Investigation of Chromatographic Performance of Hyperbranched Amine-Modified Stationary Phases in Ion Chromatography

Kawase, Itsuya; Lim, Lee Wah; Takeuchi, Toyohide

doi:10.15583/jpchrom.2016.018

Cited by 6 publications

(5 citation statements)

References 21 publications

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“…Development of novel stationary phases has been regarded as a key approach to create more efficient and cost-effective separations in chromatography. In fact, various types of new stationary phases have been developed in liquid chromatography (LC) [1][2][3][4][5][6][7][8][9][10], however there is a still long way to get the final systematic interpretation of the whole LC retention mechanism.…”

Section: Introductionmentioning

confidence: 99%

Retention Behavior of Polycyclic Aromatic Compounds in a Novel Polymer-Based Stationary Phase Liquid Chromatography

et al. 2018

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A novel polymer-based particles was introduced as a stationary phase in liquid chromatography (LC). Spherical particles of a copolymer, poly(benzoguanamine-co-formaldehyde) (BF), was packed into a conventional blank LC column and the retention behavior of polycyclic aromatic compounds (PACs) was evaluated in reversed-phase LC. The trend for the retention was compared with that obtained on commercially-available octadecylsilica (ODS) and phenylbutylsilica (PBS) phases. In terms of the trend on the retentivity for PACs, the BF phase showed a similar behavior as that on the ODS phase, although the selectivity to some critical pairs was somewhat different from that on the ODS phase. The results suggest that the BF phase has a retentivity basically on the basis of hydrophobic interaction between the stationary phase ligands and the solute molecule, however, at the same time, the BF phase has a different selectivity from the PBS phase for the recognition of PACs molecules. On the basis of the comparison with the PBS phase, the unique selectivity of the BF phase can be attributed to the restricted moving of the phenyl ligands.

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Section: Introductionmentioning

confidence: 99%

Retention Behavior of Polycyclic Aromatic Compounds in a Novel Polymer-Based Stationary Phase Liquid Chromatography

et al. 2018

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“…In order to achieve effective separation for various types of complex sample mixtures in LC measurements, appropriate separation conditions must be chosen. In particular, an appropriate choice of stationary phase is quite important [8][9][10][11][12]. Octadecylsilica (ODS) is the most popular stationary phase in reversed-phase (RP) LC owing to its good separation performance for various complex sample mixtures [13][14][15][16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Fibrous Polyimide Stationary Phase for the Separation of Aromatic Compounds in Reversed-Phase Liquid Chromatography

NAKAGAMI,

YAMAGUCHI,

KONO

et al. 2024

Chromatography

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A novel fiber-packed column was developed with a fibrous polyimide (PI) as the separation medium in liquid chromatography (LC), and the retention behavior for various aromatic compounds on the stationary phase was investigated in reversed-phase conditions. A retention trend was observed on the PI phase, which strongly retained certain types of analytes with long alkyl chain(s) in the chemical structure. However, the retention factor of analytes with short alkyl chains exceeded that expected from hydrophobic interaction between the analytes and stationary phase. Several solute pairs with and without polar functional groups were employed as the sample probe. The separation factor for these analyte pairs on the PI phase was significantly better than that on typical conventional stationary phases such as octadecylsilica phases. The fibrous PI stationary phase exhibited a unique retention tendency in that the retention time of toluene increased with an increase in the column temperature, and the trends differed from that observed on typical LC stationary phases.

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“…Poly(ethylene oxide)-bonded stationary phase was successfully prepared by chemically bonded with aminopropylsilica for anions separation by ion-exchange mode [3][4][5]. Kawase et al, have prepared a hyperbranched amine-modified capillary column by reacting aminopropylsilica with diepoxidemodification and ammonia repeatedly for separation of iodide, nitrate, and iodate, as well as hydrophobic compounds [6]. Kisiliva et al, have modified the silica particles with [3-(phenylamino)propyl] trimethoxysilane in toluene for separation of phenols [7] and separation of anions using conductivity detector [8].…”

Section: Introductionmentioning

confidence: 99%

One-pot Facile Preparation of Amino-functionalized Silica Hybrid Monoliths for Mixed-mode Chromatography

2019

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Silica hybrid monolithic columns were prepared using two precursors, in which organo-functionalized trialkoxysilanes are mixed with tetraalkoxysilanes. In this study, several types of amino-functionalized silica hybrid monolithic columns were prepared via single-step "one-pot" approach, and the amount of silica precursors, porogens, as well as the reaction conditions were optimized. The preparation was carried out by mixing the silica precursors, i.e. tetraethoxysilane (TEOS) or tetramethoxysilane (TMOS) with amino precursors such as aminopropyltrimethoxysilane (APTES), aminoethylaminopropyl-trimethoxysilane (AEAPTMS), and phenylaminopropyltrimethoxysilane (PAPTMS) in a porogenic solution. The chromatographic performance of these hybrid monolithic columns was optimized by investigating several parameters through the separation of inorganic anions (IO3 -, BrO3 -, Br -, NO2 -, NO3 -, I -, SCN -) and some polar compounds (thymine, thymidine, adenosine, adenine, uridine). Results showed that the silica hybrid monolithic columns could be operated at higher flow-rate that favors rapid separation. The run-to-run repeatability of Si-APTES and Si-PAPTMS hybrid monolithic columns were satisfactory with relative standard deviations (n = 5) of less than 8% for all the analyte anions.Amino-functionalized silica precursors was used in the preparation of hybrid monolithic column to reduce the preparation time via one-pot approach. The amine groups in the structure can provide weak anion exchange interaction and also hydrophilic interaction. The synthesized hybrid monolithic columns revealed good mechanical stability and good separation repeatability.

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Investigation of Chromatographic Performance of Hyperbranched Amine-Modified Stationary Phases in Ion Chromatography

Cited by 6 publications

References 21 publications

Retention Behavior of Polycyclic Aromatic Compounds in a Novel Polymer-Based Stationary Phase Liquid Chromatography

Retention Behavior of Polycyclic Aromatic Compounds in a Novel Polymer-Based Stationary Phase Liquid Chromatography

Fibrous Polyimide Stationary Phase for the Separation of Aromatic Compounds in Reversed-Phase Liquid Chromatography

One-pot Facile Preparation of Amino-functionalized Silica Hybrid Monoliths for Mixed-mode Chromatography

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