Investigation of chromosome 17 candidate genes in susceptibility to TB in a South African population

“…There was no statistically significant difference in the distribution of MCP1 genotypes between HD patients without CVD and healthy controls. 7 In the study by Park et al 15 on Korean subjects, the promoter polymorphism of MCP1 (MCP1 -2518G>A) was involved in HBV clearance, which is associated with the development of antibodies to surface antigen of HBV (anti-HBs): the frequency of homozygotes for the MCP1 -2518A allele among chronic HBV carriers was significantly higher than that among spontaneously recovered subjects. However, a year later, Cheong et al 16 did not demonstrate an association of MCP1 -2518G>A with the outcome of HBV infection in Korean patients.…”

mentioning

confidence: 99%

Polymporphism of monocyte chemoattractant protein 1 (MCP1 –2518 A/G) and responsiveness to hepatitis B vaccination in hemodialysis patients

Grzegorzewska¹,

Pajzderski²,

Sowińska³

et al. 2013

Polish Archives of Internal Medicine

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“…However, in vivo evidence suggests some protective role for iNOS in human tuberculosis (TB). Genome-wide association studies link NOS2 with an increased incidence of TB (4)(5)(6)(7)(8), although the expression and/or activity of iNOS resulting from these polymorphisms are unknown. Still other investigators reported that iNOS and NO production in TB patients correlates with less severe disease, and NO production by human alveolar MFs ex vivo inhibits mycobacterial growth (9)(10)(11)(12)(13)(14)(15).…”

mentioning

confidence: 99%

Differential Requirements for l-Citrulline and l-Arginine during Antimycobacterial Macrophage Activity

Rapovy¹,

Zhao²,

Bricker³

et al. 2015

The Journal of Immunology

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Microbicidal NO production is reliant on inducible NO synthase–mediated l-arginine metabolism in macrophages (MΦs). However, l-arginine supply can be restricted by arginase activity, resulting in inefficient NO output and inhibition of antimicrobial MΦ function. MΦs circumvent this by converting l-citrulline to l-arginine, thereby resupplying substrate for NO production. In this article, we define the metabolic signature of mycobacteria-infected murine MΦs supplied l-arginine, l-citrulline, or both amino acids. Using liquid chromatography–tandem mass spectrometry, we determined that l-arginine synthesized from l-citrulline was less effective as a substrate for arginase-mediated l-ornithine production compared with l-arginine directly imported from the extracellular milieu. Following Mycobacterium bovis bacillus Calmette–Guérin infection and costimulation with IFN-γ, we observed that MΦ arginase activity did not inhibit production of NO derived from l-citrulline, contrary to NO inhibition witnessed when MΦs were cultured in l-arginine. Furthermore, we found that arginase-expressing MΦs preferred l-citrulline over l-arginine for the promotion of antimycobacterial activity. We expect that defining the consequences of l-citrulline metabolism in MΦs will provide novel approaches for enhancing immunity, especially in the context of mycobacterial disease.

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Investigation of chromosome 17 candidate genes in susceptibility to TB in a South African population

Cited by 51 publications

References 46 publications

Heparin-Binding Hemagglutinin Induces IFN-γ⁺IL-2⁺IL-17⁺Multifunctional CD4⁺T Cells during Latent but Not Active Tuberculosis Disease

Heparin-Binding Hemagglutinin Induces IFN-γ⁺IL-2⁺IL-17⁺Multifunctional CD4⁺T Cells during Latent but Not Active Tuberculosis Disease

Polymporphism of monocyte chemoattractant protein 1 (MCP1 –2518 A/G) and responsiveness to hepatitis B vaccination in hemodialysis patients

Differential Requirements for l-Citrulline and l-Arginine during Antimycobacterial Macrophage Activity

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Investigation of chromosome 17 candidate genes in susceptibility to TB in a South African population

Cited by 51 publications

References 46 publications

Heparin-Binding Hemagglutinin Induces IFN-γ+IL-2+IL-17+Multifunctional CD4+T Cells during Latent but Not Active Tuberculosis Disease

Heparin-Binding Hemagglutinin Induces IFN-γ+IL-2+IL-17+Multifunctional CD4+T Cells during Latent but Not Active Tuberculosis Disease

Polymporphism of monocyte chemoattractant protein 1 (MCP1 –2518 A/G) and responsiveness to hepatitis B vaccination in hemodialysis patients

Differential Requirements for l-Citrulline and l-Arginine during Antimycobacterial Macrophage Activity

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Product

Resources

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Heparin-Binding Hemagglutinin Induces IFN-γ⁺IL-2⁺IL-17⁺Multifunctional CD4⁺T Cells during Latent but Not Active Tuberculosis Disease

Heparin-Binding Hemagglutinin Induces IFN-γ⁺IL-2⁺IL-17⁺Multifunctional CD4⁺T Cells during Latent but Not Active Tuberculosis Disease