Investigation of nephrotoxicity on mice exposed to polystyrene nanoplastics and the potential amelioration effects of DHA-enriched phosphatidylserine

Zhao, Rui; Pu, Qiuyan; Su, Jian; Yu, Fangmiao; Yang, Zuisu; Han, Tao

doi:10.1016/j.scitotenv.2023.164808

Cited by 29 publications

(14 citation statements)

References 56 publications

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“…As mentioned previously, acetaldehyde and oxidative stress generated during alcohol metabolism can be a cause of lipid metabolism disorders [ 4 ]. In particular, alcohol consumption can inhibit the phosphorylation of AMPK, a key regulator of lipid metabolism, and increase the expression of SREBPs [ 4 , 26 ]. In liver tissue, SREBPs are transcription factors that regulate genes related to the synthesis of cholesterol, fatty acids, and triglycerides [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

“…In particular, alcohol consumption can inhibit the phosphorylation of AMPK, a key regulator of lipid metabolism, and increase the expression of SREBPs [ 4 , 26 ]. In liver tissue, SREBPs are transcription factors that regulate genes related to the synthesis of cholesterol, fatty acids, and triglycerides [ 26 ]. Among them, SREBP-1 has been reported to increase in a dose-dependent manner by acetaldehyde treatment at the cellular level and regulates the transcription of genes involved in triglyceride synthesis such as FAS and stearoyl-CoA desaturase [ 4 , 26 ].…”

Section: Discussionmentioning

confidence: 99%

“…In liver tissue, SREBPs are transcription factors that regulate genes related to the synthesis of cholesterol, fatty acids, and triglycerides [ 26 ]. Among them, SREBP-1 has been reported to increase in a dose-dependent manner by acetaldehyde treatment at the cellular level and regulates the transcription of genes involved in triglyceride synthesis such as FAS and stearoyl-CoA desaturase [ 4 , 26 ]. According to a recent study, PPAR-γ, which is involved in the storage of fatty acid and regulation of glucose metabolism, is reported to be a factor that can enhance the lipogenic action of SREBP-1c [ 5 , 27 ].…”

Section: Discussionmentioning

confidence: 99%

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Hepatoprotective Effect of Allium ochotense Extracts on Chronic Alcohol-Induced Fatty Liver and Hepatic Inflammation in C57BL/6 Mice

Go,

Kim,

Lee

et al. 2024

IJMS

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This study was performed to investigate the protective effects of Allium ochotense on fatty liver and hepatitis in chronic alcohol-induced hepatotoxicity. The physiological compounds of a mixture of aqueous and 60% ethanol (2:8, w/w) extracts of A. ochotense (EA) were identified as kestose, raffinose, kaempferol and quercetin glucoside, and kaempferol di-glucoside by UPLC Q-TOF MSE. The EA regulated the levels of lipid metabolism-related biomarkers such as total cholesterol, triglyceride, low-density lipoprotein (LDL), and high-density lipoprotein (HDL)-cholesterol in serum. Also, EA ameliorated the levels of liver toxicity-related biomarkers such as glutamic oxaloacetic transaminase (GOT), glutamic pyruvic transaminase (GPT), and total bilirubin in serum. EA improved the antioxidant system by reducing malondialdehyde contents and increasing superoxide dismutase (SOD) levels and reduced glutathione content. EA improved the alcohol metabolizing enzymes such as alcohol dehydrogenase, acetaldehyde dehydrogenase, and cytochrome P450 2E1 (CYP2E1). Treatment with EA alleviated lipid accumulation-related protein expression by improving phosphorylation of AMP-activated protein kinase (p-AMPK) expression levels. Especially, EA reduced inflammatory response by regulating the toll-like receptor–4/nuclear factor kappa-light-chain-enhancer of activated B cells (TLR-4/NF-κB) signaling pathway. EA showed an anti-apoptotic effect by regulating the expression levels of B-cell lymphoma 2 (BCl-2), BCl-2-associated X protein (BAX), and caspase 3. Treatment with EA also ameliorated liver fibrosis via inhibition of transforming growth factor-beta 1/suppressor of mothers against decapentaplegic (TGF-β1/Smad) pathway and alpha-smooth muscle actin (α-SMA). Therefore, these results suggest that EA might be a potential prophylactic agent for the treatment of alcoholic liver disease.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Hepatoprotective Effect of Allium ochotense Extracts on Chronic Alcohol-Induced Fatty Liver and Hepatic Inflammation in C57BL/6 Mice

Go,

Kim,

Lee

et al. 2024

IJMS

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show abstract

“…Inflammation is the body's response to destructive stimuli, microbial pathogens, and inflammatory factors for pathological activities caused by stimulation, thereby harming the organs or tissues of the body [ 72 ]. Additionally, inflammatory reactions exacerbate disease progression and affect treatment, prognosis, and outcomes [ [73] , [74] , [75] ]. E. ulmoides bark, leaves, staminate flowers, and seeds contain numerous bioactive compounds with various pharmacological activities.…”

Section: Anti-inflammatory Activity Of E Ulmoidesmentioning

confidence: 99%

Biological properties and potential application of extracts and compounds from different medicinal parts (bark, leaf, staminate flower, and seed) of Eucommia ulmoides: A review

Peng,

Zhou,

Liu

2024

Heliyon

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“…Fish by-products like roes, gonads, skin, and heads are also known to contain important amounts of n-3 PUFA, particularly DHA [ 28 ]. As these fractions are usually discarded by the fish industry or used in low-value products (as feed, for example), they represent a significant amount of undervalued natural resources that could and should be upgraded through the formulation of added-value products, such as food supplements or ingredients for food fortification [ 29 , 30 , 31 ].…”

Section: Introductionmentioning

confidence: 99%

New Forms of Neuroactive Phospholipids for DHA Enrichment in Brain

Gomes,

Mendes,

Duarte

et al. 2024

Marine Drugs

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Low levels of docosahexaenoic acid (DHA) in the brain have been related to neurological disorders, like Alzheimer’s disease (AD). After ingestion, dietary DHA must cross the blood–brain barrier, where it is absorbed as lysophosphatidylcholine (LPC), due to its role as a preferential DHA carrier in the brain. This work aimed at the production of LPC-DHA extracts to be used in supplementation/food fortification intended neural enrichment in DHA. As it is rich in DHA, especially its phospholipids (PL), Atlantic mackerel (Scomber scombrus, caught in Spring/2022) was used as a raw material. The polar lipids fraction was separated and hydrolysed with Rhizomucor miehei lipase, to enzymatically convert phosphatidylcholine (PC) into LPC. The fish (muscle and by-products) lipids fraction was used for total lipids (TL) content, lipid classes (LC) and fatty acid (FA) profile evaluation, whilst polar lipids extracts were studied for LC production and FA analysis. Muscle TL ranged between 1.45 and 4.64 g/100 g (WW), while by-products accounted for 7.56-8.96 g/100 g, with the highest contents being found in March. However, PL were more abundant in muscle (22.46–32.20% of TL). For polar lipids extracts, PL represented 50.79% of TL, among which PC corresponded to 57.76% and phosphatidylethanolamine to 42.24%. After hydrolysis, nearly half of this PC was converted into LPC. When compared to the initial PC, DHA relative content (33.6% of total FA) was significantly higher after hydrolysis: 55.6% in PC and 73.6% in LPC. Such extract, obtained from this undervalued species, may represent a promising strategy to increase DHA uptake into brain cells while allowing this species to upgrade.

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Investigation of nephrotoxicity on mice exposed to polystyrene nanoplastics and the potential amelioration effects of DHA-enriched phosphatidylserine

Cited by 29 publications

References 56 publications

Hepatoprotective Effect of Allium ochotense Extracts on Chronic Alcohol-Induced Fatty Liver and Hepatic Inflammation in C57BL/6 Mice

Hepatoprotective Effect of Allium ochotense Extracts on Chronic Alcohol-Induced Fatty Liver and Hepatic Inflammation in C57BL/6 Mice

Biological properties and potential application of extracts and compounds from different medicinal parts (bark, leaf, staminate flower, and seed) of Eucommia ulmoides: A review

New Forms of Neuroactive Phospholipids for DHA Enrichment in Brain

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