Investigation of molluscum contagiosum virus, orf and other parapoxviruses in lymphomatoid papulosis

Fernandez, Kristen; Bream, Matthew J.; Ali, Mir A.; Krogmann, Tammy; Liu, Yu; Cohen, Jeffrey I.; Damon, Inger K.; Liu, Vincent

doi:10.1016/j.jaad.2012.12.972

Cited by 8 publications

(10 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The Orf virus (ORFV) is a prototype member of the Parapoxvirus genus within the Poxviridae family and the viral genome consists of a linear double-stranded DNA (137–139 kbp in length). ORFV is the causative agent of contagious ecthyma or contagious papular dermatitis (Orf) in goats, sheep and other ruminants, with a worldwide distribution and significant financial importance [ 1 , 2 ]. The clinical symptoms of Orf manifest as the formation of papules, vesicles and growing scabs on the lips and muzzle of infected animals [ 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

Development of a fluorescent probe-based recombinase polymerase amplification assay for rapid detection of Orf virus

Yang

Qin

Wang

et al. 2015

Virol J

View full text Add to dashboard Cite

BackgroundOrf virus (ORFV) is the causative agent of Orf (also known as contagious ecthyma or contagious papular dermatitis), a severe infectious skin disease in goats, sheep and other ruminants. The rapid detection of ORFV is of great importance in disease control and highly needed. A isothermal molecular diagnostic approach, termed recombinase polymerase amplification (RPA), is considered as an novel and rapid alternative techonology to PCR assay.ResultsIn the present study, a novel fluorescent probe based on RPA assay (ORFV exo RPA assay) was developed. The developed ORFV exo RPA assay was capable of as low as 100 copies of ORFV DNA /reaction and was highly specific, with no cross-reaction with closely related viruses (capripox virus, foot-and-mouth disease virus or peste des petits ruminants virus). Further assessment with clinical samples showed that the developed ORFV exo RPA assay has good correlation with qPCR assays for detection of ORFV.ConclusionsThese results suggest that the developed ORFV exo RPA assay is suitable for rapid detection of ORFV.Electronic supplementary materialThe online version of this article (doi:10.1186/s12985-015-0440-z) contains supplementary material, which is available to authorized users.

show abstract

Section: Introductionmentioning

confidence: 99%

Development of a fluorescent probe-based recombinase polymerase amplification assay for rapid detection of Orf virus

Yang

Qin

Wang

et al. 2015

Virol J

View full text Add to dashboard Cite

show abstract

“…

usually not as abundant as in the case of granulomatous responses to pigmented cysts. [7][8][9][10][11][12][13] The two previous similar studies we found 5,6 do not report their patients' phototype, but being from India suggests that both are likely a dark skin type. Our patient also had a high phototype IV.Although it is interesting that the phenomenon of pigmented granulomas against keratin is not as common in the literature, there are examples of histiocytic reactions with lower cytoplasmic amounts of melanin (melanophages) that are very common in inflammatory processes involving destruction of the basal layer of the epidermis.Furthermore, there is a phenomenon in oral pathology where pigmented granulomas are not as infrequent: pigmented periradicular cysts resulting from tooth extraction.

…”

mentioning

confidence: 95%

“…usually not as abundant as in the case of granulomatous responses to pigmented cysts. [7][8][9][10][11][12][13] The two previous similar studies we found 5,6 do not report their patients' phototype, but being from India suggests that both are likely a dark skin type. Our patient also had a high phototype IV.…”

mentioning

confidence: 95%

“…2 Regardless of the variable immunoprofile, most evidence supports the notion that the lymphoid infiltrate represents an amplified CD30-positive activated lymphoblastdriven pseudolymphomatous inflammatory immune response to exposed viral antigens. [1][2][3]6,7 In our series, 2 skin samples from 2 topographically different lesions and step sectioning helped reach the correct diagnosis. Deeper levels of the biopsy from the trunk of the third patient were not performed and were misdiagnosed as lymphomatoid papulosis.…”

mentioning

confidence: 99%

“…An atypical CD30-positive lymphomatoid reaction occurs secondary to a variety of viral infections, pityriasis lichenoides et varioliformis acuta, drugs and insect bite. 1,2,4,6,7 Clinical correlation and recognition of the primary viral cytopathic lesion is reassuring.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Molluscum Contagiosum–Associated Atypical CD30-Positive Lymphomatoid Papulosis-like Infiltrate: Report of Three Cases

AbdullGaffar,

Abdulrhaman

2023

The American Journal of Dermatopathology

View full text Add to dashboard Cite

Exploring cutaneous lymphoproliferative disorders in the wake of COVID‐19 vaccination

Gordon,

Adeuyan,

Kwinta

et al. 2024

Skin Health and Disease

View full text Add to dashboard Cite

BackgroundIndividual reports have described lymphoproliferative disorders (LPDs) and cutaneous lymphomas emerging after administration of the COVID‐19 vaccine; however, the relationship between reactions and vaccine types has not yet been examined.ObjectiveDetermine if there are cases of cutaneous LPDs associated with certain COVID‐19 vaccines and their outcomes.MethodsWe analysed PubMed, the Vaccine Adverse Events Reporting System (VAERS), and our database for instances of biopsy‐proven LPDs following COVID‐19 vaccines.ResultsFifty cases of biopsy‐proven LPDs arising after COVID‐19 vaccination were found: 37 from medical literature, 11 from VAERS and two from our institution. Geographical distribution revealed the most cases in the United States, Italy, and Greece, with single cases in Spain, Colombia, Canada, Japan, and Romania. The average age of patients was 53; with a slight male predominance (male‐to‐female ratio of 1.5:1). The Pfizer‐BioNTech vaccine was associated with LPDs in 36/50 (72%) cases, aligning with its 70% share of the global vaccine market. Histopathology revealed CD30+ in 80% of cases. The most prevalent form of LPD was lymphomatoid papulosis (LyP, 30%). All reported cases produced favourable outcomes (either complete or near‐complete remission). Therapeutic approaches ranged from observation to treatment with steroids, methotrexate, or excision.ConclusionLPDs after COVID‐19 vaccination appear in the context of the same vaccines (proportionally to their global market shares), share clinical and pathological findings, and have indolent, self‐limited character.

show abstract

Investigation of molluscum contagiosum virus, orf and other parapoxviruses in lymphomatoid papulosis

Cited by 8 publications

References 5 publications

Development of a fluorescent probe-based recombinase polymerase amplification assay for rapid detection of Orf virus

Development of a fluorescent probe-based recombinase polymerase amplification assay for rapid detection of Orf virus

Molluscum Contagiosum–Associated Atypical CD30-Positive Lymphomatoid Papulosis-like Infiltrate: Report of Three Cases

Exploring cutaneous lymphoproliferative disorders in the wake of COVID‐19 vaccination

Contact Info

Product

Resources

About