Investigation of Metal(II)-Curcumin-Glycine Complexes : Preparation, Structural Characterization and Biological Activities

Abstract

A novel Schiff base obtained from curcumin and glycine was prepared and it was reacted with Co, Ni, Cu and Zn metals in order to form the stable metal complexes and characterized by elemental analysis, magnetic, molar conductance, IR, UV-Vis.,1H NMR and PXRD. The data shows that the complexes have the structure [M(II)-(cur-gly)H2O] system Electronic and magnetic data suggest a tetrahedral geometry for Co, Ni and Zn except Cu complex has a square planar geometry. The antimicrobial activity of cur-gly and its metal chelates were confirmed against the bacterial species as E. coli, P. aeruginosa, Enterococcus, B. cereus and S. aureus species. Antifungal activity was screened against C. albicans, C. parapsilosis and A. flavus. Metal chelates indicate excellent antimicrobial activity than their parent cur-gly and DNA photo cleavage activity shows that metal chelate effectively cleave the pUC 18 DNA.