Investigation of Drug Nanoparticle Formation by Co-grinding with Cyclodextrins: Studies for Indomethacin, Furosemide and Naproxen

Preparation of Drug Nanoparticles by Co-grinding with Cyclodextrin: Formation Mechanism and Factors Affecting Nanoparticle Formation

“…However, for g-CD, the recovery of the ground mixture of indomethacin and intact g-CD (hydrate form) showed much higher recovery than the ground mixture prepared with added moisture, implying that the position of water molecules in g-CD might be important for nanoparticle formation. 11) This subject would although remain to be further investigation.…”

“…On the other hand, CD could not interact with drug particle surface when co-grinding was performed in dry conditions, and consequently resulted in an aggregation of particles. The recrystallization of CD would occur during co-grinding in high moisture content, 11) which resulted in less CD-drug interaction and low nanoparticle formation. The suitable water content was necessary for the establishment of drug-CD interaction as well as for the formation of the CD matrix.…”

“…[10][11][12] We also found that moisture content in the co-grinding process was an important factor and a suitable moisture condition during co-grinding was indispensable for nanoparticle formation.…”

“…In the past few years, there are many publications focusing on the preparation of drug particles at the nanometer level by co-grinding with additives. [7][8][9][10][11][12][13][14] In previous studies, we have reported the formation of pranlukast nanoparticle with mean particle size around 200 nm by co-grinding with CDs.10) Co-grinding with CDs could be applied as a nanoparticle preparation method for various kinds of poorly water-soluble drugs. [10][11][12] We also found that moisture content in the co-grinding process was an important factor and a suitable moisture condition during co-grinding was indispensable for nanoparticle formation.…”

“…In the past few years, there are many publications focusing on the preparation of drug particles at the nanometer level by co-grinding with additives. [7][8][9][10][11][12][13][14] In previous studies, we have reported the formation of pranlukast nanoparticle with mean particle size around 200 nm by co-grinding with CDs.…”