,18 ] . In most cases, these approaches are ad hoc and are not robust to MR signal and noise level variations across different datasets.…”

Section: Current Computational Approaches For Lesion Detectionmentioning

confidence: 99%

Computational Analysis: A Bridge to Translational Stroke Treatment

Ghosh

Sun

Turenius

et al. 2012

Translational Stroke Research

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Objective rapid quantifi cation of injury using computational methods can improve the assessment of the degree of stroke injury, aid in the selection of patients for early or specifi c treatments, and monitor the evolution of injury and recovery. In this chapter, we use neonatal ischemia as a case-study of the application of several computational methods that in fact are generic and applicable across the age and disease spectrum. We provide a summary of current computational approaches used for injury detection, including Gaussian mixture models (GMM), Markov random fi elds (MRFs), normalized graph cut, and K-means clustering. We also describe more recent automated approaches to segment the region(s) of ischemic injury including hierarchical region splitting, support vector machine, a brain symmetry/asymmetry integrated model, and a watershed method that are robust at different developmental stages. We conclude with our assessment of probable future research directions in the fi eld of computational noninvasive stroke analysis such as automated detection of the ischemic core and penumbra, monitoring of implanted neuronal stem cells in the ischemic brain, injury localization specifi c to different brain anatomical regions, and quantifi cation of stroke evolution, recovery and spatiotemporal interactions between injury volume/severity and treatment. Computational analysis is expected to open a new horizon in current clinical and translational stroke research by exploratory data mining that is not detectable using the standard "methods" of visual assessment of imaging data.

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Investigation of neural progenitor cell induced angiogenesis after embolic stroke in rat using MRI

Cited by 147 publications

References 38 publications

Intravascular cell replacement therapy for stroke

Intravascular cell replacement therapy for stroke

Investigational Therapies for Ischemic Stroke: Neuroprotection and Neurorecovery

Computational Analysis: A Bridge to Translational Stroke Treatment

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