Investigation of Displacement of Intracranial Electrode Induced by Focused Ultrasound Stimulation

Kim, Min Gon; Yu, Kai; Niu, Xiaodan

doi:10.1109/tim.2021.3125978

Cited by 6 publications

(5 citation statements)

References 65 publications

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“…Another concern raised in ultrasound stimulation specifically when recording from an electrode is whether the electrode tip itself is vibrating and causing local effects through its movement. Previous studies have found that electrode displacement becomes significant past the threshold of a pressure of 131kPA, which our stimulation paradigm does not reach (M. G. Kim et al, 2021).…”

Section: Discussioncontrasting

confidence: 68%

Ultrasound Neuromodulation and Correlation Change in the Rat Somatosensory Cortex

Ramachandran

Niu

et al. 2022

Preprint

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Transcranial focused ultrasound (tFUS) is a neuromodulation technique which has been the focus of increasing interest for noninvasive brain stimulation with high spatial specificity. Its ability to excite and inhibit neural circuits as well as to modulate perception and behavior has been demonstrated, however, we currently lack understanding of how tFUS modulates the ways neurons interact with each other. This understanding would help explain tFUS's mechanism of high-level neuromodulation and allow future development of therapies for neurological disorders. In this study we investigate how tFUS modulates neural interaction and response to peripheral electrical limb stimulation through intracranial multi-electrode recordings in the rat somatosensory cortex. We deliver ultrasound in a pulsed pattern to attempt to induce frequency dependent plasticity in a manner similar to that found following electrical stimulation. We show that neural firing in response to peripheral electrical stimulation is increased after ultrasound stimulation at all frequencies, showing tFUS induced excitation in individual neurons in vivo. We demonstrate tFUS frequency dependent pairwise correlation changes between neurons, with both potentiation and depression observed at different frequencies. These results extend previous research showing tFUS to be capable of inducing synaptic depression and demonstrate its ability to modulate network dynamics as a whole.

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Section: Discussioncontrasting

confidence: 68%

Ultrasound Neuromodulation and Correlation Change in the Rat Somatosensory Cortex

Ramachandran

Niu

et al. 2022

Preprint

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“…By recording remotely from the site of ultrasound stimulation, we were able to eliminate numerous confounding factors that exist especially in physical electrode-based electrophysiological recordings (e.g., potential electrode vibration 23 ). In this setting, delivering tFUS stimulation remotely was a rigorous way to study tFUS-induced effects in a well-defined brain network without being confounded by potential mechanical vibrations of electrodes, through either the artifacts presented in the recordings or electrode-vibration-induced neural effects.…”

Section: Discussionmentioning

confidence: 99%

Transcranial Focused Ultrasound Remotely Modulates Extrastriate Visual Cortex with Subregion Specificity

Yu,

Schmitt,

et al. 2024

Preprint

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Low-intensity transcranial focused ultrasound (tFUS) has emerged as a powerful neuromodulation tool characterized by its deep penetration and precise spatial targeting to influence neural activity. Our study directed low-intensity tFUS stimulation onto a region of prefrontal cortex (the frontal eye field, or FEF) of a rhesus macaque to examine its impact on a remote site, the extrastriate visual cortex (area V4). This pair of cortical regions form a top-down modulatory circuit that has been studied extensively with electrical microstimulation. To measure the impact of tFUS stimulation, we recorded local field potentials (LFPs) and multi-unit spiking activities from a multi-electrode array implanted in the visual cortex. To deliver tFUS stimulation, we leveraged a customized 128-element random array ultrasound transducer with improved spatial targeting. We observed that tFUS stimulation in FEF produced modulation of V4 neuronal activity, either through enhancement or suppression, dependent on the pulse repetition frequency of the tFUS stimulation. Electronically steering the transcranial ultrasound focus through the targeted FEF cortical region produced changes in the level of modulation, indicating that the tFUS stimulation was spatially targeted within FEF. Modulation of V4 activity was confined to specific frequency bands, and this modulation was dependent on the presence or absence of a visual stimulus during tFUS stimulation. A control study targeting the insula produced no effect, emphasizing the region-specific nature of tFUS neuromodulation. Our findings shed light on the capacity of tFUS to modulate specific neural pathways and provide a comprehensive understanding of its potential applications for neuromodulation within brain networks.

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“…This study was limited spatially in its ability to directly measure neuronal activity due to the setup of the LIFU device. While electrophysiological recording is difficult in FUS studies due to mechanical displacements of electrodes causing electrical artifacts (Manuel et al 2020, Kim et al 2021, the present study could be complimented by future work using optical readouts of neuronal activity such as Ca 2+ imaging.…”

Section: Motor Responses To Lifu and Vibrationsmentioning

confidence: 99%

“…The deposition of mechanical energy into tissue is called acoustic radiation force (ARF). FUS applies ARF to the conducting medium, as evidenced by micron-level displacements of rigid spheres in tissue-mimicking phantoms (Aglyamov et al 2007) and of microelectrode arrays in ex vivo brain tissue (Kim et al 2021) caused by FUS stimulation.…”

Section: Introductionmentioning

confidence: 99%

Investigating the impact of skull vibrations on motor responses to focused ultrasound neuromodulation in small rodents and methods to mitigate them

Hesselink,

Krasnichuk,

Benaceur

et al. 2023

Phys. Med. Biol.

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Objective: Focused ultrasound (FUS) neuromodulation non-invasively alters brain activity, likely via acoustic radiation force (ARF) with dynamics of the pulse repetition frequency (PRF). PRF impacts neuromodulation as well as indirect auditory activation, a confound linked to skull vibrations. This study aimed to minimize these vibrations, by adjusting and randomizing PRF, and determine their impact on FUS-induced motor activity. We hypothesized that: the skull would vibrate most at a specific PRF; randomizing PRF would reduce skull vibrations without affecting motor responses; and FUS would yield motor activity while actuator-induced skull vibrations would not. Approach: Three objectives were studied in parallel using C57Bl/6 mice (n = number of mice used per objective). First, skull vibration amplitude, measured as a percentage of maximum amplitude per treatment, was recorded via contact microphone over a range of PRFs to assess the PRF-dependency of skull vibrations (n = 19). Vibrations were then compared between random and fixed PRFs (n = 15). Lastly, motor responses were compared between fixed 1.5 kHz PRF FUS, random PRF FUS, air-puff stimulation, sham stimulation, and vibration induction via piezoelectric actuator (n = 30). Main Results: The study found amplitude peaked at 1.51 kHz (88.1 ± 11.5%), significantly higher than at 0.54 kHz (75.5 ± 15.1%; p = 0.0149). Random PRF reduced amplitude by 4.2% (p = 0.0181). Motor response rates to actuator-induced skull vibrations at the PRF (5.73 ± 6.96%) and its third harmonic (22.9 ± 22.7%) were not significantly different than sham (14.1 ± 11.6%), but lower than FUS (70.2 ± 16.3%; p < 0.0001). Significance: Based on these results, PRF near 0.5 kHz may best avoid skull vibrations, while random PRF could be utilized to slightly reduce vibration amplitude. The results also suggested that skull vibrations likely do not significantly impact motor responses to FUS neuromodulation.

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Investigation of Displacement of Intracranial Electrode Induced by Focused Ultrasound Stimulation

Cited by 6 publications

References 65 publications

Ultrasound Neuromodulation and Correlation Change in the Rat Somatosensory Cortex

Ultrasound Neuromodulation and Correlation Change in the Rat Somatosensory Cortex

Transcranial Focused Ultrasound Remotely Modulates Extrastriate Visual Cortex with Subregion Specificity

Investigating the impact of skull vibrations on motor responses to focused ultrasound neuromodulation in small rodents and methods to mitigate them

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