Investigation of Gastroprotective Potential of Grape Seed Proanthocyanidin Exract in Experimental Models of Gastric Ulcer, in Wistar Rats

Bhardwaj, Vivek; Bhardwaj, Rajat; Reddy, Bandugula Venkata; Sharma, Pankaj

doi:10.4172/2161-069x.1000561

Cited by 7 publications

(4 citation statements)

References 41 publications

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“…In the current study a significant depletion of colon tissue L-MDA, and marked increase in CAT activity and GSH concentrations were observed after administration of Proanthocyanidin in colon ulcer-induced rats. Similarly, Bhardwaj et al, (2018) recorded that, rats treated with GSPE produced a significant reduction of MDA levels and increased the anti-oxidant levels like CAT, SOD and GSH. Also, Pcs pretreatment significantly reduced MPO level in ulcerated rats, suggesting the ability of Pcs to prevent neutrophil infiltration in ulcerated colon tissue.…”

Section: Discussionmentioning

confidence: 79%

The potential Anti-Inflammatory and antioxidant activities of Proanthocyanidins in acetic acid–induced ulcerative colitis in rats

Hussein

Zaid

Latif

et al. 2019

Benha Veterinary Medical Journal

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The present study was designed to investigate the anti-colitic effect of Proanthocyanidins (Pcs) in acetic acid -induced ulcerative colitis in rats.Forty male albino rats (220-250 g) were divided into five equal groups of 8 rats each. Group I: (Control normal group) rats received no drugs. Group II: (Early ulcerative colitis-induced group): rats received 2 ml (3% v/v) glacial acetic acid intracolonially at 21 th day from experiment and sacrificed 3 days later of acetic acid administration. Group III: (Late ulcerative colitis-induced group) rats received glacial acetic acid similar to group II for 3 successive days and sacrificed after 21 days. Group IV: (Early ulcerative colitis + Proanthocyanidins protected group) rats received Proanthocyanidins (200 mg/kg body weight/day) orally for 21 days prior to glacial acetic acid administration for 3 days, then the animals were sacrificed. Group V: (Late ulcerative colitis + Proanthocyanidins treated group) rats first administered with glacial acetic acid then after 3 days Proanthocyanidins was administered for 21 days. A significant increase in L-Malondialdehyde (L-MDA) and Myeloperoxidase (MOP) activity with marked decrease in reduced glutathione (GSH) and Catalase (CAT) activity in colon tissue of UC-induced rats as compared with control normal group. However, a significant depletion of colon tissue L-MDA, MOP activity and marked increase in GSH concentrations and CAT activity were observed after Proanthocyanidins treatment compared to ulcerated untreated rats. The quantification real time PCR (qPCR) results revealed a significant up-regulation of mRNA gene expression levels of Tumor necrosis factor alpha (TNF-α), Cyclooxygenase-2 (COX-2) and a significant down-regulation in Transforming growth factor -β1 (TGF-β1) in colon of acetic acid -induced colon ulcer in rats. The expression levels of TNF-α, COX-2 were significantly down-regulated and a significant up-regulated in TGF-β1 in colon tissues after administration of Pcs. Proanthocyanidins (Pcs) protect rats colon mucosa damage against acetic acid -induced ulcerative colitis via antiinflammatory and anti-oxidative mechanisms.

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Section: Discussionmentioning

confidence: 79%

The potential Anti-Inflammatory and antioxidant activities of Proanthocyanidins in acetic acid–induced ulcerative colitis in rats

Hussein

Zaid

Latif

et al. 2019

Benha Veterinary Medical Journal

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“…The gastroprotective effect of several fruit by-products was studied, such as orange bagasse [ 138 ], passion fruit peels [ 138 ], grape pomace [ 139 ], grape peels [ 140 ], grape seed [ 141 ], pomegranate by-products [ 142 , 143 , 144 ], orange peels [ 145 ], apple peels [ 146 ], apple pomace [ 147 , 148 ] ( Table 6 ).…”

Section: Fruit By-products and Intestinal Functionmentioning

confidence: 99%

“…A 100 mg/kg dose of grape seed proanthocyanidin showed better treatment of gastric ulcers with fewer side effects. This effect was observed by the significant decrease in ulcer index and gastric acidity in pylorus ligation models, as well as the reduction in MDA (malondialdehyde) levels [ 141 ].…”

Section: Fruit By-products and Intestinal Functionmentioning

confidence: 99%

The Role of Fruit by-Products as Bioactive Compounds for Intestinal Health

Chaouch

Benvenuti

2020

Foods

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The fruit processing industry generates large amounts of wastes (pomace, seeds, peels) that causes negative environmental impact with considerable treatment expenses. Nevertheless, various studies demonstrated that these by-products are still rich in bioactive compounds, especially dietary fibres and phenolic compounds, thus leading to significant chemical, physical and biological properties. These characteristics make fruits by-products a good source for new supplements in food products having important effect on intestinal function. Thus, the aim of this review is to evaluate the different bioactive compounds isolated from fruit by-products and to analyse their application in various formulations for the food and nutraceutical industries. In consideration of the biological properties of these compounds, their role in the functioning and action on intestine and gut flora was discussed.

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“…(1,2) Se han puesto en evidencia métodos para prevención de complicaciones de enfermedad péptica, dentro de lo más reciente se encuentra el manejo con semilla de uva, la cual muestra una tasa alta de mejoría en modelos experimentales, sin embargo, no hay evidencia clínica en pacientes y nuevos medicamentos inhibidores de la bomba de protones que se agregan al tratamiento convencional. (3,4) Dentro de los sitios de perforación, duodeno es el más frecuente seguido de píloro y antro, (1,5) es importante el manejo médico-quirúrgico establecido en este padecimientos teniendo en cuenta el tiempo de evolución, comorbilidades, probable causa etiológica, y estado clínico y hemodinámico de paciente, siendo este uno de los principales criterios para establecer el abordaje quirúrgico adecuado. (6) Para evidenciar y poder diferenciar el grado de lesión en la ulcera gástrica se utiliza la clasificación de Johnson (Cuadro I).…”

Section: Introductionunclassified

Reparación de ulcera gástrica prepilorica y duodenal reporte de caso

Aponte-de La Rosa,

Torres-Alvarez,

Navarro-Vidaña

et al. 2021

RSM

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INTRODUCCIÓN: La enfermedad péptica es una patología con una etiología multifactorial, y con complicaciones agudas como la hemorragia y la perforación la cual amerita tratamiento quirúrgico urgente, se estima que presenta una mortalidad entre el 10 % y 40 % especialmente en pacientes de edad avanzada. Los sitios de perforación duodeno es el más frecuente seguido de píloro y antro. OBJETIVO: El objetivo principal es el dar a conocer el manejo quirúrgico, la evolución y el seguimiento de una perforación gástrica.MATERIALES Y MÉTODOS Paciente femenino de 74 años con antecedentes de ingesta de medicamentos como ketorolaco y Saridon desde hace aproximadamente 30 años, casi diariamente, quien presenta dolor abdominal difuso, tipo cólico de inicio súbito.RESULTADOS: Paciente, presento una evolución adecuada evidenciada por el tiempo de estancia intrahospitalaria que fue de 12 días, no presento infecciones intra -hospitalarias, no presento fugas anastomóticas, mejoro estado séptico de ingreso.DISCUSIÓN: Los hallazgos de una doble perforación, una duodenal y una gástrica pre-pilórica las cuales son el primer y segundo lugar en frecuencia de localización, impidieron manejo convencional optando por un procedimiento que fue un cierre primario de perforación duodenal, exclusión pilórica y gastro-yeyuno anastomosis en omega de Braun mecánica.

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Investigation of Gastroprotective Potential of Grape Seed Proanthocyanidin Exract in Experimental Models of Gastric Ulcer, in Wistar Rats

Cited by 7 publications

References 41 publications

The potential Anti-Inflammatory and antioxidant activities of Proanthocyanidins in acetic acid–induced ulcerative colitis in rats

The potential Anti-Inflammatory and antioxidant activities of Proanthocyanidins in acetic acid–induced ulcerative colitis in rats

The Role of Fruit by-Products as Bioactive Compounds for Intestinal Health

Reparación de ulcera gástrica prepilorica y duodenal reporte de caso

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