Investigation of diseases through red blood cells' shape using photoacoustic response technique

Biswas, Deblina; Gorey, Abhijeet; Chen, Goerge C. K.; Sharma, Norman; Vasudevan, Srivathsan

doi:10.1117/12.2079185

Cited by 7 publications

(5 citation statements)

References 7 publications

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“…These features of PA time domain signal indicate very important properties of the sample. For example, PA signal amplitude is related to a sample's optical absorption and laser energy irradiated onto the sample, delay provides information about the position of the absorber, width of the signal represents the size of the absorber and relaxation time depicts the elastic property of the sample [29,30]. Therefore, PA signal consists of critical information about the sample.…”

Section: Characteristics Of Time Domain Pa Signalmentioning

confidence: 99%

Biomedical Application of Photoacoustics: A Plethora of Opportunities

2022

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The photoacoustic (PA) technique is a non-invasive, non-ionizing hybrid technique that exploits laser irradiation for sample excitation and acquires an ultrasound signal generated due to thermoelastic expansion of the sample. Being a hybrid technique, PA possesses the inherent advantages of conventional optical (high resolution) and ultrasonic (high depth of penetration in biological tissue) techniques and eliminates some of the major limitations of these conventional techniques. Hence, PA has been employed for different biomedical applications. In this review, we first discuss the basic physics of PA. Then, we discuss different aspects of PA techniques, which includes PA imaging and also PA frequency spectral analysis. The theory of PA signal generation, detection and analysis is also detailed in this work. Later, we also discuss the major biomedical application area of PA technique.

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Section: Characteristics Of Time Domain Pa Signalmentioning

confidence: 99%

Biomedical Application of Photoacoustics: A Plethora of Opportunities

2022

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“…Blood reflects the status of internal organs and tissues throughout the body and is therefore important in detecting, monitoring, and treating many diseases. Photoacoustic signals have been applied in many blood-related studies [5], such as the observation of size and shape of red blood cells [6][7][8][9], measurement of blood glucose concentration [10,11], early malaria diagnosis [12,13], diagnosis of bacteria in the blood [14], detection of circulating tumor cells [15,16], investigation of hemoglobin oxygen and carboxyhemoglobin saturation [17,18], bilirubin monitoring [19], and pharmaceuticals monitoring [20][21][22]. In particular, light scattering by blood cells can be effectively used to assess the general state of health and catch the early signs of multiple diseases [23].…”

Section: Introductionmentioning

confidence: 99%

Photoacoustic and absorption spectroscopy imaging analysis of human blood

et al. 2023

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Photoacoustic and absorption spectroscopy imaging are safe and non-invasive molecular quantification techniques, which do not utilize ionizing radiation and allow for repeated probing of samples without them being contaminated or damaged. Here we assessed the potential of these techniques for measuring biochemical parameters. We investigated the statistical association between 31 time and frequency domain features derived from photoacoustic and absorption spectroscopy signals and 19 biochemical blood parameters. We found that photoacoustic and absorption spectroscopy imaging features are significantly correlated with 14 and 17 individual biochemical parameters, respectively. Moreover, some of the biochemical blood parameters can be accurately predicted based on photoacoustic and absorption spectroscopy imaging features by polynomial regression. In particular, the levels of uric acid and albumin can be accurately explained by a combination of photoacoustic and absorption spectroscopy imaging features (adjusted R-squared > 0.75), while creatinine levels can be accurately explained by the features of the photoacoustic system (adjusted R-squared > 0.80). We identified a number of imaging features that inform on the biochemical blood parameters and can be potentially useful in clinical diagnosis. We also demonstrated that linear and non-linear combinations of photoacoustic and absorption spectroscopy imaging features can accurately predict some of the biochemical blood parameters. These results demonstrate that photoacoustic and absorption spectroscopy imaging systems show promise for future applications in clinical practice.

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“…The sample, upon non-radiative relaxation, generates ultrasound waves which are acquired using an immersion based ultrasound sensor. The ultrasound sensor converts these pressure waves into the electrical signal (PA signal) and stored in the memory of oscilloscope for further signal processing [11]. In order to form an image a single ultrasound sensor is scanned across the sample or an array of ultrasound sensors is used, to obtain the PA signals from different locations of the sample.…”

Section: Introductionmentioning

confidence: 99%