Investigation of efflux pump genes in isoniazid resistant Mycobacterium tuberculosis isolates

Kaya, Hamide; Ersoy, Leyla; Ülger, Mahmut; Bozok, Taylan; Aslan, Gönül

doi:10.1016/j.ijmmb.2023.100428

Cited by 1 publication

(1 citation statement)

References 14 publications

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“…Tuberculosis has also become a major global health problem. Cases of extensively drug-resistant tuberculosis (XDR-TB) have been reported in over 100 countries around the world ( Kanvatirth et al, 2019 ; Kaya et al, 2023 ).…”

Section: Introductionmentioning

confidence: 99%

Improving the treatment of bacterial infections caused by multidrug-resistant bacteria through drug repositioning

Glajzner,

Bernat,

Jasińska-Stroschein

2024

Front. Pharmacol.

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Drug repurposing (repositioning) is a dynamically-developing area in the search for effective therapy of infectious diseases. Repositioning existing drugs with a well-known pharmacological and toxicological profile is an attractive method for quickly discovering new therapeutic indications. The off-label use of drugs for infectious diseases requires much less capital and time, and can hasten progress in the development of new antimicrobial drugs, including antibiotics. The use of drug repositioning in searching for new therapeutic options has brought promising results for many viral infectious diseases, such as Ebola, ZIKA, Dengue, and HCV. This review describes the most favorable results for repositioned drugs for the treatment of bacterial infections. It comprises publications from various databases including PubMed and Web of Science published from 2015 to 2023. The following search keywords/strings were used: drug repositioning and/or repurposing and/or antibacterial activity and/or infectious diseases. Treatment options for infections caused by multidrug-resistant bacteria were taken into account, including methicillin-resistant staphylococci, multidrug-resistant Mycobacterium tuberculosis, or carbapenem-resistant bacteria from the Enterobacteriaceae family. It analyses the safety profiles of the included drugs and their synergistic combinations with antibiotics and discusses the potential of antibacterial drugs with antiparasitic, anticancer, antipsychotic effects, and those used in metabolic diseases. Drug repositioning may be an effective response to public health threats related to the spread of multidrug-resistant bacterial strains and the growing antibiotic resistance of microorganisms.

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Section: Introductionmentioning

confidence: 99%