Investigation of Factors Influencing Release of Solid Drug Dispersed in Inert Matrices

Desai, Saurabh J.; Simonelli, Anthony P.; Higuchi, William I.

doi:10.1002/jps.2600541012

Cited by 206 publications

(57 citation statements)

References 2 publications

(1 reference statement)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The Higuchi model is an empirical model commonly used to describe the release kinetics of drugs from insoluble porous materials [80,81]. It is well established and commonly used for modeling drug release from matrix systems [81,85,86]. The model is based on a square root of a time-dependent process of Fickian diffusion.…”

Section: Resultsmentioning

confidence: 99%

Controlled Drug Delivery From Composites of Nanostructured Porous Silicon and Poly( L -Lactide)

et al. 2012

View full text Add to dashboard Cite

Aims: Porous silicon (pSi) and poly(L-lactide) (PLLA) both display good biocompatibility and tunable degradation behavior, suggesting that composites of both materials are suitable candidates as biomaterials for localized drug delivery into the human body. The combination of a pliable and soft polymeric material with a hard inorganic porous material of high drug loading capacity may engender improved control over degradation and drug release profiles and be beneficial for the preparation of advanced drug delivery devices and biodegradable implants or scaffolds. Materials & methods: In this work, three different pSi and PLLA composite formats were prepared. The first format involved grafting PLLA from pSi films via surface-initiated ring-opening polymerization (pSi–PLLA [grafted]). The second format involved spin coating a PLLA solution onto oxidized pSi films (pSi–PLLA [spin-coated]) and the third format consisted of a melt-cast PLLA monolith containing dispersed pSi microparticles (pSi–PLLA [monoliths]). The surface characterization of these composites was performed via infrared spectroscopy, scanning electron microscopy, atomic force microscopy and water contact angle measurements. The composite materials were loaded with a model cytotoxic drug, camptothecin (CPT). Drug release from the composites was monitored via fluorimetry and the release profiles of CPT showed distinct characteristics for each of the composites studied. Results: In some cases, controlled CPT release was observed for more than 5 days. The PLLA spin coat on pSi and the PLLA monolith containing pSi microparticles both released a CPT payload in accordance with the Higuchi and Ritger–Peppas release models. Composite materials were also brought into contact with human lens epithelial cells to determine the extent of cytotoxicity. Conclusion: We observed that all the CPT containing materials were highly efficient at releasing bioactive CPT, based on the cytotoxicity data. Original submitted 16 December 2010; Revised submitted 29 September 2011; Published online 6 March 2012

show abstract

Section: Resultsmentioning

confidence: 99%

Controlled Drug Delivery From Composites of Nanostructured Porous Silicon and Poly( L -Lactide)

et al. 2012

View full text Add to dashboard Cite

show abstract

“…At the beginning it was thought to be applicable to planar systems, and then it was extended to include various geometries and porous matrices (Desai et al, 1965;Higuchi, 1963;Lapidus & Lordi, 1966). In his first contribution Higuchi imagined the drug release as being modelled by the release of a cytotoxic agent from a thin ointment base, according to the following conditions:…”

Section: Resultsmentioning

confidence: 99%

Maghemite Functionalization for Antitumor Drug Vehiculization

2012

View full text Add to dashboard Cite

In this paper we describe the preparation and characterization of magnetic nanocomposites designed for applications in targeted drug delivery. Combining superparamagnetic behavior with proper surface functionalization in a single entity makes it possible to have altogether controlled location and drug loading, and release capabilities. The colloidal vehicles consist of maghemite (γ-Fe2O3) cores surrounded by a gold shell through an intermediate silica coating. The external Au layer confers the particles a high degree of biocompatibility and reactive sites for the transported drug binding. In addition, it permits to take advantage of the strong optical resonance, making it easy to visualize the particles or even control their payload release through temperature changes. The results of the analysis of relaxivity demonstrate that these nanostructures can be used as T 2 contrast agents in magnetic resonance imaging (MRI), but the magnetic cores will be mainly useful in manipulating the particles using external magnetic fields. We describe how optical absorbance and electrokinetic data provide a followup of the progress of the nanostructure formation. Additionally, these techniques, together with confocal microscopy, are employed to demonstrate that the component nanoparticles are capable of loading significant amounts of the antitumor drug doxorubicin, very efficient in the chemotherapy of a wide range of tumors. Colon adenocarcinoma cells were used to test the in vitro release capabilities of the drug-loaded nanocomposites.

show abstract

“…The zero order model defines drug delivery systems where the release of drug is not dependent on its concentration. 41 The formulators prefer to develop drug delivery systems which release drug in a zero order manner to achieve a steady release of drug. 42 The first order kinetic explains release from carriers where the release rate is concentration-dependent.…”

Section: In Vitro Drug Release Studymentioning

confidence: 99%

“…42 The first order kinetic explains release from carriers where the release rate is concentration-dependent. 41 Drug release in the Higuchi model is directly related to a square root of time based on the Fickian diffusion. 43 The Hixson-Crowell cube root equation explains the changes of drug release by change in surface area and diameter of the particles with time and is mostly used in the case of drug carriers which dissolute or erode over time.…”

Section: In Vitro Drug Release Studymentioning

confidence: 99%

Enhanced in Vitro Anti-Tumor Activity of 5-Azacytidine by Entrapment into Solid Lipid Nanoparticles

Jahanfar¹,

Hasani²,

Shanebandi³

et al. 2016

Adv Pharm Bull

View full text Add to dashboard Cite

Investigation of Factors Influencing Release of Solid Drug Dispersed in Inert Matrices

Cited by 206 publications

References 2 publications

Controlled Drug Delivery From Composites of Nanostructured Porous Silicon and Poly( L -Lactide)

Controlled Drug Delivery From Composites of Nanostructured Porous Silicon and Poly( L -Lactide)

Maghemite Functionalization for Antitumor Drug Vehiculization

Enhanced in Vitro Anti-Tumor Activity of 5-Azacytidine by Entrapment into Solid Lipid Nanoparticles

Contact Info

Product

Resources

About