Investigation of global developmental delay

Magnetic Resonance Imaging (MRI) Evaluation of Developmental Delay in Pediatric Patients

“…MR imaging is an important part of the comprehensive evaluation of children with developmental delay, as many specific aetiologic and pathophysiologic conditions that lead to developmental delay can be detected easily [14][15][16][17][18]. …”

Investigating early developmental impairment: what’s the cost?

“…It is worth asking ‘what is the cost of these investigations?’ Curry’s 1997 recommendation for first--line investigations cost approximately £380/patient,2 assuming microarray is performed rather than karyotype, compared with £472.42/patient for McDonald’s 2006 guideline,3 £491.34/patient for Horridge’s 2011 recommendations4 and £567.28 for our local guidelines (table 1). These figures are for first-line investigations and do not include MRI.…”

Global Developmental Delay in a Mexican Patient With Megalencephalic Leukoencephalopathy With Subcortical Cysts

“…In approximately 50% -60% of cases, as in the present case, MRI reveals the cause of the global developmental delay (4). MLC exhibits very specific characteristics on MRI (7-11).…”

“…MLC exhibits an autosomal recessive mode of inheritance. Two genes have been found to be associated with MLC, including MLC1, which is present in 80% of cases (4). There is no knowledge about the incidence of MLC.…”