Investigation of changes in the activity and function of dry eye-associated brain regions using the amplitude of low-frequency fluctuations method

Sun, Tie; Shu, Hui‐Ye; Wu, Jieli; Su, Ting; Liu, Yu-Ji; Zhang, Lijuan; Li, Qiuyu; Pan, Yi‐Cong; Ge, Qian‐Min; Shao, Yi

doi:10.1042/bsr20210941

Cited by 5 publications

(3 citation statements)

References 37 publications

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“…Thus, for dry eye to be defined with the greatest degree of precision and to be distinguished from other ocular surface disorders, the etiological factors are essential. In addition, the symptoms dry eye syndrome are associated with malfunction in particular brain regions [ 31 ]. In addition, gut microbiome disturbance or dysbiosis was identified to be associated with the development of dry eye, particularly primary Sjogren’s disease ( Figure 1 ) [ 32 ].…”

Section: Chronic Eye Diseases That Require Long-acting Therapymentioning

confidence: 99%

Recent Advances of Ocular Drug Delivery Systems: Prominence of Ocular Implants for Chronic Eye Diseases

et al. 2023

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Chronic ocular diseases can seriously impact the eyes and could potentially result in blindness or serious vision loss. According to the most recent data from the WHO, there are more than 2 billion visually impaired people in the world. Therefore, it is pivotal to develop more sophisticated, long-acting drug delivery systems/devices to treat chronic eye conditions. This review covers several drug delivery nanocarriers that can control chronic eye disorders non-invasively. However, most of the developed nanocarriers are still in preclinical or clinical stages. Long-acting drug delivery systems, such as inserts and implants, constitute the majority of the clinically used methods for the treatment of chronic eye diseases due to their steady state release, persistent therapeutic activity, and ability to bypass most ocular barriers. However, implants are considered invasive drug delivery technologies, especially those that are nonbiodegradable. Furthermore, in vitro characterization approaches, although useful, are limited in mimicking or truly representing the in vivo environment. This review focuses on long-acting drug delivery systems (LADDS), particularly implantable drug delivery systems (IDDS), their formulation, methods of characterization, and clinical application for the treatment of eye diseases.

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Section: Chronic Eye Diseases That Require Long-acting Therapymentioning

confidence: 99%

Recent Advances of Ocular Drug Delivery Systems: Prominence of Ocular Implants for Chronic Eye Diseases

et al. 2023

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“…The ALFF measures the low-frequency oscillation intensity of BOLD time courses in rs-fMRI (Zang et al, 2007;Guo et al, 2022). Although the exact biologic mechanisms of ALFF remain unclear, plenty of research has indicated that the ALFF changes are associated with local neuronal activity (Cui et al, 2017;Wang et al, 2019;Sun et al, 2022). ReHo measures the similarity in the time series of a given voxel to its nearest neighbors, which indicates that the ReHo alterations are associated with the coherence of spontaneous neuronal activity (Zang et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Intrinsic brain abnormalities in chronic rhinosinusitis associated with mood and cognitive function

et al. 2023

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BackgroundChronic rhinosinusitis (CRS) poses a risk for developing emotional and cognitive disorders. However, the neural evidence for this association is largely unclear. Resting-state functional magnetic resonance imaging (rs-fMRI) analysis can demonstrate abnormal brain activity and functional connectivity and contribute to explaining the potential pathophysiology of CRS-related mood and cognitive alterations.MethodsChronic rhinosinusitis patients (CRS, n = 26) and gender- and age-matched healthy control subjects (HCs, n = 38) underwent resting-state functional MRI scanning. The amplitude of low-frequency fluctuations (ALFF) was calculated to observe the intrinsic brain activity. The brain region with altered ALFF was further selected as the seed for functional connectivity (FC) analysis. Correlation analysis was performed between the ALFF/FC and clinical parameters in CRS patients.ResultsCompared with HCs, CRS patients exhibited significantly increased ALFF in the left orbital superior frontal cortex and reduced connectivity in the right precuneus using the orbital superior frontal cortex as the seed region. The magnitude of the orbital superior frontal cortex increased with inflammation severity. In addition, ALFF values in the orbital superior frontal cortex were positively correlated with the hospital anxiety and depression scale (HADS) scores. The ROC curves of altered brain regions indicated great accuracy in distinguishing between CRS patients and HCs.ConclusionIn this study, patients with CRS showed increased neural activity in the orbital superior frontal cortex, a critical region in emotional regulation, and this region also indicated hypoconnectivity to the precuneus with a central role in modulating cognition. This study provided preliminary insights into the potential neural mechanism related to mood and cognitive dysfunctions in CRS patients.

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“…Additionally, higher brain functions may be involved in the onset and progression of DE symptoms [19][20][21]. We previously used menthol to investigate cold sensitivity and its association with short TBUT DE and found no difference in cold sensitivity between individuals with short TBUT DE and normal eyes.…”

Section: Introductionmentioning

confidence: 99%

Variability of autonomic nerve activity in dry eye with decreased tear stability

et al. 2022

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The autonomic nervous system plays a crucial role in the maintenance of homeostasis. Neurogenic inflammation due to decreased stability of tear film may induce changes in autonomic nerve activity, which could be associated with symptom expression.This study aimed to measure biological parameters that represent autonomic nerve activity in dry eye (DE)s caused by tear film dysfunction and investigate their relationship with symptom intensity. This prospective, cross-sectional, comparative study evaluated 34 eyes of 34 participants (mean age: 52.5 ± 13.4 years; range: 20–81 years) without keratoconjunctival damage. Nineteen eyes in the DE group showed DE symptoms and tear break-up time (TBUT) of ≤5 seconds (short TBUT DE); the 15 eyes in the non-DE group showed no DE symptoms. Autonomic nerve activity was measured for 10 minutes—starting and ending 5 minutes before and after instilling ophthalmic solution—and evaluated using the low-frequency component (LF) to the high-frequency component (HF) ratio of heart rate variability (autonomic balance). The pre-ophthalmic solution administration LF/HF ratio was not significantly different (P = 0.59) between the two groups, however, the standard deviation of the LF/HF ratio (LF/HF-SD) tended to be higher in the DE group than that in the non-DE group (P = 0.086). The DE symptom intensity was significantly related to LF/HF-SD (P = 0.005), which significantly decreased after ophthalmic solution administration in the DE group (P = 0.04). The large fluctuations in autonomic balance may be key for the understanding of the mechanism underlying DE symptoms.

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Investigation of changes in the activity and function of dry eye-associated brain regions using the amplitude of low-frequency fluctuations method

Cited by 5 publications

References 37 publications

Recent Advances of Ocular Drug Delivery Systems: Prominence of Ocular Implants for Chronic Eye Diseases

Recent Advances of Ocular Drug Delivery Systems: Prominence of Ocular Implants for Chronic Eye Diseases

Intrinsic brain abnormalities in chronic rhinosinusitis associated with mood and cognitive function

Variability of autonomic nerve activity in dry eye with decreased tear stability

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