Investigation of factors related to periods to ipsilateral breast tumor recurrence after breast-conserving surgery and measures for preventing recurrence in early breast cancer

Abstract

Although tumor proliferative activity, ER status and ly caused differences in timing of recurrence, standard adjuvant therapy, particularly chemotherapy for early recurrence, was effective in inhibiting recurrence.

Endoscopy‐assisted breast‐conserving surgery for early breast cancer

“…The feasibility of E-BCS was evaluated in terms of the resection margin status, length of the operation time, blood loss, and postoperative complications. The resection margin status is a risk factor for local recurrence in patients with early breast cancer (15), and it may be a crucial factor for accessing the feasibility of E-BCS. According to previous reports, the resection margin positive rate for E-BCS was 0%-5% (11,12).…”

The Feasibility of Endoscopy-Assisted Breast Conservation Surgery for Patients with Early Breast Cancer

“…Resection margin status is a risk factor for local recurrence in patients with early breast cancer [14,15], and it may be a crucial factor for accessing EABCS feasibility. The resection margin positive rate for EABCS is 0-5% [5,6,10], compared with about a 10% margin positive rate for conventional BCS [1,16].…”

Predictors of Inflammatory Local Recurrence after Breast - Conserving Therapy for Breast Cancer : Matched Case-Control Study

“…Pathological risk factors for IBTR after BCS include close or positive surgical margins [1,3,12,16], presence of extensive intraductal component (EIC) in and/or around the tumor [1,[17][18], presence of lymphovascular invasion (LVI) with or without positive axillary lymph nodes [1,3,7,16,19], histological multifocality [7,16], high histopathological grade [16], negative hormonal receptor status [7], and c-erbB2 oncogene overexpression [20]. Clinical risk factors for IBTR include tumor size [16][17], young age [2][3][18][19], and gross multicentricity [9]; however, a strong family history of breast cancer has been associated with late IBTR and whether these are true recurrences or actually new tumors is controversial [21].…”

“…Some studies report an outcome similar to that reported for inflammatory breast cancer [23][24]; others describe "occult inflammatory breast cancer" as a more benign process. This type of recurrence has been associated with multicentricity [7,[10][11], multifocality [25][26], positive resection margins [7,16], high number of positive lymph nodes [7,25], and LVI [4,[7][8][12][13][14][15].…”

“…Late local recurrence (> 2 years) in a conserved breast can usually be treated by further surgery with curative intent and remains associated with a favorable prognosis [4][5]. Early local recurrence (< 2 years) may indicate a more aggres-sive clinicobiological behavior that heralds the appearance of distant metastases in many cases [1,[6][7]. A small but important subset of patients with local recurrence develops inflammatory local recurrence (ILR), which is associated with a distinctly poorer prognosis.…”