Investigation of commercial mitolife as an antioxidant and antimutagen

Weisburger, John H.; Hosey, James; Larios, Eric; Pittman, Brian; Zang, Edith; Hara, Yukihiko; Kuts-Cheraux, Gerald

doi:10.1016/s0899-9007(00)00557-8

Cited by 18 publications

(5 citation statements)

References 22 publications

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“…Annona senegalensis has been reported to contain low level of tannins, catechin but high in fiber [26] and it has been indicated that the growth of broiler chicks had a negative relationship with dietary tannin contents of green tea [27]. This results therefore confirms this assertion in the sense that, the low tannin level in both the Annona and the garlic reflect in the good performance observed in this study.…”

Section: Discussionsupporting

confidence: 88%

Untitled

2022

AROC in Agric

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Section: Discussionsupporting

confidence: 88%

Untitled

2022

AROC in Agric

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“…2-AA and 4NQO are genotoxic carcinogens of which the toxic actions are believed to be mediated by the generation of reactive oxygen species. 5,6) It is possible that the toxic action of 2-AA and 4NQO in paramecia is due to the formation of reactive oxygen species. It has been reported that BisPhA has estrogen-like effects in bird embryos.…”

Section: Ic 50 Values For Organic Solvents Carcinogens Mutagens Anmentioning

confidence: 99%

Use of Paramecium Species in Bioassays for Environmental Risk Management: Determination of IC50 Values for Water Pollutants

Miyoshi

Kawano

Tanaka

et al. 2003

JOURNAL OF HEALTH SCIENCE

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Effect of chemical water pollutants on the growth of two Paramecium species (Paramecium caudatum and Paramecium trichium) were examined. The chemicals used as model chemical pollutants include organic solvents, potential carcinogens, mutagens, metabolic modulators, herbicides, insecticides, fungicides, antimicrobials, heavy metals, and heavy metal-containing chemicals. In this study, the IC 50 values indicating the concentration of substances inhibiting the proliferation of Paramecium cells by 50% were used instead of the LD 50 value, which indicates the dose of substances killing half the population of organisms, since the former is a more sensitive parameter for assessing the toxicity of substances at lower concentrations. Among 25 chemicals examined, di-(2-ethylhexyl)phthalate, potassium dichromate, 2,4-dichlorophenoxy acetic acid, and paraquat stimulated the growth of paramecia depending on the concentrations used. Dimethyl sulfoxide and formaldehyde were shown to be inert to paramecia in the range of concentrations (up to 1%, v/v) used here. Other chemicals were shown to inhibit the growth of the paramecia and thus the IC 50 values for those chemicals were determined. Our data presented here may be a useful reference for assessing the impact of water pollutants on aqueous microecosystems consisting of various microorganisms including protozoa.

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“…Green tea polyphenols (GTP) are catechol and its metamer compounds extracted from green tea. It has been proved that GTP had antioxidation (Weisburger et al, 2001), deodorization (Terada et al, 1993), sterilization (Ryu, 1980;Hong et al, 2004) and pharmacological effects (Villiers et al, 1998). Effects of GTP on increasing Lactobacilli count and decreasing Bacteroidaceae count in chicken caecal contents (Terada et al, 1993) and porcine feces (Hara et al, 1995) have been reported.…”

Section: Introductionmentioning

confidence: 99%

Effects of Green Tea Polyphenols and Fructo-oligosaccharides in Semi-purified Diets on Broilers` Performance and Caecal Microflora and Their Metabolites

Cao¹,

Karasawa²,

Guo³

2005

Asian Australas. J. Anim. Sci

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This study was conducted to examine the effects of green tea polyphenols (GTP) and fructo-oligosaccharides (FOS) supplement on performance, counts of caecal microflora and its metabolites production. In female broiler chickens fed on semi-purified diets from 28 to 42 d of age, dietary green tea polyphenols (GTP) and fructo-oligosaccharides (FOS) significantly reduced mortality (p<0.05). Dietary GTP significantly decreased the total count of caecal microflora, each colonic population count and caecal flora metabolites contents when compared to other groups (p<0.05). Dietary FOS did not influence the total count of caecal flora but it selectively increased Bifidobacteri and Eubacteria counts (p<0.05) and decreased the count of other microflora and concentrations of caecal phenols and indole (p<0.0.5). These results suggest that GTP and FOS in semi-purified diets can decrease mortality and change the caecal colonic flora population, but GTP shows antibiotic-like effects of non-selectively decreasing all colonic flora and then metabolites, and FOS acts selectively by increasing profitable microflora and decreasing production of caecal microflora metabolites besides volatile fatty acids.

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Investigation of commercial mitolife as an antioxidant and antimutagen

Cited by 18 publications

References 22 publications

Untitled

Untitled

Use of Paramecium Species in Bioassays for Environmental Risk Management: Determination of IC50 Values for Water Pollutants

Effects of Green Tea Polyphenols and Fructo-oligosaccharides in Semi-purified Diets on Broilers` Performance and Caecal Microflora and Their Metabolites

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