Investigation of inducing apoptosis in human lung cancer A549 cells and related mechanism of a ruthenium(II) polypyridyl complex

Chen, Jincan; Li, Guodong; Peng, Fa; Jie, Xin-ming; Guangzhi, Dongye; Zhong, Yu; Feng, Ruibing; Li, Baojun; Qu, Jiaoyue; Ding, Yan; Chen, Lanmei

doi:10.1016/j.inoche.2016.04.025

Cited by 23 publications

(15 citation statements)

References 23 publications

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“…In the last year, several ruthenium compounds have been synthetized, and their antiproliferative activities and mechanism of action against several tumors characterized [8,[37][38][39], where cell membrane changes, cell death due to intrinsic apoptosis pathway and/or autophagic pathway, ROS induction, inhibition of topoisomerase I and II might be the cause of their cytotoxicity/antiproliferative activities [8,[39][40][41][42][43][44]…”

Section: Rutheniummentioning

confidence: 99%

“…Some of these complexes appear to act by intercalation in the tumor cells, although in some cases it has been demonstrated that they can operate by DNA photocleavage [50][51][52]. Ruthenium complexes with polypyridine ligands such as 2,2-bipyridine (bpy), 1,10-phenanthroline (phen), and 2,2′:6,2″-terpyridine (terpy) ligands have been largely explored as molecular DNA probes due to their photophysical properties and the ability of polypyridyl ligands to intercalate with DNA [35,38,[53][54][55]. This type of ligands stabilizes the ruthenium metal ion in the oxidation state (II), resulting in solution-stable complexes of aqueous solution.…”

Section: Rutheniummentioning

confidence: 99%

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Inorganic Coordination Chemistry: Where We Stand in Cancer Treatment?

Pedrosa¹,

Carvalho²,

Baptista³

et al. 2018

Basic Concepts Viewed From Frontier in Inorganic Coordination Chemistry

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Metals have unique characteristics such as variable coordination modes, redox activity, and reactivity being indispensable for several biochemical processes in cells. Due to their reactivity, their concentration is tightly regulated inside the cells, and abnormal concentrations are associated with many disorders, such as cancer. As such metal complexes turned out to be very attractive as potential anticancer agents. The discovery of cisplatin was a crucial moment, which prompted the interest in Pt(II) and other metal complexes as potential anticancer agents. This chapter highlights the state of the art on metal complexes in cancer therapy, highlighting their uptake mechanisms, biological targets, toxicity, and drug resistance. Finally, based on the importance of selective target of cancer cells, drug delivery systems will also be discussed.

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Section: Rutheniummentioning

confidence: 99%

Section: Rutheniummentioning

confidence: 99%

Inorganic Coordination Chemistry: Where We Stand in Cancer Treatment?

Pedrosa¹,

Carvalho²,

Baptista³

et al. 2018

Basic Concepts Viewed From Frontier in Inorganic Coordination Chemistry

View full text Add to dashboard Cite

show abstract

“…16 In addition, these complexes have reduced toxicity and can be well tolerated in vivo. 17 Studies have also shown that most Ru complexes have low systemic toxicity, exhibit slow ligand exchange rates similar to that of platinum compounds, and can accumulate in cancer cells more effectively than platinum. The anticancer mechanisms of Ru complexes have been extensively investigated as illustrated in Table 2.…”

mentioning

confidence: 99%

Recent developments in the nanostructured materials functionalized with ruthenium complexes for targeted drug delivery to tumors

Thangavel

Viswanath

Kim

2017

IJN

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In recent years, the field of metal-based drugs has been dominated by other existing precious metal drugs, and many researchers have focused their attention on the synthesis of various ruthenium (Ru) complexes due to their potential medical and pharmaceutical applications. The beneficial properties of Ru, which make it a highly promising therapeutic agent, include its variable oxidation states, low toxicity, high selectivity for diseased cells, ligand exchange properties, and the ability to mimic iron binding to biomolecules. In addition, Ru complexes have favorable adsorption properties, along with excellent photochemical and photophysical properties, which make them promising tools for photodynamic therapy. At present, nanostructured materials functionalized with Ru complexes have become an efficient way to administer Ru-based anticancer drugs for cancer treatment. In this review, the recent developments in the nanostructured materials functionalized with Ru complexes for targeted drug delivery to tumors are discussed. In addition, information on “traditional” (ie, non-nanostructured) Ru-based cancer therapies is included in a precise manner.

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“…As O padrão isotópico comumente encontrado dos espectros de massa de compostos contendo rutênio em sua composição é marcado pela presença dos isótopos com suas respectivas abundâncias 96 Ru (5,5%), 98 Ru (1,9%), 99 Ru (12,7%), 100 Ru (12,6%), 101 Ru (17,1%), 102 Ru (31,6 %) e 104 alterações que culminam na morte celular, dentre elas a crescente geração de espécies reativas de oxigênio. [127][128][129][130] C o n c l u s ã o | 79…”

Section: Análise Elementar (Chns)unclassified

Efeito citotóxico contra células de câncer de pulmão de novos complexos de rutênio(II) contendo ligantes bifosfínicos, tiossemicarbazonas e semicarbazonas

Gonçalves¹

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I n t r o d u ç ã o | 7 RESUMO O presente trabalho descreve a síntese e caracterização físico-química de quatro complexos de rutênio(II) análogos e inéditos, contendo em suas esferas de coordenação ligantes bifosfínicos (dppm = 1,1-bis(difenilfosfina)metano e ligantes das classes tio e semicarbazonas cíclicas (5-metóxi-5,6-difenil-4,5-dihidro-2H-[1,2,4]triazina-3-tiona (Btsc) e 5-metóxi-5,6-difeniltriazina-3-ona (Bsc), para os complexos 1 e 2, respectivamente, e dppe = 1,1-bis(difenilfosfina)etano e os ligantes Btsc e Bsc, para os complexos 3 e 4, respectivamente). Os complexos foram caracterizados pelas técnicas de análise elementar, espectroscopia vibracional na região do infravermelho, espectroscopia de absorção na região do ultravioleta e visível, espectroscopia de ressonância magnética nuclear de 31 P{ 1 H} e 1 H, espectrometria de massas e difração de raios X por monocristal. A estabilidade dos complexos em dimetilsulfóxido (DMSO) foi estudada por meio da obtenção dos espectros de RMN 31 P{ 1 H} em diferentes intervalos de tempo. O estudo sugeriu que as ligações envolvidas na esfera de coordenação do metal, em todos os complexos, permanecem inalteradas durante o intervalo de tempo monitorado. Ensaios antitumorais in vitro contra a linhagem de células tumorais A549 e normais BEAS-2B foram realizados para todos os complexos, ambos precursores e ligantes livres e para cisplatina. Todos os complexos testados exibiram efeito citotóxico contra as células de câncer de pulmão, com valores de IC50 inferiores à cisplatina. Os novos complexos apresentaram valores muito similares na faixa de 0,26 a 0,52 μM, sendo o complexo 4 o mais ativo e mais seletivo dentre eles. Estudos teóricos de ancoragem molecular foram realizados com o intuito de prever e compreender as possíveis interações dos complexos 1-4 com o DNA. Palavras-chave: Complexos de rutênio(II). Câncer de pulmão. Tiossemicarbazonas.

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Investigation of inducing apoptosis in human lung cancer A549 cells and related mechanism of a ruthenium(II) polypyridyl complex

Cited by 23 publications

References 23 publications

Inorganic Coordination Chemistry: Where We Stand in Cancer Treatment?

Inorganic Coordination Chemistry: Where We Stand in Cancer Treatment?

Recent developments in the nanostructured materials functionalized with ruthenium complexes for targeted drug delivery to tumors

Efeito citotóxico contra células de câncer de pulmão de novos complexos de rutênio(II) contendo ligantes bifosfínicos, tiossemicarbazonas e semicarbazonas

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