Investigation of endocannabinoid modulation of conditioned responding evoked by a nicotine CS and the Pavlovian stimulus effects of CP 55,940 in adult male rats

Murray, Jennifer E.; Wells, Nicole R.; Lyford, George D.; Bevins, Rick A.

doi:10.1007/s00213-009-1572-x

Cited by 10 publications

(12 citation statements)

References 49 publications

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“…A similar result was found by Polewan et al (2013) using a 0.4 mg/kg training dose. As in previous studies, stimulus control over conditioned responding was dose-dependent; higher doses of nicotine evoked increased goal-tracking relative to the lower doses (Besheer et al , 2004; Murray et al , 2007a, b; Murray et al , 2009c; Reichel et al , 2007; Reichel et al , 2010; Struthers et al , 2009). Further, mecamylamine dose-dependently blocked goal-tracking evoked by 0.2 and 0.1 mg/kg nicotine; as mecamylamine dose increased, goal-tracking decreased.…”

Section: Discussionsupporting

confidence: 68%

Interoceptive conditioning in rats: Effects of using a single training dose or a set of 5 different doses of nicotine

Pittenger

Bevins²

2013

Pharmacology Biochemistry and Behavior

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Interoceptive conditioning contributes to the tenacity of nicotine dependence. Previous research investigating nicotine as an interoceptive stimulus has typically employed administration of a single training dose of nicotine over an extended time. This approach has allowed for careful study of the nicotine stimulus. In humans, the nicotine stimulus is unlikely to be fixed across learning episodes. Thus, from a translational perspective, systematic variation of nicotine dose in training might better approximate interoceptive conditioning in humans. Notably, training with a class or set of discrete exteroceptive stimuli (e.g., different pictures of cars) produces interesting behavioral differences relative to training with a single stimulus. The present study sought to determine whether similar differences would occur if a set of nicotine stimuli were used in place of a single dose. To investigate this question, one group of male Sprague-Dawley rats was trained on a discriminated goal-tracking task with a set of nicotine doses (0.05, 0.125, 0.2, 0.275, and 0.35 mg/kg). A second group received the standard protocol of training with a single nicotine dose (0.2 mg/kg). On each nicotine session, there was intermittent access to liquid sucrose (26%) in a conditioning chamber. On intermixed saline sessions, sucrose was withheld. We examined acquisition, subsequent extinction, transfer of extinction, nicotine generalization, and mecamylamine blockade. Both groups reliably discriminated between nicotine and saline sessions, were sensitive to non-reinforcement, displayed transfer of extinction, demonstrated dose-dependent nicotine generalization, and responding was blocked by mecamylamine. There were no significant differences between the two groups. The unique nature of an interoceptive pharmacological stimulus and the challenges posed for studying the impact of training with a set of interoceptive stimuli are discussed.

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Section: Discussionsupporting

confidence: 68%

Interoceptive conditioning in rats: Effects of using a single training dose or a set of 5 different doses of nicotine

Pittenger

Bevins²

2013

Pharmacology Biochemistry and Behavior

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“…As in our previous reports, rats in both experiments readily learned to goal-track when administered nicotine (Murray et al , 2009c; Struthers et al , 2009; Wilkinson et al , 2010). Following discrimination training, we examined the effects of early extinction with nornicotine or varenicline.…”

Section: Discussionsupporting

confidence: 66%

The effect of switching pharmacological intervention during extinction on nicotine-evoked conditioned responding in rats

et al. 2015

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Rationale Pharmacotherapies are often utilized to aid in smoking cessation and switching medication when treating nicotine dependence has become more commonplace. Although common, little is known about the impact of the initial therapeutic on the effects of the subsequent therapeutic. Objectives To begin to fill this gap in our understanding, this project determined how switching compounds that share stimulus elements with nicotine during extinction altered extinction responding and generalization of this extinction back to nicotine. Methods Rats were trained in a discriminated goal-tracking task where nicotine administration was followed by intermittent sucrose access; sucrose was withheld following saline administration. In Experiment 1, nornicotine supplanted nicotine in extinction sessions 1-3 and then a switch to varenicline on extinction sessions 4-6 was examined. In Experiment 2, the reverse was investigated; varenicline to start extinction and then a switch to nornicotine. Generalization of extinction back to the nicotine stimulus was then assessed by generating a cumulative dose-effect curve. Results Generalization of extinction back to the training nicotine stimulus was greater if nornicotine had been received at any point in extinction compared to only receiving varenicline. Whereas extinction with varenicline alone showed more generalization to lower doses of nicotine. Conclusions A switch in cessation pharmacotherapy during extinction did not impede or enhance generalization back to the nicotine training stimulus. The nornicotine stimulus appears to share more stimulus overlap with the 0.4 mg/kg nicotine stimulus and varenicline may share more overlap with lower nicotine doses.

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“…Several studies have shown that, when given to rats trained to detect the effects of nicotine, cannabinoid ligands do not have nicotine-like discriminative effects, nor do they alter the discriminative effects of nicotine when administered prior to nicotine [81,87,104]. However, opposite results have been obtained by Murray et al [105], who investigated endocannabinoid system involvement in the interoceptive effects of nicotine by using a Pavlovian discrimination procedure that differs from the drug-discrimination procedure described above. In this procedure the intermittent delivery of water occurred only during sessions when rats received nicotine; no operant response was required to produce the water, but the number of times the rat placed its head into the water dipper was measured.…”

Section: Cb 1 Receptors and Nicotine's Subjective Effectsmentioning

confidence: 87%

Cannabinoid-Nicotine Interactions

Auber

Justinová

Scherma

et al. 2015

Cannabinoid Modulation of Emotion, Memory, and Motivation

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Although nicotine and delta-9-tetrahydrocannabinol (THC), the main psychoactive ingredients in tobacco and cannabis, bind to different receptors in the brain, they have several features in common. Each of these drugs is typically selfadministered by smoking, and this behavior is maintained by rewarding effects that are mediated by brain circuitry that at least partially overlaps between the drugs. Each tends to be used chronically, leading to dependence and addiction in many users. Perhaps most importantly, the nicotinic and cannabinergic systems appear to interact in such a way that modulating one system can enhance or counteract effects of the other system. Therefore, studying cannabinoid-nicotine interactions could potentially lead to new treatments for addiction. This chapter considers such interactions, focusing on recent preclinical work that suggests manipulating the cannabinoid system can counteract the addictive effects of nicotine that manipulating the nicotinic system can counteract the addictive effects of cannabis, and that prior or concurrent use of cannabis has the detrimental effect of increasing the addictive effects of nicotine. Interactive effects of these systems on anxiety and memory are also considered, although these have been studied less than addiction-related effects.

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Investigation of endocannabinoid modulation of conditioned responding evoked by a nicotine CS and the Pavlovian stimulus effects of CP 55,940 in adult male rats

Cited by 10 publications

References 49 publications

Interoceptive conditioning in rats: Effects of using a single training dose or a set of 5 different doses of nicotine

Interoceptive conditioning in rats: Effects of using a single training dose or a set of 5 different doses of nicotine

The effect of switching pharmacological intervention during extinction on nicotine-evoked conditioned responding in rats

Cannabinoid-Nicotine Interactions

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