Investigation of mathematical models based on diffusion control release for Paclitaxel from <i>in-situ</i> forming PLGA microspheres containing HSA microparticles

Amini‐Fazl, Mohammad Sadegh; Mobedi, Hamid

doi:10.1080/10667857.2019.1651549

Cited by 18 publications

(13 citation statements)

References 50 publications

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“…The Korsmeyer-Peppas model has the highest R 2 which suggests that this model can fit into the release mechanism of allopurinol from CCA biocomposites into the pH 2.0 and pH 7.4 solutions for almost all investigated samples. These results complied with the release process of some drugs released from polymers [52,53] because the release of allopurinol from CCA biocomposite films is a complex process which includes swelling, disintegration, protonation, diffusion, dissolution, and erosion. The values of the diffusion constant (n) obtained from the KP model range from 0.361 to 0.619 depending on the component ratio of the samples and the pH of the solutions.…”

Section: Drug Release Process Of Allopurinol Fromsupporting

confidence: 69%

“…The kinetics of the allopurinol release process from CCA biocomposite films was fitted according to the zero order kinetic (ZO) model, the Higuchi (HG) model, the Hixson-Crowell (HC) model, the Peppas-Sahlin (PS) model, and the Korsmeyer-Peppas (KP) model based on the data of the amount of drug released [10,36,[52][53][54][55]. The R-square method (R 2 ) and loss functions including the sum of squared error (SSE), mean squared error (MSE), and p were applied to determine the most suitable kinetic model which can represent the allopurinol release process from CCA biocomposite films.…”

Section: Drug Release Process Of Allopurinol Frommentioning

confidence: 99%

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A Novel Method for Preparation of Carrageenan/Fish Scale Collagen/Allopurinol Biocomposite Film

Nguyen

Dam

et al. 2021

International Journal of Polymer Science

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Biopolymers such as carrageenan or collagen can be used as carriers for loading a drug to enhance a drug’s bioavailability. In this work, allopurinol was loaded on a carrageenan/collagen blend and the carrageenan/collagen/allopurinol (CCA) biocomposite films were prepared using the ionic gelation method combined with the 3D printing method using carrageenan/collagen/allopurinol gel as a 3D printing ink material. The advantages of the 3D printing method are the ease in shaping the design of films and the ease in controlling the thickness of films. The results of infrared (IR) spectroscopy and field emission scanning electron microscopy (FESEM) analyses showed that the CCA biocomposite films have a regular structure, and the functional groups of components in the biocomposites can interact with each other. After 30 minutes of immersion in distilled water and pH buffer solution, the biocomposite films swelled and disintegrated. The carrageenan/collagen blend can control the release of allopurinol in simulated body fluids. In addition, the drug release kinetic models reflecting the release process of allopurinol from CCA biocomposite films in simulated body fluids have also been calculated.

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Section: Drug Release Process Of Allopurinol Fromsupporting

confidence: 69%

Section: Drug Release Process Of Allopurinol Frommentioning

confidence: 99%

A Novel Method for Preparation of Carrageenan/Fish Scale Collagen/Allopurinol Biocomposite Film

Nguyen

Dam

et al. 2021

International Journal of Polymer Science

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“…This model showed to be in agreement with experimental results. Amini-Fazl and Mobedi ( 2020 ) proposed a theoretical model based on diffusion-control release together with semi-empirical models, capable of calculating the release rate constants, release exponent and average drug diffusion coefficients and to evaluate their variations with PLGA MW. In detail, the authors included Ritger–Peppas, Weibull and Peppas–Sahlin formulas and a theoretical one obtained from Fick’s second law.…”

Section: Drug Encapsulation and In Vitro And In Vivo Releasementioning

confidence: 99%

Recent advances in the formulation of PLGA microparticles for controlled drug delivery

et al. 2020

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Polymeric microparticles (MPs) are recognized as very popular carriers to increase the bioavailability and bio-distribution of both lipophilic and hydrophilic drugs. Among different kinds of polymers, poly-(lactic-co-glycolic acid) (PLGA) is one of the most accepted materials for this purpose, because of its biodegradability (due to the presence of ester linkages that are degraded by hydrolysis in aqueous environments) and safety (PLGA is a Food and Drug Administration (FDA)-approved compound). Moreover, its biodegradability depends on the number of glycolide units present in the structure, indeed, lower glycol content results in an increased degradation time and conversely a higher monomer unit number results in a decreased time. Due to this feature, it is possible to design and fabricate MPs with a programmable and time-controlled drug release. Many approaches and procedures can be used to prepare MPs. The chosen fabrication methodology influences size, stability, entrapment efficiency, and MPs release kinetics. For example, lipophilic drugs as chemotherapeutic agents (doxorubicin), anti-inflammatory non-steroidal (indomethacin), and nutraceuticals (curcumin) were successfully encapsulated in MPs prepared by single emulsion technique, while water-soluble compounds, such as aptamer, peptides and proteins, involved the use of double emulsion systems to provide a hydrophilic compartment and prevent molecular degradation. The purpose of this review is to provide an overview about the preparation and characterization of drug-loaded PLGA MPs obtained by single, double emulsion and microfluidic techniques, and their current applications in the pharmaceutical industry. Graphic abstract

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“…Another approach was focused on drug release mainly controlled by diffusion within a time-evolving matrix, and described a molecular weight/time-dependent drug diffusivity within the degrading particle [ 37 ]. Furthermore, diffusion-control release has been taken into account to fit release data with semi-empirical models, such as Ritger-Peppas, Weibull, and Peppas-Sahlin, and a theoretical approach relying on Fick’s second law, aiming to correlate release kinetic parameters with PLGA molecular weight and MS formulation [ 38 ].…”

Section: Introductionmentioning

confidence: 99%

Experimental Studies and Modeling of the Degradation Process of Poly(Lactic-co-Glycolic Acid) Microspheres for Sustained Protein Release

Netti

Frigione

2020

Polymers

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In this study, poly(lactic-co-glycolic acid) microspheres (PLGA MS)for controlled protein release by double emulsion-solvent evaporation were produced and characterized for their morphological and technological features. MS autocatalytic degradation was described by a mathematical model based on a Michaelis and Menten-like chemical balance. Here, for the first time MS degradation was correlated to the advancement of MS degradation front with respect to the degraded radius, derived from mass loss experiments. The model can satisfactorily describe the kinetics of advancement of the degradation front experimentally derived for all MS formulations, especially when produced at higher PLGA concentrations.

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Investigation of mathematical models based on diffusion control release for Paclitaxel from in-situ forming PLGA microspheres containing HSA microparticles

Cited by 18 publications

References 50 publications

A Novel Method for Preparation of Carrageenan/Fish Scale Collagen/Allopurinol Biocomposite Film

A Novel Method for Preparation of Carrageenan/Fish Scale Collagen/Allopurinol Biocomposite Film

Recent advances in the formulation of PLGA microparticles for controlled drug delivery

Experimental Studies and Modeling of the Degradation Process of Poly(Lactic-co-Glycolic Acid) Microspheres for Sustained Protein Release

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