Investigation of fatty acid esters to replace isopropyl myristate in the sterility test for ophthalmic ointments

Cardoso, Valéria Macedo; Solano, Ana Gabriela Reis; Prado, Maria Auxiliadora Fontes; Nunan, Elzíria de Aguiar

doi:10.1016/j.jpba.2006.05.018

Cited by 9 publications

(7 citation statements)

References 10 publications

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“…In addition, several VOCs were detected more frequently among used samples, including nonanal (6 used, 1 new), isopropyl myristate (5 used, 0 new), and palmitic acid (2 used, 0 new). Nonanal, which was detected in 6 of the 11 used samples, is an alkyl aldehyde that is released by human skin and also found in building materials, while isopropyl myristate and palmitic acid are fatty acid esters that can be found in personal care products, such as lotions and ointments. , Because polyurethane foam has a high sorption capacity and can adsorb airborne VOCs over time, the compounds detected among the used samples may represent adsorbed VOCs that originated elsewhere in a residence rather than VOCs used in the production of the mattress.…”

Section: Resultsmentioning

confidence: 99%

Infant Exposure to Emissions of Volatile Organic Compounds from Crib Mattresses

Boor

Järnström²,

Novoselac

et al. 2014

Environ. Sci. Technol.

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Infants spend most of their time sleeping and are likely to be exposed to elevated concentrations of chemicals released from their crib mattresses. Small-scale chamber experiments were conducted to determine the area-specific emission rates (SERs) of volatile organic compounds (VOCs) in a collection of twenty new and used crib mattresses. All mattress samples were found to emit VOCs and the mean values of total VOC (TVOC) SERs were 56 μg/m(2)h at 23 °C and 139 μg/m(2)h at 36 °C. TVOC SERs were greater for new mattresses compared to used ones and were influenced by the type of foam material and the presence of mattress cover layer. A variety of VOCs were identified, with polyurethane foam releasing a greater diversity of VOCs compared to polyester foam. Large-scale chamber experiments were conducted with an infant thermal manikin. TVOC concentrations sampled in the breathing zone and interior pore air of the crib mattress foam were found to be greater than the bulk room air by factors in the range of 1.8 to 2.4 and 7.5 to 21, respectively. The results suggest that crib mattresses are an important source of VOCs and infant exposure to VOCs are possibly elevated in their sleep microenvironments.

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Section: Resultsmentioning

confidence: 99%

Infant Exposure to Emissions of Volatile Organic Compounds from Crib Mattresses

Boor

Järnström²,

Novoselac

et al. 2014

Environ. Sci. Technol.

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“…Isopropyl myristate (90) was found in all extracts of the P. avium by-products ( Table 3 ). The literature data showed that this VOC has a high toxicity against gram-negative microorganisms, and it is being suggested as a solvent for ointments [ 48 ].…”

Section: Resultsmentioning

confidence: 99%

Mineral Content and Volatile Profiling of Prunus avium L. (Sweet Cherry) By-Products from Fundão Region (Portugal)

Nunes

Gonçalves

Pinto

et al. 2022

Foods

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Large amounts of Prunus avium L. by-products result from sweet cherry production and processing. This work aimed to evaluate the mineral content and volatile profiling of the cherry stems, leaves, and flowers of the Saco cultivar collected from the Fundão region (Portugal). A total of 18 minerals were determined by ICP-MS, namely 8 essential and 10 non-essential elements. Phosphorus (P) was the most abundant mineral, while lithium (Li) was detected in trace amounts. Three different preparations were used in this work to determine volatiles: hydroethanolic extracts, crude extracts, and aqueous infusions. A total of 117 volatile compounds were identified using HS-SPME/GC-MS, distributed among different chemical classes: 31 aldehydes, 14 alcohols, 16 ketones, 30 esters, 4 acids, 4 monoterpenes, 3 norisoprenoids, 4 hydrocarbons, 7 heterocyclics, 1 lactone, 1 phenol, and 2 phenylpropenes. Benzaldehyde, 4-methyl-benzaldehyde, hexanal, lilac aldehyde, and 6-methyl-5-hepten-2-one were the major volatile compounds. Differences in the types of volatiles and their respective amounts in the different extracts were found. This is the first study that describes the mineral and volatile composition of Portuguese sweet cherry by-products, demonstrating that they could have great potential as nutraceutical ingredients and natural flavoring agents to be used in the pharmaceutical, cosmetic, and food industries.

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“…Antibacterial compounds in leaves extract were γ-Muurolene (Perigo et al 2016), 1-Tricosene (Susilo et al 2022), 2,4-Di-tert-butylphenol, 4-Di-tert-butylphenol (Aissaoui et al 2018) 9-Eicosene, (Lulamba et al 21021), α-Pinene (Rivas da Silva et al 2012;Dhar et al 2014). Cyclohexene, 4-methylene-1-(1 methylethyl)-or β-Terpinene (Guimarães et al 2019), Cyclopentaneacetic acid, 3-oxo-2-pentyl-, methyl ester (Shannon and Abu-Ghannam 2016), D-Limonene (Costa et al 2019;Han et al 2020), Ethylbenzene (Bellahcen et al 2019), Heptadecane, 8-methyl- (Ashraf et al 2018), Heptadecanoic acid, methyl ester (Mohadjerani et al 2016), Hexanedioic acid, bis(2-ethylhexyl) ester (alkane); Hexatriacontane (alkane) (Afzal et al 2014), Isopropyl myristate (Cardoso et al 2006), Methyl stearate (fatty acid methyl ester) (Agoramoorthy et al 2007), Nonadecane (Wijayanti and Dewi 2022), Oxalic acid, allyl hexadecyl ester (Dicarboxylic acid) (Zayed and Samling 2016), o-Xylene (Nimbeshaho et al 2020), Pentadecanoic acid, 14methyl-, methyl ester (Fatty-acid) (Yoon et al 2018), p-Xylene (Nimbeshaho et al 2020), Tetratetracontane (Agarwal et al 2017, Jamil et al 2021), and Tritetracontane (Martins et al 2015. While antibacterial compounds in rhizome were 1HCyclopenta [1,3] [3aS (3a.alpha., 3b.beta., 4.beta.,7.alpha., 7aS) or β-Cubebene (Constant et al 2019);1H-Cycloprop[e]azulen-7-ol, decahydro-1,1,7-trimethyl-4-methylene-, [1ar-(1a.alpha., 4a.alpha.,7.beta.,7a.beta.,7b.alpha.…”

Section: Phytochemical Profile Analysis Of N-hexane Extracts Of Etlin...mentioning

confidence: 99%

Antibacterial and phytochemical constituent of Etlingera rubroloba A.D. Poulsen extract, an endemic ginger from Wallacea Region, Indonesia

ANDILA

NUGROHO²

2022

Biodiversitas

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Abstract. Andila PS, Nugroho LH. 2022. Antibacterial and phytochemical constituent of Etlingera rubroloba A.D. Poulsen extract, an endemic ginger from Wallacea Region, Indonesia. Biodiversitas 23: 3646-3658. Etlingera rubroloba (Blume) AD Poulsen is one of the wild species of the Zingiberaceae which is a native and endemic species in the Wallacea region and has not been studied well for its biology and phytochemical potential. This study aimed to investigate the potential antibacterial activity of hexane extract from the leaves and rhizome of E. rubroloba and study their phytochemical content. The antibacterial activity test was carried out by the agar disc diffusion method against several human pathogenic bacteria and be measured for the Minimum Inhibitory Concentration (MIC) and Zone of inhibition. The phytochemical profile was tested for total phenol content (TPC), total flavonoid content (TFC) and GC-MS analysis. The study results show that TPC of E. rubroloba extracts respectively 15.68±0.80 mg Gallic Acid Equivalent (GAE)/g sample (leaves) and 11.89±0.76 mg GAE/g sample (rhizomes), while TFC value were 33.99±2.24 mg Quercetin Equivalent (QE)/g sample (leaves) and 32.46±0.67 mg QE/g sample (rhizomes). The antibacterial test revealed that E. rubroloba extracts were effective against Bacillus cereus ATCC11778 (with MIC value 0.5 mg/mL using leaves extract and 1 mg/mL in rhizomes), but it was not effective against Escherichia coli ATCC 25922, Staphylococcus aureus ATCC 25923 and Staphylococcus epidermidis ATCC12228. The hexane extracts of E. rubroloba contained a total of 28 and 58 compounds were identified in the leaf extract and rhizome, respectively. The dominant compounds in the leaf extract (Pentadecanoic acid, 14-methyl-, methyl ester; Methyl stearate) and in the rhizome extract (Hexadecanoic acid, ethyl ester; Isopropyl myristate; 9-Octadecenoic acid (Z)-, methyl ester; 9,12- Octadecadienoic acid, methyl ester, (E,E)-) is well known to have antibacterial activity. Based on the results of the antibacterial and phytochemical studies, it can be suggested that E. rubroloba has the potential as an antibacterial agent.

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Investigation of fatty acid esters to replace isopropyl myristate in the sterility test for ophthalmic ointments

Cited by 9 publications

References 10 publications

Infant Exposure to Emissions of Volatile Organic Compounds from Crib Mattresses

Infant Exposure to Emissions of Volatile Organic Compounds from Crib Mattresses

Mineral Content and Volatile Profiling of Prunus avium L. (Sweet Cherry) By-Products from Fundão Region (Portugal)

Antibacterial and phytochemical constituent of Etlingera rubroloba A.D. Poulsen extract, an endemic ginger from Wallacea Region, Indonesia

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