Investigation of dogs as a reservoir of Penicillium marneffei in northern Thailand

Chaiwun, Benjaporn; Vanittanakom, Nongnuch; Jiviriyawat, Yupa; Rojanasthien, S.; Thorner, Paul

doi:10.1016/j.ijid.2010.12.001

Cited by 32 publications

(15 citation statements)

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“…In this study, HIV-infected patients came from different regions in China, and the findings revealed that other fungal infection[11] and Penicillium Marneffei infection[12] were more common in Southern and Southwestern China, where the ecological conditions and humid climate were similar to that of Southeast Asia. But these fungal infections were rarely found in the northwestern China due to dry climate.…”

Section: Discussionmentioning

confidence: 99%

Spectrums of Opportunistic Infections and Malignancies in HIV-Infected Patients in Tertiary Care Hospital, China

Xiao

Gao

et al. 2013

PLoS ONE

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BackgroundHIV-related opportunistic infections (OIs) and malignancies continued to cause morbidity and mortality in Chinese HIV-infected individuals. The objective for this study is to elucidate the prevalence and spectrums of OIs and malignancies in HIV-infected patients in the Beijing Ditan Hospital.MethodsThe evaluation of the prevalence and spectrums of OIs and malignancies was conducted by using the clinical data of 834 HIV-infected patients admitted in the Beijing Ditan hospital from January 1, 2009, to November 30, 2012.ResultsThe prevalence and spectrums of OIs and malignancies varied contingent on geographic region, transmission routes, and CD4 levels. We found that tuberculosis was most common OI and prevalence was 32.5%, followed by candidiasis(29.3%), Pneumocystis pneumonia(PCP)(22.4%), cytomegalovirus(CMV) infection(21.7%), other fungal infections(16.2%), mycobacterium avium complex(MAC)(11.3%), cryptococcosis(8.0%), progressive multifocal leukoencephalopathy(PML)(4.4%), Cerebral Toxoplasmosis(3.5%) and Penicillium marneffei infection(1.4%); while Lymphoma(2.9%), Kaposi’s sarcoma(0.8%) and cervix carcinoma(0.3%) were emerged as common AIDS-defining malignancies. Pulmonary OI infections were the most prevalent morbidity and mortality in patients in the AIDS stage including pulmonary tuberculosis (26.6%) and PCP (22.4%). CMV infection(21.7%) was most common viral infection; Fungal OIs were one of most prevalent morbidity in patients in the AIDS stage, including oral candidiasis (29.3%), other fungal infection (16.2%), Cryptococcosis (8.0%) and Penicillium marneffei infection (1.4%). We found the low prevalence of AIDS-defining illnesses in central neural system in this study, including progressive multifocal leukoencephalopathy (4.4%), cerebral toxoplasmosis (3.5%), tuberculosis meningitis (3.2%), cryptococcal meningitis (2.4%) and CMV encephalitis (1.1%). In-hospital mortality rate was 4.3 per 100 person-years due to severe OIs, malignancies, and medical cost constraints.ConclusionsThe prevalence and spectrums of OIs, malignancies and co-infections were discussed in this study. It would help increase the awareness for physicians to make a diagnosis and empirical treatment sooner and plan good management strategies, especially in resource limited regions.

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Section: Discussionmentioning

confidence: 99%

Spectrums of Opportunistic Infections and Malignancies in HIV-Infected Patients in Tertiary Care Hospital, China

Xiao

Gao

et al. 2013

PLoS ONE

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“…Fungal opportunistic infections were one of the most frequent causes of cervical lymphadenopathy in HIV/ AIDS patients, including cryptococcosis (1.5%), Talaromyces marneffei (1.5%), and other fungi (0.4%).With different climatic and social-economic conditions, the types and frequencies of opportunistic infections change from region to region [21]. Talaromyces marneffei was reported to be more common in Southern and Southwestern China, where the humid climate and ecological conditions were almost the same as that of Southeast Asia [22].…”

Section: Discussionmentioning

confidence: 99%

Analysis of the causes of cervical lymphadenopathy using fine-needle aspiration cytology combining cell block in Chinese patients with and without HIV infection

et al. 2020

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Background: Cervical lymphadenopathy refers to a frequently observed clinical presentation in numerous pathological conditions. A wide spectrum of diseases can cause cervical lymphadenopathy, irrespective of the fact that the patients are infected with HIV or not. The present study focuses on validating whether the causes of cervical lymphadenopathy differ significantly in HIV and non-HIV patients by using fine-needle aspiration cytology (FNAC) combining cell block. Methods: A total of 589 patients with cervical lymphadenopathy were recruited in the FNA clinic. The samples were obtained by an auto-vacuumed syringe that benefited the sampling more materials. The cytological smears were prepared by Hematoxylin and Eosin (HE), Periodic Acid Schiff (PAS), Gomori's methenamine silver (GMS) and acid-fast staining. Cell blocks were made if required, and immunohistochemistry stain was performed on the cell block section.

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“…19 Regio lain yang beberapa kali dipakai dalam identifikasi molekular T. marneffei adalah regio 18S rDNA, D2 (bagian dari 28S rDNA), dan MP1. 10,[30][31][32] Identifikasi molekular T. marneffei telah terbukti berhasil dilakukan pada kultur jamur berusia minimal tujuh hari. 19 Isolasi DNA dari koloni jamur akan menjamin keberhasilan PCR karena jumlah jamur/DNA lebih banyak setelah koloni jamur tumbuh pada medium kultur.…”

Section: Pemeriksaan Molekularunclassified

Talaromikosis Marneffei

Surja

Adawiyah

Wahyuningsih³

2019

JIK

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Talaromycosis marneffei is a mycotic disease caused by Talaromyces marneffei which primarily infectimmunocompromised patient. This disease is endemic in Southeast Asia, and Indonesia consider as endemic area dueto a case of tourist who got the infection after visiting Indonesia. Diagnosis was made based on clinical suspicion withlaboratory confirmation. Clinical manifestations are not specific, such as fever, anemia, weight loss, lymphadenopathy,hepatomegaly, splenomegaly, respiratory disorder, and cutaneous manifestation. Histopathology and culture are themost common examination performed for diagnosis. In histopathology examination, fungi appear as fission arthroconidiacells which shape round to oval, with cross wall formation inside or outside macrophage and histiocyte. Thermaldimorphism characteristic can be observed in fungal culture. Fungi grows as mold at 25oC-30oC and as yeast at 37oC.Definitive identification of T. marneffei was done by molecular examination using primers derived from ITS region asprimary marker and beta tubulin region as secondary marker. Talaromyces marneffei is sapronosis, that transmitted viainhalation of conidia from environment.

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Investigation of dogs as a reservoir of Penicillium marneffei in northern Thailand

Abstract: Our results suggest that dogs might be an animal reservoir for P. marneffei in northern Thailand. This observation should be confirmed by additional studies.

Cited by 32 publications

References 28 publications

Spectrums of Opportunistic Infections and Malignancies in HIV-Infected Patients in Tertiary Care Hospital, China

Spectrums of Opportunistic Infections and Malignancies in HIV-Infected Patients in Tertiary Care Hospital, China

Analysis of the causes of cervical lymphadenopathy using fine-needle aspiration cytology combining cell block in Chinese patients with and without HIV infection

Talaromikosis Marneffei

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