Investigation of Flexible Arrayed Lactate Biosensor Based on Copper Doped Zinc Oxide Films Modified by Iron–Platinum Nanoparticles

Abstract

Potentiometric biosensors based on flexible arrayed silver paste electrode and copper-doped zinc oxide sensing film modified by iron-platinum nanoparticles (FePt NPs) are designed and manufactured to detect lactate in human. The sensing film is made of copper-doped zinc oxide (CZO) by a radio frequency (RF) sputtering system, and then modified by iron-platinum nanoparticles (FePt NPs). The surface morphology of copper-doped zinc oxide (CZO) is analyzed by scanning electron microscope (SEM). FePt NPs are analyzed by X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FTIR). The average sensitivity, response time, and interference effect of the lactate biosensors are analyzed by voltage-time (V-T) measurement system. The electrochemical impedance is analyzed by electrochemical impedance spectroscopy (EIS). The average sensitivity and linearity over the concentration range 0.2 mM–5 mM are 25.32 mV/mM and 0.977 mV/mM, respectively. The response time of the lactate biosensor is 16 s, with excellent selectivity.

Recent Advances in Wearable Biosensors for Non-Invasive Detection of Human Lactate

“…It was also possible to employ a screen-printed carbon electrode (SPCE) modified with a stable Fe 3+ solution to detect lactate with the linear response range of 1–180 mM [ 51 ]. To further enhance the performance of the sensor, a potentiometric biosensor based on a flexible array of silver paste electrodes and copper-doped zinc oxide (ZnO) sensing membranes modified by iron-platinum (Pt) nanoparticles (NPs) was fabricated for the detection of lactate in the human body with the detection range of 0.2–5 mM and sensitivity of 25.32 mV mM −1 [ 52 ].…”

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