Investigation of copper nanoparticles antibacterial mechanisms tested by luminescent Escherichia coli strains

Green synthesis of copper nanoparticles by Citrus medica Linn. (Idilimbu) juice and its antimicrobial activity

“…Similarly, CuNPs also interact with DNA molecules leading to its degradation by disturbing its helical structure (Kim et al 2000). In fact, the cell membrane integrity depends on its electrochemical potential, but Deryabin et al (2013) reported that CuNPs decrease the electrochemical potential of the cell membrane, which ultimately affects cell membrane integrity. It was also believed that metal nanoparticles release their respective ions and such heavy metal ions demonstrated adverse effect on bacterial cell (Cioffi et al 2005).…”

“…Accumulation of CuNPs and Cu ions on cell surface form pits in the membrane, which mainly leads to the leakage of cellular component from cell and eventually causes cell death. Another important reason proposed for the cell death due to action of CuNPs is development of oxidative stress (Deryabin et al 2013). Considering all the above possibilities here, we have proposed a schematic representation (Fig.…”

Metal Nanoparticles Reduce Bacterial Contamination of Experimental Purulent Wounds

“…The development of oxidative stress of microorganisms results from electron transfer to the molecular oxygen via copper NP, incorporated in the bacterial cell membrane; this results in ROS impairment of DNA molecules [3]. Another report [4] indicates that the antibacterial effect of copper NP is due to impairment of the barrier function of the bacterium cell membrane as a result of calcium cation leakage.…”

“…I. V. Babushkina Active formation of antibiotic resistance of microorganisms necessitates search for new alternative antibacterial drugs. Metal nanoparticles (NP) are a perspective base for creation of a new class of antibacterial agents due to their low toxicity, long action, and stimulation (in biological doses) of the functional activities of enzymatic systems [8].The antibacterial and wound-healing effects of copper and zinc NP are described [1][2][3]11]. The signifi cance of physicochemical characteristics of NP for manifestation of their antibacterial and wound-healing activities is shown [5].…”

“…The antibacterial and wound-healing effects of copper and zinc NP are described [1][2][3]11]. The signifi cance of physicochemical characteristics of NP for manifestation of their antibacterial and wound-healing activities is shown [5].…”