Investigation of Drug Eluting Stents Performance Through in silico Modeling

Loukas, Vasileios S.; Pleouras, Dimitrios S.; Karanasiou, Georgia S.; Kyriakidis, Savvas; Sakellarios, Antonis I.; Semertzioglou, Arsen; Michalis, Lambros K.; Fotiadis, Dimitrios I.

doi:10.1007/978-3-030-64610-3_80

Cited by 4 publications

(3 citation statements)

References 20 publications

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“…With the application and invention of coronary stents, a dramatic decrease in bypass surgeries was reported. Drug-eluting stents (DESs) were developed to replace conventionally used bare metal stents (BMSs), as they caused complications such as reblockage of vessels, called in-stent restenosis. , After stent implantation, approximately 20–30% of patients experienced in-stent restenosis . This post-implant complication is due to vascular smooth cell proliferation, migration, and growth of the arterial inner wall because of the insufficient biocompatibility of stent material .…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Fine-Tuning the Nanostructured Titanium Oxide Surface for Selective Biological Response

Rawat,

Benčina,

Paul

et al. 2023

ACS Appl. Bio Mater.

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Cardiovascular diseases are a pre-eminent global cause of mortality in the modern world. Typically, surgical intervention with implantable medical devices such as cardiovascular stents is deployed to reinstate unobstructed blood flow. Unfortunately, existing stent materials frequently induce restenosis and thrombosis, necessitating the development of superior biomaterials. These biomaterials should inhibit platelet adhesion (mitigating stent-induced thrombosis) and smooth muscle cell proliferation (minimizing restenosis) while enhancing endothelial cell proliferation at the same time. To optimize the surface properties of Ti 6 Al 4 V medical implants, we investigated two surface treatment procedures: gaseous plasma treatment and hydrothermal treatment. We analyzed these modified surfaces through scanning electron microscopy (SEM), water contact angle analysis (WCA), X-ray photoelectron spectroscopy (XPS), and X-ray diffraction (XRD) analysis. Additionally, we assessed in vitro biological responses, including platelet adhesion and activation, as well as endothelial and smooth muscle cell proliferation. Herein, we report the influence of pre/post oxygen plasma treatment on titanium oxide layer formation via a hydrothermal technique. Our results indicate that alterations in the titanium oxide layer and surface nanotopography significantly influence cell interactions. This work offers promising insights into designing multifunctional biomaterial surfaces that selectively promote specific cell types’ proliferation—which is a crucial advancement in next-generation vascular implants.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Fine-Tuning the Nanostructured Titanium Oxide Surface for Selective Biological Response

Rawat,

Benčina,

Paul

et al. 2023

ACS Appl. Bio Mater.

View full text Add to dashboard Cite

show abstract

“…For patients affected by CVD, the implantation of a drug-eluting stent (DES) is currently the most commonly accepted treatment [ 6 ]. DESs have demonstrated superiority to bare-metal stents (BMSs) concerning reduced neointimal hyperplasia (restenosis) [ 7 ], however, delayed endothelization and an increased risk of late stent thrombosis was detected with the first generation of these devices [ 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Bio-Performance of Hydrothermally and Plasma-Treated Titanium: The New Generation of Vascular Stents

Benčina

Rawat

Lakota

et al. 2021

IJMS

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The research presented herein follows an urgent global need for the development of novel surface engineering techniques that would allow the fabrication of next-generation cardiovascular stents, which would drastically reduce cardiovascular diseases (CVD). The combination of hydrothermal treatment (HT) and treatment with highly reactive oxygen plasma (P) allowed for the formation of an oxygen-rich nanostructured surface. The morphology, surface roughness, chemical composition and wettability of the newly prepared oxide layer on the Ti substrate were characterized by scanning electron microscopy (SEM) with energy-dispersive X-ray analysis (EDX), atomic force microscopy (AFM), X-ray photoelectron spectroscopy (XPS) and water contact angle (WCA) analysis. The alteration of surface characteristics influenced the material’s bio-performance; platelet aggregation and activation was reduced on surfaces treated by hydrothermal treatment, as well as after plasma treatment. Moreover, it was shown that surfaces treated by both treatment procedures (HT and P) promoted the adhesion and proliferation of vascular endothelial cells, while at the same time inhibiting the adhesion and proliferation of vascular smooth muscle cells. The combination of both techniques presents a novel approach for the fabrication of vascular implants, with superior characteristics.

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Investigation of the drug release time from the biodegrading coating of an everolimus eluting stent

Pleouras

Karanasiou

Loukas

et al. 2021

2021 43rd Annual International Conference of the IEEE Engineering in Medicine &Amp; Biology Society (EMBC)

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Investigation of Drug Eluting Stents Performance Through in silico Modeling

Cited by 4 publications

References 20 publications

Fine-Tuning the Nanostructured Titanium Oxide Surface for Selective Biological Response

Fine-Tuning the Nanostructured Titanium Oxide Surface for Selective Biological Response

Bio-Performance of Hydrothermally and Plasma-Treated Titanium: The New Generation of Vascular Stents

Investigation of the drug release time from the biodegrading coating of an everolimus eluting stent

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