Investigation of multi-site micro recordings of subthalamic nucleus neurons using machine learning MER with DBS in Parkinson`s – A simulation study

Abstract

Multineural spikes were acquired with a multisite electrode placed in the hippocampus pyramidal cell layer of non-primate anesthetized snitch animals. If the impedance of each electrode-site is relatively low and the distance amongst electrode sites is appropriately miniatured, a spike generated by a neuron is parallelly recorded at multielectrode sites with different amplitudes. The covariance between the spike of the at each electrode-point and a template was computed as a damping-factor due to the volume conduction of the spike from the neuron to electrode-site. Computed damping factors were vectorized and analyzed by simple but elegant hierarchical-clustering using a multidimensional statistical-test. Since a cluster of damping vectors was shown to correspond to an antidromically identified neuron, spikes of distinct neurons are classified by suggesting to the scatterings of damping vectors. Errors in damping vector computing due to partially overlapping spikes were minimized by successively subtracting preceding spikes from raw data. Clustering errors due to complex-spike-bursts (i.e., spikes with variable-amplitudes) were prevented by detecting such bursts and using only the first spike of a burst for clustering.

Abstracts

“…[3] The uniqueness of diabetic striatopathy is that it is usually self-limiting with prompt management of the hyperglycemia. It occurs in non ketotic hyperglycemic hyperosmolar state (HHS) [4,5], uncommon with Diabetic Ketoacidosis (DKA) and rare without DKA [6] Hyperintense signal in contralateral (to the side of the abnormal movements) putamen on T1-WI without surrounding edema or mass effect, along with hyperglycemia and choreiform movements, is pathognomonic of DS [7,8]. The patient was started on Tetrabenazine 25mg BD for 15 days,however she did not reposnd to the same and was then started on Haloperidol 0.5mg HS with an advise to follow up after 1 month.…”

“…Background: Hyperreflexia is often seen in PD 1 and muscle strength is diminished 2 . Various studies have suggested the relationship between the muscles and cognitive functions [3][4][5][6][7] . How it affects cognitive performance is not well understood.…”

“…Data were corrected for susceptibility distortions [2] and eddy current distortions [3]. Changes in the commonly used DTI metrics i.e., fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) were studied using an automated analysis technique i.e., whole brain tract based spatial statistics (TBSS) [4,5]. Statistical inference was obtained using a non-parametric method called Threshold-Free Cluster Enhancement (TFCE) with 1287 permutations [6].…”

“…2)Explore various contributory factors for sexual dysfunction in YOPD Background: Non-motor symptoms in Parkinson's disease (PD)may precede motor symptoms and contribute significantly to overall morbidity[1,2].Among them,sexual dysfunction is prominent and frequently overlooked especially in YOPD[3].Severity varies with stage of the disease and various psychological factors [4,5].…”

Subthalamic nucleus projection by SVM based MER Data via deep brain stimulation: A study of spike uncovering

“…The STN-DBS was developed as a basic corrective option, is an active therapy for patients with Parkinson's disease (PD) 1 when PD motor symptoms such as tremor, rigidity, and Bradykinesia, and postural instability are not preventive by the medication. 2 However, its success is impeded by limited and some degree of knowledge of restorative mechanisms and the lack of a robust feedback signal for tailoring induced stimulations. The fundamental outcomes of the induced stimuli are for the progress of these key objective motor symptoms.…”