BEvery once in a while, a new technology, an old problem, and a big idea turn into an innovation^-Dean Kamen Radiation therapy is a leading branch in cancer management these days. This branch is highly influenced by technical development and innovation in radiation treatment delivering and diagnosing equipment with high accuracy and precision. Radiation treatment is an effective, personalized cancer treatment that has benefited from technological advancements. Given that these advances have played a central role in the success of radiation therapy as a major component of comprehensive cancer care [1,2].The purpose of this special issue is to provide a platform to discuss new ideas of emerging technology for the field and to recognize areas for greater research investment. Expert clinicians and scientists discussed innovative technology in radiation oncology, in particular as to how these technologies are being developed and translated to clinical practice in the face of future challenges and opportunities.In this issue we have included technologies encompassed topics in functional imaging, treatment devices, nanotechnology, and information technology (IT), radiation dosimetry. The technical, quality and safety performance of these technologies is also considered. A major theme of the issue was the growing importance of innovation in the domain of process automation, oncology informatics and better diagnosis. This issue includes five papers which were presented during AOCMP-AMPICON2017 in Jaipur, India. The selection criteria of papers is on the basis of innovative original ideas, economical technology development, automation, radiation dosimetry in field of radio-diagnosis and radiotherapy.In the paper titled BDevelopment of a CMOS-based Optical Computed Tomography System (CMOS-OCT) for 3D Radiotherapy Dosimetry^Nurul Farah Rosli et al. have shown characteristics of in-house developed 3D imaging system named BOptical Computed Tomography (OCT) for ensuring radiotherapy dose delivered to PRESAGE™ dosimeters. It reconstructs dose distributions delivered to the radiochromic PRESAGE™ that changes its colour when irradiated. The results show that the system is capable of capturing the projection images of a 3D translucent object with good linearity and uniformity.In the paper titled BAn inexpensive method of Small Photon Field Dosimetry with EBT3 Radiochromic Film nkurMourya et al. have developed a MATLAB program to use EBT3 Radiochromic films as a dosimeter for small field dosimetry. Small field dosimetry is complicated due to electron disequilibrium, steep dose gradient and perturbation due to different densities of the detector and the medium [3]. They have demonstrated that due to excellent spatial resolution EBT3 Radio-chromic films can be used as economical small field dosimeter with high sensitivity, reproducibility and ease of use.In the paper titled BDual-energy high-count-rate X-ray computed tomography scanner using a cerium-doped yttrium aluminum perovskite crystal and a smallphotomultiplier tube^Tsukuru S...