Investigation of cell free BIRC5 mRNA as a serum diagnostic and prognostic biomarker for colorectal cancer

Wang, Haiyan; Zhang, Xin; Wang, Lili; Zheng, Guixi; Li, Du; Yang, Yongmei; Dong, Zhaogang; Liu, Yimin; Qu, Ailin; Wang, Chuanxin

doi:10.1002/jso.23526

Cited by 33 publications

(22 citation statements)

References 33 publications

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“…BIRC5 is a member of the inhibitor of apoptosis protein family, which has a critical role in the occurrence and progression of tumors (52). BIRC5 has been reported to be associated with colorectal cancer tumorigenesis and progress (53). BIRC5, as a component of the chromosomal passenger complex, is involved in the microtubule-kinetochore attachment that ensures cohesion between sister chromatids and centrosome aggregation (54).…”

Section: Discussionmentioning

confidence: 99%

Identification of candidate genes that may contribute to the metastasis of prostate cancer by bioinformatics analysis

et al. 2017

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Abstract. To screen for marker genes associated with to the metastasis of prostate cancer (PCa), in silico analysis of the Gene Expression Omnibus dataset GSE27616, which included 4 metastatic and 5 localized PCa tissue samples, was performed. Differentially expressed genes (DEGs) were identified. Their potential functions were identified by Gene Ontology and Kyoto Encyclopedia of Gene Genomes pathway enrichment analyses. Furthermore, protein-protein interaction (PPI) networks for DEGs were constructed using Cytoscape. Module analysis of the PPI networks was performed with Cluster ONE. A total of 561 DEGs were screened, including 208 upregulated and 353 downregulated genes. Proliferating cell nuclear antigen (PCNA) and cluster of differentiation 4 (CD4) exhibited the highest degrees of connectivity in the PPI networks for up-and down-regulated DEGs, respectively. The DEGs in module A, including CD58, 2, 4 and major histocompatibility complex, class II DP-β1 were enriched in 'cell adhesion molecules'. Anaphase promoting complex subunit 4, cell division cycle 20 and cell division cycle 16 in module B were primarily enriched in 'cell cycle'. The DEGs, including CD4, PCNA and baculoviral IAP repeat containing 5, may have critical roles in PCa metastasis and could thus be used as novel biomarker candidates for metastatic PCa. However, further studies are required to verify these results.

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Section: Discussionmentioning

confidence: 99%

Identification of candidate genes that may contribute to the metastasis of prostate cancer by bioinformatics analysis

et al. 2017

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“…As a mitotic spindle checkpoint gene, baculoviral inhibitor of apoptosis repeat containing 5 (BIRC5, also known as survivin) has been shown to play vital roles in carcinogenesis by influencing cell division and proliferation and by inhibiting apoptosis [4]. Since BIRC5 is frequently overexpressed in a majority of malignancies [5][6][7], treatment that targets BIRC5 has been increasingly noticed as a novel strategy for various malignant tumors. For example, inactivation of nuclear export signal for BIRC5 may increase therapy response in head and neck cancer patients [8].…”

Section: Introductionmentioning

confidence: 99%

Identification of prognostic significance of BIRC5 in breast cancer using integrative bioinformatics analysis

et al. 2020

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Aims: Baculoviral inhibitor of apoptosis repeat containing 5 (BIRC5) plays vital roles in carcinogenesis by influencing cell division and proliferation and by inhibiting apoptosis. However, the prognostic significance of BIRC5 remains unclear in breast cancer. Methods: BIRC5 expression and methylation status were evaluated using the Oncomine and The Cancer Genome Atlas (TCGA) databases. The relevance between BIRC5 and different clinicopathological features as well as survival information was analyzed using the bc-GenExMiner database and Kaplan-Meier Plotter. BIRC5-drug interaction network was obtained using the Comparative Toxicogenomics Database. Results: Based on the results from databases and own hospital data, BIRC5 was higher expressed in different breast cancer subtypes compared with the matched normal individuals. Hormone receptors were negatively correlated with BIRC5 expression, whereas the Scarff-Bloom-Richardson (SBR) grade, Nottingham Prognostic Index (NPI), human epidermal growth factor receptor-2 (HER-2) status, basal-like status, and triple-negative status were positively related to BIRC5 level in breast cancer samples with respect to normal tissues. High BIRC5 expression was responsible for shorter relapse-free survival, worse overall survival, reduced distant metastasis free survival, and increased risk of metastatic relapse event. BIRC5-drug interaction network indicated that several common drugs could modulate BIRC5 expression. Furthermore, a positive correlation between BIRC5 andcell-division cycle protein 20 (CDC20) gene was confirmed. Conclusion: BIRC5 may be adopted as a promising predictive marker and potential therapeutic target in breast cancer. Further large-scale studies are needed to more precisely confirm the value of BIRC5 in treatment of breast cancer.The Breast Cancer Gene-Expression Miner v4.1 (bc-GenExMiner v4.1, http://bcgenex.centregauducheau.fr/BC-GEM), an open access database of published annotated genomics data, was utilized to analyze the relevance between BIRC5 and specific clinicopathological features of breast cancer [16,17]. Association between BIRC5 and metastatic relapse event was assessed using the prognostic module, and correlation of BIRC5 and co-expressed cell-division cycle protein 20 (CDC20) was evaluated using the correlation module. UCSC XenaThe UCSC Xena browser (http://xena.ucsc.edu/) was used to analyze the TCGA Breast Cancer data using the level 3 data. The heatmap and correlation between BIRC5 and CDC20 were then constructed. Kaplan-Meier PlotterThe Kaplan-Meier Plotter (http://kmplot.com/analysis/), a web tool capable to check the effect of 54675 genes on survival using 5143 clinical breast cancer samples, was applied to show the prognostic value of BIRC5 in relapse-free survival, overall survival, and distant metastasis-free survival [18]. The hazard ratio (HR) with 95% confidence interval (CI), and log-rank P-value were calculated automatically.

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“…Previous studies have demonstrated that survivin, unlike other IAPs, is strongly expressed in the majority of neoplasms. Overexpression of survivin is also significantly correlated with a poor prognosis and decreased survival rates in breast and lung cancer, colon, bladder and Ewing sarcoma, and lymphomas (2)(3)(4)(5)(6)(7). BIRC5/survivin is an essential protein involved in Ewing sarcoma cell growth and proliferation (7).…”

Section: Introductionmentioning

confidence: 99%

Association between functional variants in BIRC5/survivin gene 3′ untranslated region and mRNA expression in lymphoblastoid cell lines

Shao

Yang

et al. 2015

Oncology Letters

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Investigation of cell free BIRC5 mRNA as a serum diagnostic and prognostic biomarker for colorectal cancer

Abstract: Serum cell free BIRC5 mRNA is a promising non-invasive biomarker for diagnosis and prognosis of CRC.

Cited by 33 publications

References 33 publications

Identification of candidate genes that may contribute to the metastasis of prostate cancer by bioinformatics analysis

Identification of candidate genes that may contribute to the metastasis of prostate cancer by bioinformatics analysis

Identification of prognostic significance of BIRC5 in breast cancer using integrative bioinformatics analysis

Association between functional variants in BIRC5/survivin gene 3′ untranslated region and mRNA expression in lymphoblastoid cell lines

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