Investigation of early effects of combination of mild aerobic exercise and angiotensin‐II type‐I receptor blocker losartan on aortic function in a mouse model of Marfan Syndrome.
Abstract:Marfan syndrome (MFS) is a connective tissue disorder that causes complications throughout the body. However, the cardiovascular effects of MFS, specifically aortic aneurysms, are the leading cause of morbidity and mortality in patients. Both the transforming growth factor beta (TGF‐β) and angiotensin II type I receptor (AT1R) signaling pathways are known to contribute to the progression of MFS aneurysms. Recently, our laboratory reported that low‐intensity mild exercise could improve aortic function and struc… Show more
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