Investigation of Dependency of Boric Acid and Lithium Metaborate Induced Yeast Toxicity on the Expressions of Antioxidative and Apoptotic Genes

Cdc73 is a major regulator of apoptosis‐inducing factor 1 expression in Saccharomyces cerevisiae via H3K36 methylation

“…While several studies report the effect of histone modifications on yeast apoptosis [32], none of them reported the impact of histone modifications on the transcriptional regulation of apoptotic genes. Considering the facts that Aif1‐mediated yeast apoptosis is caspase‐independent [33,34], its gene levels increase upon boric acid or lithium metaborate (two industrially important chemicals) treatment [35], its involvement in yeast apoptosis due to a wide array of molecules, including H 2 O 2 [6], acetic acid [6], manganese [36], an antifungal agent like caspofungin [37] and its role in fluconazole sensitivity [38], studying the AIF1 gene regulation will significantly add to the growing literature of AIF1 mediated effects on yeast cell while providing impetus to the study of the regulation of apoptosis‐related genes.…”