Investigation of lipids profile with special reference to vitamin C in vivax malaria patients in region of Sargodha

Abstract

Pakistan stands among 10 countries presumed to be largest population susceptible for the vivax malaria. Vivax malaria is most often benign tertian malaria. It is often mistakenly speculated to be benign however it is actually severe and acute. Body needs vitamin C for normal physiological processes. Due to the fact vitamin C act as a strong antioxidant agent its deficiency may cause weak the body immunity. By using standard procedures and kits, the parameters estimated were as follows: vitamin C, Lipid profile (Total cholesterol, Very low-density lipoprotein (VLDL) , Low-density lipoprotein (LDL) cholesterol, High-density lipoprotein (HDL) and Total triglycerides, were evaluated by using automated analyzer, Micro Lab 300. At the end of the study it was concluded that by comparison of normal (n=43) and malarious (n=65) subjects of two age groups (≤15) and (>15) year, there were significant (p<0.05) differences observed. A significant decrease was found in vitamin C, HDL Cholesterol and LDL Cholesterol in vivax malaria patients. It was also positively correlates with severity of disease. No significant difference was observed in total cholesterol, total triglycerides and VLDL Cholesterol. The conclusion of this study was that alteration in these parameters suggests proper monitoring during treatment in order to reverse them to normal levels.

Letrozole Attenuates Cardiometabolic Risk in Plasmodium Berghei-Infected Mice

“…Alteration in lipid profile is a characteristic feature of malaria 33 . Although the plausible mechanism for this alteration is not clear, it may depend on Plasmodium sp., host, or host-parasite interaction 34 .…”