Investigation of isotope dilution mass spectrometric (ID-MS) method to determine niacin in infant formula, breakfast cereals and multivitamins

Shin, Hyunju; Kim, Byung-Joo; Lee, Joon‐Hee

doi:10.1016/j.foodchem.2012.11.046

Cited by 20 publications

(10 citation statements)

References 15 publications

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“…KRISS assigned the certified values to these first food and supplement materials based on measurements using ID LC-MS methods developed specifically for the determination of each vitamin individually. Shin et al [72] developed an ID LC-MS method for niacin, validated the method using SRM 1849, and applied the method for the certification of infant formula CRM 108-02-001. In this same investigation, they confirmed the niacin value in BCR-431 (43 mg/kg ± 3 mg/kg) by their ID LC-MS method as 41.2 mg/kg ± 2.1 mg/kg.…”

Section: Recent Food- and Dietary Supplement-matrix Crms From Other Nmismentioning

confidence: 99%

Evolution of reference materials for the determination of organic nutrients in food and dietary supplements—a critical review

Wise

Phillips

2018

Anal Bioanal Chem

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For over 40 years, food-matrix certified reference materials (CRMs) have been available for determination of trace element content, and a wide variety of materials are available from most producers of CRMs. However, the availability of food-matrix CRMs for organic nutrients has been more limited. The European Commission (EC) Bureau Communautaire de Référence (BCR) and the National Institute of Standards and Technology (NIST) introduced food-matrix CRMs with values assigned for vitamins and other organic nutrients such as fatty acids and carotenoids in the 1990s. The number of organic nutrients for which values were assigned has increased significantly in the past decade, and the approach and analytical methods used for assignment of the certified values have also evolved. Recently, dietary supplement-matrix CRMs such as multivitamin tablets with values assigned for vitamins and carotenoids, and fish and plant oils with values assigned for fatty acids have appeared. The development, evolution, and improvement of food- and dietary supplement-matrix CRMs for determination of vitamins, carotenoids, and fatty acids are described, with emphasis on CRMs made available in the past 10 years. Recent food and dietary supplement CRMs for the determination of organic nutrients include infant formula, multivitamin tablets, milk and egg powders, breakfast cereal, meat homogenate, blueberries, soy flour, fish and plant oils, dry cat food, and protein drink powder. Many of these food- and supplement-matrix CRMs have values assigned for over 80 organic and inorganic nutrients, toxic elements, proximates, and contaminants. The review provides a critical assessment of the challenges and evolving improvements in the production and the analytical methods used for value assignment of these CRMs. The current status and future needs for additional food- and dietary supplement-matrix CRMs for organic nutrients are also discussed.

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Section: Recent Food- and Dietary Supplement-matrix Crms From Other Nmismentioning

confidence: 99%

Evolution of reference materials for the determination of organic nutrients in food and dietary supplements—a critical review

Wise

Phillips

2018

Anal Bioanal Chem

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“…11,12 The standard solution was stored at −20 o C freezer and used within a week. In a similar way, an internal standard solution containing the three isotope-labeled compounds (1000 mg/kg level in n-hexane) was prepared and stored before use.…”

Section: Calibration Standard Solutionsmentioning

confidence: 99%

Development of Gas Chromatography/Mass Spectrometry for the Determination of Essential Fatty Acids in Food Supplemental Oil Products

Ahn¹,

Yim²,

Kim³

2013

Mass Spectrometry Letters

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A gas chromatography/ mass spectrometric (GC/MS) method was developed as a candidate reference method for the accurate determination of essential fatty acids (linoleic acid, α-and γ-linolenic acids) in food supplemental oil products. Samples were spiked with three internal standards (stearic acid-d 35 , 13C 18 -linoleic acid, and 13C 18 -α-linolenic acid). Samples were then subject to saponification, derivatization for methylation, and extraction by organic solvent. For GC/MS measurement, an Agilent HP-88 column, designed for the separation of fatty acid methyl esters, was selected after comparing with other columns as it provided better separation for target analytes. Target analytes and internal standards were detected by selected ion monitoring of molecular ions of their methyl ester forms. The GC/MS method was applied for the measurement of three botanical oils in NIST SRM 3274 (borage oil, evening primrose oil, and flax oil), and measurement results agreed with the certified values. Measurement results for target analytes which have corresponding isotope-labeled analogues as internal standard were calculated based on isotope dilution mass spectrometry (IDMS) approach, and compared with results calculated by using the other two internal standards. Results from the IDMS approach and the typical internal standard approach were in good agreement within their measurement uncertainties. It proves that the developed GC/MS method can provide similar metrological quality with IDMS methods for the measurement of fatty acids in natural oil samples if a proper fatty acid is used as an internal standard.

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“…Our research laboratory at Korea Research Institute of Standards and Science as the National Metrology Institute of Korea has been developing food-matrix certified reference materials (CRMs) along with a higher-order reference method under a project of nutritional metrology program. (Lee et al, 2017;Lee et al, 2016;Lee et al, 2019b;Shin et al, 2013) The food-matrix CRMs provide certified values for the target nutrients and can be used to verify the nutrient measurements. Under this program, the IDMS methods have been developed as candidate reference methods for the quantitative analysis of individual nutrients in various foods.…”

Section: Introductionmentioning

confidence: 99%

Quantitative analyses of essential fatty acids in cereals and green vegetables by isotope dilution-gas chromatography/mass spectrometry

et al. 2020

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An analytical method for the accurate determination of essential fatty acids in cereals and green vegetables is established based on isotope dilution-gas chromatography/mass spectrometry (ID-GC/MS). In this approach, 13 Clabeled fatty acids were added as internal standards to the samples prior to the sample preparation. Repeatability and reproducibility for the analyses of the essential fatty acids extracted from homogenized cereals and green vegetables were examined to validate the ID-GC/MS method. The repeatability and reproducibility were within 2% relative standard deviation. The developed method provides higher-order measurement results with the relative expanded uncertainties of 1-2% and 2-4% for cereals and green vegetables, respectively. Based on the fatty acid measurements, the developed ID-GC/MS method can be used as a candidate reference method for the quantitation of essential fatty acids in cereals and green vegetables. The developed method was also applied to analyze several commercially available products including cereal and vegetable powders.

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Investigation of isotope dilution mass spectrometric (ID-MS) method to determine niacin in infant formula, breakfast cereals and multivitamins

Cited by 20 publications

References 15 publications

Evolution of reference materials for the determination of organic nutrients in food and dietary supplements—a critical review

Evolution of reference materials for the determination of organic nutrients in food and dietary supplements—a critical review

Development of Gas Chromatography/Mass Spectrometry for the Determination of Essential Fatty Acids in Food Supplemental Oil Products

Quantitative analyses of essential fatty acids in cereals and green vegetables by isotope dilution-gas chromatography/mass spectrometry

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