Investigation of in-vitro biocompatibility and in-vivo biodegradability of AM series Mg alloys

Comba, Arzu; Çiçek, Bünyamin; Comba, Bahat; Sancak, Tunahan; Akveran, Gönül Arslan; Sun, Yavuz; Elen, Levent; Afshar, Milad Torkamanian

doi:10.1080/10667857.2022.2081115

Cited by 13 publications

(7 citation statements)

References 61 publications

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“…Mg can be used as a biodegradable material because Mg 2+ ions are synthesis activators of numerous protein branches and hormones in living tissue. Therefore, it is crucial to study the in-vitro and in-vivo bio-corrosion of different Mg alloys [17,18]. Mg biocorrosion is complex in the human body.…”

Section: Introductionmentioning

confidence: 99%

Insight into synergetic effects of serum albumin and glucose on the biodegradation behavior of WE43 alloy in simulated body fluid

et al. 2022

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The biodegradation rate of Mg alloy medical devices, such as screws and plates for temporary bone fracture fixation or coronary angioplasty stents, is an increasingly important area of study. In vitro models of the corrosion behavior of these devices use revised simulated body fluid (m-SBF) based on a healthy individual’s blood chemistry. Therefore, model outputs have limited application to patients with altered blood plasma glucose or protein concentrations. This work studies the biodegradation behavior of the Mg alloy, WE43, in m-SBF modified with varying concentrations of glucose and bovine serum albumin (BSA) to 1) mimic a range of disease states and 2) determine the contributions of each biomolecule to corrosion. Measurements include the Mg ion release rate, electrolyte pH, the extent of hydrogen evolution (as a proxy for corrosion rate), surface morphology, and corrosion product composition and effects. BSA (0.1 g L–1) suppresses the rate of hydrogen evolution (about 30%) after 24 h and—to a lesser degree—Mg2+ release in both the presence and absence of glucose. This effect gets more pronounced with time, possibly due to BSA adsorption on the Mg surface. Electrochemical studies confirm that adding glucose (2 g L–1) to the solution containing BSA (0.1 g L–1) caused a decrease in corrosion resistance (by around 40%), and concomitant increase in the hydrogen evolution rate (from 10.32-11.04 mg cm–2 d–1) to levels far beyond the tolerance limits of live tissues.

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Section: Introductionmentioning

confidence: 99%

Insight into synergetic effects of serum albumin and glucose on the biodegradation behavior of WE43 alloy in simulated body fluid

et al. 2022

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“…This indicates that a high-magnesium environment makes BMSCs express alkaline phosphatase. Many researchers have investigated the effects of Mg ions on various kinds of osteogenic cells − and demonstrated that increasing the Mg ion concentration enhanced the expression of osteogenic-related mRNA, such as alkaline phosphatase (ALP). The expression of Col-I in the Mg–6Zn–1Mn group is lower than that in the Mg–6Zn group because Mg ions promoted the expression of osteogenic differentiation markers in BMSCs, such as bone morphogenetic protein-2 (BMP-2) and collagen-1 (Col-l).…”

Section: Resultsmentioning

confidence: 99%

Degradation Adaptability Assessment of Semisolid Powder Molded Mg–Zn–Mn Alloys for Orthopedic Applications

Luo,

Li,

Cai

et al. 2023

ACS Appl. Bio Mater.

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“…İyon yoğunluğu, akım farkı vb. gibi değerlerin analizi ile korozyon direnci hesaplanabilmektedir [1], [7], [13]- [16].…”

Section: Introductionunclassified

MgAlSi Üçlü Alaşımının Üretimi ve in-vitro biyo Uyumluluk İncelemesi

SAĞIR,

ÇAKAL,

ELMACI

et al. 2023

Düzce Üniversitesi Bilim Ve Teknoloji Dergisi

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Bu çalışmada biyo uyumlu Mg metali ile birlikte Al ve Si elementlerini içeren bir alaşım üretilmiştir. Üretim işlemi indüksiyon ocağında ergiterek yapılmıştır. MgAlSi üçlü alaşımı üretim sonrasında 350C/12 saat homojenleştirme ısıl işlemine alınmıştır. Elde edilen numunelere mikro yapı incelemesi için taramalı elektron mikroskobu (SEM) kullanılmıştır. Biyo uyumluluk incelemeleri için daldırma korozyon, potansiyodinamik korozyon ve sitotoksisite (MTT) olmak üzere 3 farklı test ile uygulanmıştır. Korozyon testleri Hank’s solüsyonu içerisinde gerçekleştirilmiştir. pH dengesi ve % canlılık oranı analizleri ile temel biyouyumluluk şartlarını taşıdığı sonucuna varılmıştır. Böylece yapının biyo malzeme olarak kullanımı tartışılmıştır.

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Investigation of in-vitro biocompatibility and in-vivo biodegradability of AM series Mg alloys

Cited by 13 publications

References 61 publications

Insight into synergetic effects of serum albumin and glucose on the biodegradation behavior of WE43 alloy in simulated body fluid

Insight into synergetic effects of serum albumin and glucose on the biodegradation behavior of WE43 alloy in simulated body fluid

Degradation Adaptability Assessment of Semisolid Powder Molded Mg–Zn–Mn Alloys for Orthopedic Applications

MgAlSi Üçlü Alaşımının Üretimi ve in-vitro biyo Uyumluluk İncelemesi

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