Investigation of Cutaneous Histamine Sensitivity in Children with Pertussis

Pieroni, Robert E.; Stevens, David L.; Stojanović, Aleksandra; Levine, Leo

doi:10.1159/000230585

Cited by 2 publications

(3 citation statements)

References 5 publications

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“…To summarize, histamine sensitization in mice in response to B. pertussis infection was first described over 50 years ago (606). Subsequently, histamine sensitization was studied by many investigators, but only five studies involving humans were carried out (269,486,501,561,574,576,618,622,625,686,701,801). In a 1948 study, Parfentjev and Goodline found that mice injected intraperitoneally with a pertussis vaccine subsequently became hypersensitive to histamine challenge; 2 mg of histamine had similar lethality in sensitized (previously vaccinated) mice as did 50 mg in unvaccinated mice (606).…”

Section: Virulence Determinantsmentioning

confidence: 99%

“…In three controlled studies in children, histamine sensitization could not be demonstrated in association with B. pertussis infection or following vaccination (269,501,618). In the most recent study, Gifford et al compared skin test sensitivity to histamine in DT-and DTP-immunized children and found no significant difference in wheal size between the two groups (269).…”

Section: Virulence Determinantsmentioning

confidence: 99%

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Molecular Pathogenesis, Epidemiology, and Clinical Manifestations of Respiratory Infections Due toBordetella pertussisand OtherBordetellaSubspecies

2005

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Bordetella respiratory infections are common in people (B. pertussis) and in animals (B. bronchiseptica). During the last two decades, much has been learned about the virulence determinants, pathogenesis, and immunity of Bordetella. Clinically, the full spectrum of disease due to B. pertussis infection is now understood, and infections in adolescents and adults are recognized as the reservoir for cyclic outbreaks of disease. DTaP vaccines, which are less reactogenic than DTP vaccines, are now in general use in many developed countries, and it is expected that the expansion of their use to adolescents and adults will have a significant impact on reducing pertussis and perhaps decrease the circulation of B. pertussis. Future studies should seek to determine the cause of the unique cough which is associated with Bordetella respiratory infections. It is also hoped that data gathered from molecular Bordetella research will lead to a new generation of DTaP vaccines which provide greater efficacy than is provided by today's vaccines

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Section: Virulence Determinantsmentioning

confidence: 99%

Section: Virulence Determinantsmentioning

confidence: 99%

Molecular Pathogenesis, Epidemiology, and Clinical Manifestations of Respiratory Infections Due toBordetella pertussisand OtherBordetellaSubspecies

2005

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“…Nevertheless there is little doubt that, during an infection with B.pertussis, PT gains access to the circulation of the patient, because lymphocytosis (absolute or relative) is a well-recognised diagnostic sign (Walker et al, 1981) in the disease and can reasonably be attributed to this toxin. Regarding HSF activity, there is a report (Sanyal, 1960), but also a denial (Pieroni et al, 1971), of histaminesensitisation in children with pertussis. From the IAP activity of PT, it might be expected that plasma insulin would be elevated in pertussis; but no supporting data have yet been published.…”

Section: Introductionmentioning

confidence: 99%

Slight hyperinsulinaemia but no hypoglycaemia in pertussis patients

Furman

Walker

Sidey

et al. 1988

Journal of Medical Microbiology

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Summary. Because of the central r61e postulated for Pertussis Toxin in the pathogenesis of whooping cough, and the well-established ability of this toxin to alter insulin and glucose levels in animal blood, a study of insulin and glucose levels in hospitalised pertussis patients and in controls was made. With blood specimens collected in heparin-fluoride anticoagulant, the geometric mean plasma-insulin level (1 3.3 pU/ml) in a series of 24 pertussis patients was slightly, but statistically significantly, higher than that (8.9pU/ml) in a series of 27 non-pertussis controls with other infectious diseases (p < 0.02). Portions of the same blood specimens collected in lithium-heparin anticoagulant yielded higher mean plasma-insulin values of 15.5 and 11.4 pU/ml respectively, with no significant difference between them (p > 0.05). Mean plasma glucose concentrations were not significantly different between the two groups, and hypoglycaemia was not detected in any pertussis patient. There were no statistically significant differences between pertussis and control children in the mean levels of plasma calcium, magnesium or phosphate.

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Investigation of Cutaneous Histamine Sensitivity in Children with Pertussis

Cited by 2 publications

References 5 publications

Molecular Pathogenesis, Epidemiology, and Clinical Manifestations of Respiratory Infections Due toBordetella pertussisand OtherBordetellaSubspecies

Molecular Pathogenesis, Epidemiology, and Clinical Manifestations of Respiratory Infections Due toBordetella pertussisand OtherBordetellaSubspecies

Slight hyperinsulinaemia but no hypoglycaemia in pertussis patients

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