The combined effect of roughness and suction/blowing in laminar micro-channel flow was investigated numerically to determine whether turbulence can be generated and maintained at low Reynolds numbers. The square bar elements are mounted on the channels' bottom wall; slits are cut on the bars to suck and blow. Two cases are considered: one when the bars span the entire width of the channel, the second when they span along half of the width. The numerical study was performed using the Finite Volume Method (FVM). Different configurations of suction and blowing at different rates are considered. The results showed that the second case leads to generate secondary motions that disturb the laminar flow pattern.