Investigation of inflammation related gene polymorphism of the mannose-binding lectin 2 in schizophrenia and bipolar disorder

Yazar, Menekşe Sıla; Erol, Ayşe; Pehlıvan, Sacide

doi:10.17712/nsj.2021.4.20200050

Cited by 9 publications

(6 citation statements)

References 51 publications

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“…Experts in the field indicate that variations in many genes, each with a small effect, may combine to increase the risk of developing the condition. 3,4 As we mentioned in the last paragraph of the introduction part of the article, the genome-wide scan of BD and investigation of population stratification effects on linkage provided evidence supporting susceptibility loci at 4q21, 7q36, 9p21, 12q24, 14q24, and 16p13. 5 Since the NOS3 gene is also located in the 7q36, we investigated the association between clinical parameters of BD and the intron 4 VNTR variant in the NOS3 gene by comparing genotype distributions of patients with healthy controls.…”

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confidence: 82%

Comments on intron 4 VNTR polymorphism in theNOS3gene and bipolar disorder

Mungmunpuntipantip¹,

Wiwanitkit

2023

NSJ

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Comments on intron 4 VNTR polymorphism in the NOS3 gene and bipolar disorder To the EditorWe would like to discuss the recent publication by Aytac et al 1 entitled 'Association of intron 4 VNTR polymorphism in the NOS3 gene with rapid cycling and treatment resistance in bipolar disorder (BD): a case-control study. 1 While BD patients with the b/b genotype and b allele had a decreased risk of rapid cycling and treatment resistance, those with the b/a genotype were more at risk for these issues, according to Aytac et al. 1 Aytac et al 1 also noted that the BD group with the b/b genotype experienced statistically fewer hospitalizations and higher Clinical Global Impression-Improvement Scale scores than the BD group with the b/a and a/a genotypes. 1 The effect of the studied polymorphisms might be detected in the current report. However, it is important to discuss the confounding factors in the present study. At least, there are many genetic polymorphisms that might be related to BD. Examples are UGT1A4 and UGT2B7 Polymorphisms. 2 Further studies to assess the effect of those possible confounding polymorphisms should be performed.

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confidence: 82%

Comments on intron 4 VNTR polymorphism in theNOS3gene and bipolar disorder

Mungmunpuntipantip¹,

Wiwanitkit

2023

NSJ

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“…High mannose level at fasting have been associated with insulin resistance in diabetic individuals independent of obesity level 54 . In addition, MBL2 (encodes mannose-binding lectin 2), which is implicated in mannose metabolism, has been found to be associated with bipolar disorder in genetic studies, supporting the causal role of this metabolite in bipolar disorder [55][56][57] . Our analyses indicate that lower mannose levels were associated with higher risk for bipolar disorder patients, and thus prescribing mannose, an available supplemental substance, may be useful to study as a potential intervention for bipolar disorder.…”

Section: Insights Into Brain-related Phenotypes Using Genetically Reg...mentioning

confidence: 99%

Unique genetic architecture of CSF and brain metabolites pinpoints the novel targets for the traits of human wellness

Wang

Western

Yang

et al. 2023

Preprint

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Brain metabolism perturbation can contribute to traits and diseases. We conducted the first large-scale CSF and brain genome-wide association studies, which identified 219 independent associations (59.8% novel) for 144 CSF metabolites and 36 independent associations (55.6% novel) for 34 brain metabolites. Most of the novel signals (97.7% and 70.0% in CSF and brain) were tissue specific. We also integrated MWAS-FUSION approaches with Mendelian Randomization and colocalization to identify causal metabolites for 27 brain and human wellness phenotypes and identified eight metabolites to be causal for eight traits (11 relationships). Low mannose level was causal to bipolar disorder and as dietary supplement it may provide therapeutic benefits. Low galactosylglycerol level was found causal to Parkinson’s Disease (PD). Our study expanded the knowledge of MQTL in central nervous system, provided insights into human wellness, and successfully demonstrates the utility of combined statistical approaches to inform interventions.

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“…Schizophrenia (SCZ) and bipolar disorders (BD) are among the leading causes of disability worldwide, affecting around 1% of the population. However, biological mechanisms are still inadequately understood, where the interaction of environmental and genetic risk factors seems to play a prominent function in their etiology [1][2][3]. Moreover, expanding evidence has demonstrated that defects in immune-related genes present SCZ and BD susceptibility [4][5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Interleukin-1 receptor antagonist (IL-1RA) and interleukin-4 (IL-4) variable number of tandem repeat polymorphisms in schizophrenia and bipolar disorder: an association study in Turkish population

Pehlıvan

Oyacı

Tuncel

2022

Egypt J Med Hum Genet

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Background Pro-inflammatory/anti-inflammatory cytokine imbalance in cerebrospinal fluid or plasma of schizophrenia (SCZ) and bipolar disorder (BD) patients has been documented over the last decade. We aim to examine the interleukin-1 receptor antagonist (IL-1RA) and IL-4 variable number of tandem repeat (VNTR) polymorphisms in SCZ and BD patients by comparing them with healthy controls. Methods Two hundred and thirty-four unrelated patients (127 patients with SCZ, 107 patients with BD) and 204 healthy controls were included. The Structured Clinical Interview for DSM-IV Axis I Disorders was used to confirm the diagnosis. In addition, the polymerase chain reaction technique was used to investigate IL-1RA and IL-4 VNTR polymorphisms. Results Our results showed that the distributions of IL-1RA and IL-4 genotype and the allele frequencies of SCZ or BD patients were not significantly different from the healthy control group. IL-1RA allele 2 homozygous genotype and IL-1RA allele 2 frequencies were non-significantly higher among SCZ patients than in controls. Conclusions Our study indicates that the IL-1RA and IL-4 VNTR polymorphisms are not considered risk factors for developing SCZ and BD among Turkish patients.

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Investigation of inflammation related gene polymorphism of the mannose-binding lectin 2 in schizophrenia and bipolar disorder

Abstract: Objectives: To investigate the association between mannose-binding lectin 2 )MBL2( codon 54 polymorphism and clinical features of patients diagnosed with schizophrenia )SCZ( or bipolar disorder )BD(.

Cited by 9 publications

References 51 publications

Comments on intron 4 VNTR polymorphism in theNOS3gene and bipolar disorder

Comments on intron 4 VNTR polymorphism in theNOS3gene and bipolar disorder

Unique genetic architecture of CSF and brain metabolites pinpoints the novel targets for the traits of human wellness

Interleukin-1 receptor antagonist (IL-1RA) and interleukin-4 (IL-4) variable number of tandem repeat polymorphisms in schizophrenia and bipolar disorder: an association study in Turkish population

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