Investigation of colorectal cancer by minimal preparation CT in the frail and elderly patient

Saunders, John K.; Bowman, C R; Panto, Philip N.; Menon, Ashvini

doi:10.1136/gut.2011.239301.151

Cited by 1 publication

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“…Some 79 per cent of patients in the single-FIT cohort underwent colonoscopy and 21 per cent CT, whereas fewer patients underwent colonoscopy in the double-FIT cohort (53 per cent) than colonic imaging (47 per cent). Although decreased colonoscopy may have reduced adenoma detection in the double-FIT cohort, colorectal cancer detection using CT has been shown to be equivalent to that for colonoscopy 13,14 .…”

Section: Resultsmentioning

confidence: 96%

Double faecal immunochemical testing in patients with symptoms suspicious of colorectal cancer

Gerrard

Maeda

Miller

et al. 2023

British Journal of Surgery

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Background Faecal immunochemical test (FIT)-directed pathways based on a single test have been implemented for symptomatic patients. However, with a single test, the sensitivity is 87 per cent at 10 µg haemoglobin (Hb) per g faeces. This aims of this study were to define the diagnostic performance of a single FIT, compared with double FIT in symptomatic populations. Methods Two sequential prospective patient cohorts referred with symptoms from primary care were studied. Patients in cohort 1 were sent a single FIT, and those in cohort 2 received two tests in succession before investigation. All patients were investigated, regardless of having a positive or negative test (threshold 10 µg Hb per g). Results In cohort 1, 2260 patients completed one FIT and investigation. The sensitivity of single FIT was 84.1 (95 per cent c.i. 73.3 to 91.8) per cent for colorectal cancer and 67.4 (61.0 to 73.4) per cent for significant bowel pathology. In cohort 2, 3426 patients completed at least one FIT, and 2637 completed both FITs and investigation. The sensitivity of double FIT was 96.6 (90.4 to 99.3) per cent for colorectal cancer and 83.0 (77.4 to 87.8) per cent for significant bowel pathology. The second FIT resulted in a 50.0 per cent reduction in cancers missed by the first FIT, and 30.0 per cent for significant bowel pathology. Correlation between faecal Hb level was only modest (rs = 0.58), and 16.8 per cent of double tests were discordant, 11.4 per cent in patients with colorectal cancer and 18.3 per cent in those with significant bowel pathology. Conclusion FIT in patients with high-risk symptoms twice in succession reduces missed significant colorectal pathology and has an acceptable workload impact.

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Section: Resultsmentioning

confidence: 96%