Abstract:Quantitative and qualitative nature of chemical noise propagation in biochemical reaction networks depend crucially on the topology of the networks. Multisite reversible phosphorylation-dephosphorylation of target proteins is one such recurrently found topology that regulates host of key functions in living cells. Here we analytically calculated the stochasticity in multistep reversible chemical reactions by determining variance of phosphorylated species at the steady state using linear noise approximation to … Show more
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