Investigation of feasibility of singular value decomposition clutter filter in plane wave imaging with packet transmission sequence

Hasegawa, Hideyuki; Nagaoka, Ryo; Omura, Masaaki; Mozumi, Michiya; Saito, Kozue

doi:10.1007/s10396-020-01067-x

Cited by 15 publications

(18 citation statements)

References 20 publications

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“…Detailed explanations of such clutter filtering are described in Ref. [24]. We could observe the flow dynamics qualitatively from the visualized echoes from blood cells.…”

Section: Resultsmentioning

confidence: 88%

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Measurement of flow velocity vectors in carotid artery using plane wave imaging with repeated transmit sequence

et al. 2021

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Purpose Doppler-based methods are widely used for blood flow imaging in clinical settings. However, they inherently estimate the velocity component only in the axial direction. Therefore, various studies of angle-independent methods have been conducted. The multi-angle Doppler method is one such angle-independent method, in which the velocity vector is estimated using axial velocities obtained from multiple directions by steering an ultrasonic beam. Recently, plane wave imaging, which realizes a very high frame rate of several thousand frames per second, was applied to the multi-angle Doppler method. However, the maximum detectable velocity, i.e., the aliasing limit, was reduced depending on the number of steering angles. In the present study, the feasibility of a specific transmit sequence, namely, the repeated transmit sequence, was examined using the plane-wave multi-angle Doppler method. Method In the repeated transmit sequence, plane waves were emitted to the same direction twice, after which the steering angle was changed. By repeating the same procedure, a pair of beamformed radio-frequency (RF) signals could be obtained under each beam steering angle. By applying the autocorrelation method to each pair of RF signals, the time interval between the RF signals could be kept as the pulse repetition interval (PRI). The feasibility of such a transmit sequence was examined by numerical simulation and in vivo measurement of a human carotid artery. ResultsThe simulation results showed that the maximum steering angles of over 10 degrees were not feasible with the linear array used in the present study. The feasible maximum steering angle would depend on the element pitch of the probe relative to the ultrasonic wavelength. By limiting the maximum steering angles to 5 and 10 degrees, bias errors were 9.2% and 11.3%, respectively, and root mean squared errors were 21.5% and 16.9%, respectively. Also, flow velocity vectors in a human carotid artery could be visualized with the proposed method. ConclusionThe multi-angle Doppler method was implemented in plane wave imaging with the repeated transmit sequence, and the proposed method was shown to be feasible through numerical simulation and in vivo measurement of a carotid artery.

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“…Detailed explanations of such clutter filtering are described in Ref. [24]. We could observe the flow dynamics qualitatively from the visualized echoes from blood cells.…”

Section: Resultsmentioning

confidence: 88%

“…6. The SVD filter was designed so that it can be applicable to the repeated transmit sequence [24]. In the repeated transmit sequence, the number of transmissions in each packet is two, and it is not possible to use a clutter filter within a packet as is used in conventional color flow imaging.…”

Section: Resultsmentioning

confidence: 99%

Measurement of flow velocity vectors in carotid artery using plane wave imaging with repeated transmit sequence

et al. 2021

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“…For the detection of contrast signals, a relatively lower singular value threshold is chosen to filter out the unwanted tissue and noise signals. 39 ■ PRECLINICAL AND CLINICAL APPLICATIONS Ultrasound molecular imaging has shown its great potential in the early detection of tumors, imaging monitoring during treatments, and drug delivery and therapy. To date, there are a number of preclinical and clinical applications being explored to accelerate the clinical translation.…”

Section: ■ Advanced Detection Techniquesmentioning

confidence: 99%

“…D is a diagonal matrix that contains elements which are the singular values. For the detection of contrast signals, a relatively lower singular value threshold is chosen to filter out the unwanted tissue and noise signals …”

Section: Advanced Detection Techniquesmentioning

confidence: 99%

Ultrasound Molecular Imaging and Its Applications in Cancer Diagnosis and Therapy

Zhang

Sun

et al. 2022

ACS Sens.

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Ultrasound imaging is regarded as a highly sensitive imaging modality used in routine clinical examinations. Over the last several decades, ultrasound contrast agents have been widely applied in ultrasound molecular cancer imaging to improve the detection, characterization, and quantification of tumors. To date, a few new potential preclinical and clinical applications regarding ultrasound molecular cancer imaging are being investigated. This review presents an overview of the various kinds of ultrasound contrast agents employed in ultrasound molecular imaging and advanced imaging techniques using these contrast agents. Additionally, we discuss the recent enormous development of ultrasound contrast agents in the relevant preclinical and clinical applications, highlight the recent challenges which need to be overcome to accelerate the clinical translation, and discuss the future perspective of ultrasound molecular cancer imaging using various contrast agents. As a highly promising and valuable tumor-specific imaging technique, it is believed that ultrasound molecular imaging will pave an accurate and efficient way for cancer diagnosis.

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“…[12][13][14] Our previous study also evaluated blood flow dynamics in the numerical simulation and in vivo measurement using a block matching method under plane wave transmission at a single angle 15,16) and autocorrelation algorithm with the repeated transmission sequence for multi-angle plane wave imaging. 17,18) In the present study, an in vitro measurement system was developed for ultrafast ultrasound imaging to evaluate the appropriate flow conditions by synchronizing another velocimetry such as high-speed camera applications with laser illumination, i.e. optical particle image velocimetry (PIV).…”

Section: Introductionmentioning

confidence: 99%

Characterization of blood mimicking fluid with ultrafast ultrasonic and optical image velocimeters

Omura

Nagaoka

Yagi

et al. 2022

Jpn. J. Appl. Phys.

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A blood mimicking fluid (BMF) is imperative for the evaluation of Doppler ultrasound. Doppler ultrasound still causes errors due to some artifacts such as aliasing and presence of grating lobes. One of the other velocimeters is the optical particle image velocimeter (PIV). This study initially developed an in vitro measurement system for analyzing flowing BMF with ultrasonic and optical PIVs. The acoustic properties such as speed of sound, attenuation, and backscatter coefficient of BMF equivalent to the human blood, used for both ultrasonic and optical PIVs were analyzed in a frequency range of 4-12 MHz. The velocity profiles were estimated by ultrasonic and optical PIVs using a block matching method. A difference between velocities obtained by ultrasonic and optical data was within 4.0% using BMF with 20 µm polyamide particle at 0.2% concentration that realized the acoustic properties and speckle patterns similar to those in ultrafast ultrasound blood flow imaging.

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Investigation of feasibility of singular value decomposition clutter filter in plane wave imaging with packet transmission sequence

Cited by 15 publications

References 20 publications

Measurement of flow velocity vectors in carotid artery using plane wave imaging with repeated transmit sequence

Measurement of flow velocity vectors in carotid artery using plane wave imaging with repeated transmit sequence

Ultrasound Molecular Imaging and Its Applications in Cancer Diagnosis and Therapy

Characterization of blood mimicking fluid with ultrafast ultrasonic and optical image velocimeters

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