Investigation of glycosaminoglycan mimetic scaffolds for neurite growth

Menezes, Roseline; Hashemi, Sharareh; Vincent, Richard; Collins, George; Meyer, James R.; Foston, Marcus; Arinzeh, Treena Livingston

doi:10.1016/j.actbio.2019.03.024

Cited by 26 publications

(19 citation statements)

References 55 publications

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“…Other studies demonstrated that sulfation of cellulose significantly enhanced the interaction of scaffold materials with other growth factors, such as neuronal growth factor NGF comparing chondroitin A and C sulfated with lower (only at the 6‐O‐position of AGU) and fully sulfated CS. [ 122 ] It was observed that binding of NGF increased with total DS S , which was the highest for fully sulfated CS and led to maximum outgrowth of neurites. The findings that CS promotes the activity of growth factors and cells are strongly in line with statements on the activity of GAGs toward growth factors being dominated by ionic interactions.…”

Section: Ionic Compounds Based On Cellulose Derivatives and Their Applications As Biomaterialsmentioning

confidence: 99%

Recent Progress on Cellulose‐Based Ionic Compounds for Biomaterials

Yang

Zeng

et al. 2020

Advanced Materials

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Cellulose and hemicelluloses represent the most abundant biomaterials on the Earth and represent major structural components in cell walls of plant that provide them with sufficient mechanical Glycans play important roles in all major kingdoms of organisms, such as archea, bacteria, fungi, plants, and animals. Cellulose, the most abundant polysaccharide on the Earth, plays a predominant role for mechanical stability in plants, and finds a plethora of applications by humans. Beyond traditional use, biomedical application of cellulose becomes feasible with advances of soluble cellulose derivatives with diverse functional moieties along the backbone and modified nanocellulose with versatile functional groups on the surface due to the native features of cellulose as both cellulose chains and supramolecular ordered domains as extractable nanocellulose. With the focus on ionic cellulose-based compounds involving both these groups primarily for biomedical applications, a brief introduction about glycoscience and especially native biologically active glycosaminoglycans with specific biomedical application areas on humans is given, which inspires further development of bioactive compounds from glycans. Then, both polymeric cellulose derivatives and nanocellulose-based compounds synthesized as versatile biomaterials for a large variety of biomedical applications, such as for wound dressings, controlled release, encapsulation of cells and enzymes, and tissue engineering, are separately described, regarding the diverse routes of synthesis and the established and suggested applications for these highly interesting materials.

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Section: Ionic Compounds Based On Cellulose Derivatives and Their Applications As Biomaterialsmentioning

confidence: 99%

Recent Progress on Cellulose‐Based Ionic Compounds for Biomaterials

Yang

Zeng

et al. 2020

Advanced Materials

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“…Native CS variants CS‐A and CS‐C were used as controls. [ 431 ] Whereas NGF binding was higher in scaffolds containing either of the sCel variants, neurite outgrowth from dorsal root ganglion explants was highest in fully sulfated cellulose. Decreased neurite outgrowth was detected in scaffolds containing partially sulfated cellulose, followed by CS‐C and CS‐A, respectively.…”

Section: Biological Properties and Biomedical Applications Of Espsmentioning

confidence: 99%

“…This indicated that the alignment of electrospun fibers supports neurite outgrowth, with a positive correlation between neurite length and the degree of sulfation. [431] McCanney et al reported another approach to tackling the lack of endogenous repair and glial scar formation by elevated astrocyte recruitment following a spinal cord injury. [432] Here, a library of selectively 2-O-and/or www.afm-journal.de www.advancedsciencenews.com…”

Section: (33 Of 52)mentioning

confidence: 99%

Engineered Sulfated Polysaccharides for Biomedical Applications

Arlov

Rütsche

Korayem

et al. 2021

Adv Funct Materials

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Sulfated polysaccharides are ubiquitous in living systems and have central roles in biological functions such as organism development, cell proliferation and differentiation, cellular communication, tissue homeostasis, and host defense. Engineered sulfated polysaccharides (ESPs) are structural derivatives not found in nature but generated through chemical and enzymatic modification of natural polysaccharides, as well as chemically synthesized oligo‐ and polysaccharides. ESPs exhibit novel and augmented biological properties compared with their unmodified counterparts, mainly through facilitating interactions with other macromolecules. These interactions are closely linked to their sulfation patterns and backbone structures, providing a means to fine‐tune biological properties and characterize structural–functional relationships by employing well‐characterized polysaccharides and strategies for regioselective modification. The following review provides a comprehensive overview of the synthesis and characterization of ESPs and of their biological properties. Through the pioneering research presented here, key emerging application areas for ESPs, which can lead to novel breakthroughs in biomedical research and clinical treatments, are highlighted.

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“…Two images in three different areas of each scaffold were captured. Fiber diameters and inter-fiber spacing were measured at n = 15 per image using ImageJ software, as previously described 46 . Degree of alignment for aligned fiber matrices was measured as previously described 46 .…”

Section: Sem Of Scaffoldsmentioning

confidence: 99%

“…Fiber diameters and inter-fiber spacing were measured at n = 15 per image using ImageJ software, as previously described 46 . Degree of alignment for aligned fiber matrices was measured as previously described 46 . Briefly, a line was drawn perpendicular to a fiber, chosen at random, in the SEM image.…”

Section: Sem Of Scaffoldsmentioning

confidence: 99%

Artificial scaffolds that mimic the plant extracellular environment for the culture and attachment of plant cells

Calcutt

Vincent

Dean

et al. 2020

Preprint

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Plant growth and development involves an intricate program of cell division and cell expansionto generate different cell types, tissue patterns and organ shapes. Plant cells are stuck together by their cell walls and the spatial context of cells within tissues plays a critical role in cell fate specification and morphogenesis. An in vitro model system to study plant development and its regulation by various extrinsic and intrinsic factors requires the ability to mimic the physical interactions between cells and their environment. Here, we present a set of artificial scaffolds to which cultured tobacco BY-2 cells adhere without causing morphological abnormalities. These scaffolds mimic native plant cell walls in terms of their fibrous nature, charge, hydrophobicity and piezoelectricity. We found that the extent of plant cell adhesion was essentially insensitive to the stiffness, fiber dimension, and fiber orientation of the scaffolds, but was affected by the piezoelectric properties of scaffolds where adhesion increased on piezoelectric materials. We also found that the plant cell wall polysaccharide, pectin, is largely responsible for adhesion to scaffolds, analogous to pectin-mediated adhesion of plant cells in tissues. Together, this work establishes biomimetic scaffolds that realistically emulate the plant tissue environment and provide the capability to develop microfluidic devices to study how cell-cell and cell-matrix interactions affect plant developmental pathways.

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Investigation of glycosaminoglycan mimetic scaffolds for neurite growth

Cited by 26 publications

References 55 publications

Recent Progress on Cellulose‐Based Ionic Compounds for Biomaterials

Recent Progress on Cellulose‐Based Ionic Compounds for Biomaterials

Engineered Sulfated Polysaccharides for Biomedical Applications

Artificial scaffolds that mimic the plant extracellular environment for the culture and attachment of plant cells

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