Investigation of dynamic deformation of the midbrain in rear-end collision using human brain FE model

Atsumi, Noritoshi; Iwamoto, Masami; Nakahira, Yuko; Asano, Yoshitaka; Shinoda, Jun

doi:10.1080/10255842.2020.1795142

Cited by 2 publications

(1 citation statement)

References 19 publications

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“…This result is consistent with postmortem histopathological studies that have reported that the brainstem, particularly the upper brainstem, is one of the major locations of axonal injury 2,[8][9][10][11] . Indeed, a biomechanical model has demonstrated that the greatest strain effects occur in the brainstem, particularly in the upper brainstem 30,31 . The association between acute-phase consciousness disorder and brainstem injury has been explored previously in patients with TBI.…”

Section: Discussionmentioning

confidence: 99%

A model for estimating the brainstem volume in normal healthy individuals and its application to diffuse axonal injury patients

Fujimoto

Ubukata

Sugihara

et al. 2023

Sci Rep

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Diffuse axonal injury (DAI) is a subtype of traumatic brain injury that causes acute-phase consciousness disorders and widespread chronic-phase brain atrophy. Considering the importance of brainstem damage in DAI, a valid method for evaluating brainstem volume is required. We obtained volume measurements from 182 healthy adults by analyzing T1-weighted magnetic resonance images, and created an age-/sex-/intracranial volume-based quantitative model to estimate the normal healthy volume of the brainstem and cerebrum. We then applied this model to the volume measurements of 22 DAI patients, most of whom were in the long-term chronic phase and had no gross focal injury, to estimate the percentage difference in volume from the expected normal healthy volume in different brain regions, and investigated its association with the duration of posttraumatic amnesia (which is an early marker of injury severity). The average loss of the whole brainstem was 13.9%. Moreover, the percentage loss of the whole brainstem, and particularly of the pons and midbrain, was significantly negatively correlated with the duration of posttraumatic amnesia. Our findings suggest that injury severity, as denoted by the duration of posttraumatic amnesia, is among the factors affecting the chronic-phase brainstem volume in patients with DAI.

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