Entropy generation in the receiver tube of a parabolic trough solar collector can mainly be attributed to the fluid friction and finite temperature differences. The contribution of each of these components is investigated under different circumstances. Mass flow rates, tube diameters and operating pressures are investigated to obtain good guidelines for receiver tube and plant design. Operating pressures between 3 MPa (saturation temperature of 233.9 °C) and 9 MPa (saturation temperature of 303.3 °C) were investigated.Results show that small diameters can result in excessive fluid friction, especially when the mass flow rates are high. For most cases, tube diameters beyond 20 mm will exclusively be subject to entropy generation due to finite temperature differences, and entropy generation due to fluid friction will be small to negligible. Increasing the concentration ratio will decrease entropy generation, due to a higher heat flux per unit meter. This will ultimately result in shorter receiver tube lengths. From a simulated annealing (SA) optimization it was seen that if the diameter is increased, the entropy generation can be lowered, provided that the concentration ratio is kept constant. However, beyond a certain point gains in minimizing the entropy generation become negligible. The optimal operating pressure will generally increase if the mass flow rate is increased. Finally it was seen that higher operating pressures are more advantageous when the entropy generation minimization is considered in conjunction with the work output.