Investigation of Group A Streptococcal Interactions with Host Glycan Structures Using High-Throughput Techniques: Glycan Microarray Analysis Using Recombinant Protein and Whole Cells

Indraratna, Anuk; Oliveira, David M. P. De; Hartley-Tassell, Lauren E.; Day, Christopher J.; Walker, Mark J.; Jennings, Michael P.; Sanderson-Smith, Martina L.

doi:10.1007/978-1-0716-0467-0_10

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Immune Evasion1

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2022

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“…Later research employing glycan microarray analysis, a technique increasingly utilised in GAS-glycome research (Indraratna et al . 2020 ), revealed that SLO binds a range of host glycans, with especially high affinity for B antigen type IV pentasaccharide (Shewell et al . 2020 ).…”

Section: Immune Evasionmentioning

confidence: 99%

The exploitation of human glycans by Group AStreptococcus

Indraratna

Everest‐Dass

Skropeta

et al. 2022

FEMS Microbiology Reviews

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Host carbohydrates, or glycans, have been implicated in the pathogenesis of many bacterial infections. Group A Streptococcus (GAS) is a Gram-positive bacterium that readily colonises the skin and oropharynx, and is a significant cause of mortality in humans. While the glycointeractions orchestrated by many other pathogens are increasingly well-described, the understanding of the role of human glycans in GAS disease remains incomplete. Although basic investigation into the mechanisms of GAS disease is ongoing, several glycointeractions have been identified and are examined herein. The majority of research in this context has focussed on bacterial adherence, however glycointeractions have also been implicated in carbohydrate metabolism; evasion of host immunity; biofilm adaptations; and toxin-mediated haemolysis. The involvement of human glycans in these diverse avenues of pathogenesis highlights the clinical value of understanding glycointeractions in combatting GAS disease.

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Section: Immune Evasionmentioning

confidence: 99%