Investigation of lateral geniculate nucleus volume and diffusion tensor imaging in patients with normal tension glaucoma using 7 tesla magnetic resonance imaging

Schmidt, Manuel; Knott, Michael; Heidemann, Robin M.; Michelson, Georg; Kober, Tobias; Dörfler, Arnd; Engelhorn, Tobias

doi:10.1371/journal.pone.0198830

Cited by 30 publications

(35 citation statements)

References 28 publications

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“…The number of NeuN-positive cells was decreased in all the layers (A, A1, and C) projected from the OH eyes (Tables 1 and 2). Previously, decreased the number of neurons in the LGN in monkeys [7,44,45] and decreased LGN volume in humans [46] has been reported. Our findings in ferrets corroborate these results.…”

Section: Discussionmentioning

confidence: 98%

Structural Changes and Astrocyte Response of the Lateral Geniculate Nucleus in a Ferret Model of Ocular Hypertension

Fujishiro

Honjo

Kawasaki

et al. 2020

IJMS

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We investigated structural changes and astrocyte responses of the lateral geniculate nucleus (LGN) in a ferret model of ocular hypertension (OH). In 10 ferrets, OH was induced via the injection of cultured conjunctival cells into the anterior chamber of the right eye; six normal ferrets were used as controls. Anterograde axonal tracing with cholera toxin B revealed that atrophic damage was evident in the LGN layers receiving projections from OH eyes. Immunohistochemical analysis with antibodies against NeuN, glial fibrillary acidic protein (GFAP), and Iba-1 was performed to specifically label neurons, astrocytes, and microglia in the LGN. Significantly decreased NeuN immunoreactivity and increased GFAP and Iba-1 immunoreactivities were observed in the LGN layers receiving projections from OH eyes. Interestingly, the changes in the immunoreactivities were significantly different among the LGN layers. The C layers showed more severe damage than the A and A1 layers. Secondary degenerative changes in the LGN were also observed, including neuronal damage and astrocyte reactions in each LGN layer. These results suggest that our ferret model of OH is valuable for investigating damages during the retina–brain transmission of the visual pathway in glaucoma. The vulnerability of the C layers was revealed for the first time.

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Section: Discussionmentioning

confidence: 98%

Structural Changes and Astrocyte Response of the Lateral Geniculate Nucleus in a Ferret Model of Ocular Hypertension

Fujishiro

Honjo

Kawasaki

et al. 2020

IJMS

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“…Beim Glaukom ist das Volumen des CGL signifikant geringer als bei sehgesunden Kontrollprobanden (rechts: 60,4 vs. 87,7 mm 3 , p < 0,05; links: 61,8 vs. 88,8 mm 3 , p < 0,05; gemittelt: 60,9 vs. 88,3 mm 3 , p = 0,05). Es gibt eine starke positive Korrelation des Volumens des CGL mit der jeweiligen Gegenseite (r = 0,768, p = 0,001) [7] (▶ Abb. 2 und 3 A).…”

Section: Dreidimensionale Volumetrie Und Diffusionsgewichtete Ultrahounclassified

“…Die FA in der Sehstrahlung (4. Neuron) ist ebenfalls signifikant reduziert (rechts 0,41 vs. 0,70, p < 0,05; links 0,41 vs. 0,69, p < 0,05; gemittelt 0,41 vs. 0,69) [7] (▶ Abb. 3 B und C).…”

Section: Dreidimensionale Volumetrie Und Diffusionsgewichtete Ultrahounclassified

“…Eine Korrelationsanalyse des CGL-Volumens mit der Nervenfaserdicke (RNFL) zeigte eine hohe, signifikante Korrelation des nasalen Sektors der Retina mit dem Volumen des kontralateralen CGL (r = 0,471, p = 0,05) und des temporalen Sektors der Retina mit dem Volumen des ipsilateralen CGL (superior temporaler und temporaler Sektor: r = 0,509, p = 0,038 und r = 0,603, p = 0,015) [7] (▶ Abb. 6).…”

Section: Dreidimensionale Volumetrie Und Diffusionsgewichtete Ultrahounclassified

“…des Corpus geniculatum laterale (CGL), der "Verschaltungsstation" vom 3. auf das 4. Neuron, exakt zu erfassen und zu quantifizieren [7].…”

Section: Introductionunclassified

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Beeinträchtigung der Sehbahn bei Glaukomen

Schmidt

Engelhorn

Dörfler

et al. 2019

Klin Monatsbl Augenheilkd

Self Cite

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ZusammenfassungBei Glaukomen ist die Darstellung der Sehbahn mittels Diffusionsbildgebung und metabolischer MRT möglich; es findet sich mit zunehmendem Alter eine Atrophie der Sehstrahlung, welche das Ausmaß der physiologischen Hirnvolumenminderung deutlich übersteigt. Bei den unterschiedlichen Glaukomsubtypen erlaubt die qualitative Auswertung der Diffusionsbildgebung mit Berechnung von fraktionaler Anisotropie (FA) und radialer Diffusivität (RD) die Beurteilung der axonalen Integrität entlang der Sehbahn. Es finden sich bei Glaukomen bereits im Anfangsstadium der Erkrankung deutliche FA- und RD-Veränderungen sowohl entlang der Sehbahn wie auch in weiteren Hirnregionen außerhalb der Sehbahn, die nahelegen, dass es sich beim Glaukom um eine komplexe neurodegenerative Erkrankung handelt. Die metabolische MRT wird uns künftig weitere Einblicke in die Pathophysiologie verschiedener Glaukomformen geben und damit zum Therapiemonitoring beitragen und die Diagnostik verbessern.

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Comparison of multiple tractography methods for reconstruction of the retinogeniculate visual pathway using diffusion MRI

Zhang

Xie

et al. 2021

Human Brain Mapping

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The retinogeniculate visual pathway (RGVP) conveys visual information from the retina to the lateral geniculate nucleus. The RGVP has four subdivisions, including two decussating and two nondecussating pathways that cannot be identified on conventional structural magnetic resonance imaging (MRI). Diffusion MRI tractography has the potential to trace these subdivisions and is increasingly used to study the RGVP. However, it is not yet known which fiber tracking strategy is most suitable for RGVP reconstruction. In this study, four tractography methods are compared, including constrained spherical deconvolution (CSD) based probabilistic (iFOD1) and deterministic (SD-Stream) methods, and multi-fiber (UKF-2T) and single-fiber (UKF-1T) unscented Kalman filter (UKF) methods. Experiments use diffusion MRI data from 57 subjects in the Human Connectome Project. The RGVP is identified using regions of interest created by two clinical experts. Quantitative anatomical measurements and expert anatomical judgment are used to assess the advantages and limitations of the four tractography methods. Overall, we conclude that UKF-2T and iFOD1 produce the best RGVP reconstruction results. The iFOD1 method can better quantitatively estimate the percentage of decussating fibers, while the UKF-2T method produces reconstructed RGVPs that are judged to better correspond to the known anatomy and have the highest spatial overlap across subjects.Overall, we find that it is challenging for current tractography methods to both accurately Jianzhong He and Fan Zhang are co-first-authors.

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Investigation of lateral geniculate nucleus volume and diffusion tensor imaging in patients with normal tension glaucoma using 7 tesla magnetic resonance imaging

Cited by 30 publications

References 28 publications

Structural Changes and Astrocyte Response of the Lateral Geniculate Nucleus in a Ferret Model of Ocular Hypertension

Structural Changes and Astrocyte Response of the Lateral Geniculate Nucleus in a Ferret Model of Ocular Hypertension

Beeinträchtigung der Sehbahn bei Glaukomen

Comparison of multiple tractography methods for reconstruction of the retinogeniculate visual pathway using diffusion MRI

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