Investigation of human leukocyte antigen in osteoarticular brucellosis

Abstract

Background/aim: To determine the relationship between human leukocyte antigen (HLA) antigens and osteoarticular brucellosis by evaluating HLA Class I and II antigens in control subjects and patients developing osteoarticular brucellosis in Turkey. Materials and methods:The study included 28 patients with osteoarticular involvement diagnosed with brucellosis and 100 controls. The HLA Class I and II antigens were studied in isolated DNA samples using sequence-specific oligonucleotide procedure. Results:The mean age of the 28 patients and 100 controls was 42.3 ± 20.2 years and 50.1 ± 16.3 years, respectively. When the frequency of HLA Class I was examined, HLA-A*02 and HLA-B*27 antigens were detected in 50% and 28.57% of the patients, respectively. However, there was no significant difference when compared to the control group. Among the HLA Class I antigens, HLA-Cw*10 was determined in 35.71% of the patients and 17% of the controls; the difference was significant (P = 0.039). Conclusion:In the development of brucellosis, the frequency of HLA-Cw*10 among HLA Class I antigens was observed to be increased, and HLA-Cw*10 was considered likely to cause predisposition to brucellosis. Further studies to be performed on a higher number of patients and controls could demonstrate that genetic factors play a role in the diagnosis of osteoarticular brucellosis.

Improved Early Detection of Focal Brucellosis Complications with Anti- Brucella IgG

“…infection in humans that causes damage to one or more organs or systems (9,12,15). Distinguishing focal brucellosis from focal infection induced by other pathogens is difficult, posing a challenge in the administration of effective medication (19,20). Therefore, it is critical to understand the incidence and manifestations of complicated brucellosis and to identify biomarkers that can detect the occurrence of focal infection.…”