Investigation of mesalazine as an antifibrotic drug following myocardial infarction in male mice
Stephan R. Künzel,
Luise Winter,
Maximilian Hoffmann
et al.
Abstract:ObjectivesMyocardial infarction (MI) initiates a complex reparative response during which damaged cardiac muscle is replaced by connective tissue. While the initial repair is essential for survival, excessive fibrosis post‐MI is a primary contributor to progressive cardiac dysfunction, and ultimately heart failure. Currently, there are no approved drugs for the prevention or the reversal of cardiac fibrosis. Therefore, we tested the therapeutic potential of repurposed mesalazine as a post‐MI therapy, as distin… Show more
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