Investigation of TCF7L2, LEP and LEPR polymorphisms with esophageal squamous cell carcinomas

Qiu, Hao; Lin, Xun-Ting; Tang, Weifeng; Liu, Chao; Chen, Yu; Ding, Hao; Kang, Myounggu; Chen, Shu-Chen

doi:10.18632/oncotarget.22619

Cited by 17 publications

(26 citation statements)

References 43 publications

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“…Nine were population-based,27,28,30,33,37,38,43,44,50 and 22 case–control were hospital-based studies 21,26,29,31,32,34–36,39–42,45–49,51–54. Of all the eligible studies, 11 focused on breast cancer,33,37–40,44,48,49,51,53 four focused on colorectal cancer (CRC),31,32,41,52 three focused on prostate cancer (PC),26,30,34 and 13 focused on other cancers 21,27–29,35,36,42,43,45–47,50,54. Other information includingd case–control studies in the pooled analysis is summarized in Table 1.…”

Section: Resultsmentioning

confidence: 99%

Leptin rs7799039 (G2548A) polymorphism is associated with cancer risk: a meta-analysis involving 25,799 subjects

Tang

Kang

Liu

et al. 2019

OTT

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Background: Leptin (LEP) is a human analogous form of the mouse obese gene and plays a critical role in energy expenditure as well as the progression of carcinogenesis. Many studies exploring the relationship between the LEP rs7799039 (G2548A) polymorphism and cancer risk have observed controversial results. To extensively evaluate this potential association, we conducted this meta-analysis. Methods: All eligible studies published up to August 2018 on the relationship between the LEP rs7799039 G>A polymorphism and cancer risk were obtained by searching PubMed, EMBASE, and the China Biology Medicine databases. The association of LEP rs7799039 G>A polymorphism with cancer risk was evaluated by crude ORs together with their 95% CI's. Results: Thirty-one case–control studies involving 25,799 subjects were included for meta-analysis. We identify a significant correlation with an overall cancer risk when these eligible case–control studies were pooled for analysis: for AA vs GG: an OR = 1.22, 95% CI = 1.01–1.48, P = 0.042 and for AA/GA vs GG: an OR = 1.16, 95% CI = 1.02–1.33, P = 0.026. A significant association was also detected in Asians, prostate cancer, other cancers, and hematopoietic malignancy subgroups. Sensitivity analysis was conducted by deleting an individual study in turn and calculation of the pooled ORs and CIs of the remainders. The results of sensitivity analyses indicated that no eligible study influenced the pooled ORs and CIs materially. Begg’s and Egger’s tests revealed that there was no evidence of publication bias. Conclusion: In conclusion, our study suggests that the LEP rs7799039 G>A polymorphism might contribute to the development of cancer. In order to further verify or refute our findings, large and well-designed epidemiological studies are needed.

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Section: Resultsmentioning

confidence: 99%

Leptin rs7799039 (G2548A) polymorphism is associated with cancer risk: a meta-analysis involving 25,799 subjects

Tang

Kang

Liu

et al. 2019

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“…The genotypes of BTLA rs16859629, rs1982809, rs2171513 and rs3112270 SNPs were analyzed using a SNPscan Kit (Genesky Biotechnologies Inc., Shanghai, China) as described previously [22][23][24]. PCR process was conducted in a 20-μl mixture volume in 96-well plates.…”

Section: Genotypingmentioning

confidence: 99%

Investigation of BTLA tagging variants with risk of esophagogastric junction adenocarcinoma

et al. 2019

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Background: Variants in B- and T-lymphocyte attenuator (BTLA) gene are likely to affect the function of BTLA protein. Methods: In the present case–control study, we selected BTLA tagging single-nucleotide polymorphisms (SNPs) (rs16859629 T>C, rs1982809 G>A, rs2171513 G>A and rs3112270 A>G) and conducted a case–control study to identify the association of BTLA SNPs with risk of esophagogastric junction adenocarcinoma (EGJA). The present study involved 1236 new incident EGJA cases and 1540 cancer-free controls. Results: The genotypes of BTLA SNPs were analyzed using a SNPscan Kit. No association was also found between the BTLA SNPs and the susceptibility of EGJA in overall comparsion. In subgroup analyses, the BTLA rs1982809 was found to be associated with an increased susceptibility of EGJA (AA versus GG: ORadjusted = 2.09, 95% CI 1.08–4.07, P = 0.030; and AA versus GA/GG: ORadjusted = 1.99, 95% CI 1.04–3.82, P = 0.039). In haplotype comparison, we identified that TAAG haplotype with the order of BTLA rs16859629, rs1982809, rs2171513 and rs3112270 SNPs might increase the susceptibility of EGJA (OR = 3.07, 95% CI = 1.41–6.71; P = 0.003). Conclusion: To conclude, the present study suggests that BTLA Trs16859629Ars1982809Ars2171513Grs3112270 haplotype may increase the susceptibility of EGJA. More studies should be conducted to evaluate whether BTLA polymorphisms may influence the susceptibility of cancer in the future.

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“… 35 As for esophageal cancer, an Australian study showed LEP G19A polymorphism was inactive for esophageal carcinogenesis, 36 which was in line with the findings of a Chinese study. 37 However, another Chinese study indicated that LEP G19A polymorphism contributed to less risk for esophagogastric junction adenocarcinoma. 38 As for prostate cancer, two studies obtained it was not heavily associated with LEP G19A polymorphism.…”

Section: Discussionmentioning

confidence: 99%

“…This polymorphism was correlated to cancer risk. [33][34][35][36][37][38][39][40][41][42][43][44][45] However, the existing findings in different types of cancers are discrepant. Furthermore, no researchers have studied the relationship between G19A polymorphism and the risk of GC.…”

Section: Introductionmentioning

confidence: 99%

A Variant of Leptin Gene Decreases the Risk of Gastric Cancer in Chinese Individuals: Evidence from a Case–Control Study

Ma¹,

He²

2020

PGPM

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Background: A host of studies have explored the potential connection between leptin (LEP) G19A polymorphism and the risk of cancers, but the relationship between gastric cancer (GC) susceptibility and LEP G19A polymorphism was not revealed before. The aim of this study was to investigate this relationship in Chinese Han population. Methods: Thus, this case-control study with 380 GC cases and 465 controls was designed to unearth the link between LEP G19A polymorphism and GC susceptibility. Genotyping was accomplished by a custom-made 48-Plex SNP scanTM kit. Relative LEP gene expression was detected by real-time reverse transcription-polymerase chain reaction. Results: LEP G19A polymorphism was shown to relate with a decreased risk of GC. Subgroup analyses uncovered significant connections in the males, nondrinkers, and those at age <60 years. G19A polymorphism was also linked with tumor size and location and pathological type of GC. Last, LEP gene expression in gastric tissues was considerably less than in control tissues. Conclusion: This study shows that G19A polymorphism of LEP gene is linked with a lower risk of GC in the tested Chinese Han individuals.

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Investigation of TCF7L2, LEP and LEPR polymorphisms with esophageal squamous cell carcinomas

Cited by 17 publications

References 43 publications

<p>Leptin rs7799039 (G2548A) polymorphism is associated with cancer risk: a meta-analysis involving 25,799 subjects</p>

<p>Leptin rs7799039 (G2548A) polymorphism is associated with cancer risk: a meta-analysis involving 25,799 subjects</p>

Investigation of BTLA tagging variants with risk of esophagogastric junction adenocarcinoma

<p>A Variant of <em>Leptin</em> Gene Decreases the Risk of Gastric Cancer in Chinese Individuals: Evidence from a Case–Control Study</p>

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