Investigation of CCL1 rs159294 T/A gene polymorphism in pulmonary and extrapulmonary tuberculosis patients

Özdemir, Fethi Ahmet; Erol, Deniz; Yüce, Hüseyin; Konar,; E, Kara Şenli; Bulut, Funda; Deveci, Figen

doi:10.5578/tt.5481

Cited by 2 publications

(2 citation statements)

References 14 publications

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“…Further supporting this notion, Thuong et al also found a genetic association between variants in the CCL1 region and TB susceptibility 77 . However to date, subsequent genetic association studies investigating CCL1 have reported mixed results 78 79 .…”

Section: Discussionmentioning

confidence: 99%

Mycobacterial infection induces a specific human innate immune response

Blischak

Tailleux

Mitrano

et al. 2015

Sci Rep

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Section: Discussionmentioning

confidence: 99%

Mycobacterial infection induces a specific human innate immune response

Blischak

Tailleux

Mitrano

et al. 2015

Sci Rep

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show abstract

“…Further supporting this notion, Thuong et al also found a genetic association between variants in the CCL1 region and TB susceptibility [44]. However to date, subsequent genetic association studies investigating CCL1 have reported mixed results [45,46].…”

Section: Bayesian Analysis Identified Mycobacteria-specific Response mentioning

confidence: 90%

Mycobacterial infection induces a specific human innate immune response

Blischak

Tailleux

Mitrano

et al. 2015

Preprint

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The innate immune system provides the first response to infection and is now recognized to be partially pathogen-specific. Mycobacterium tuberculosis (MTB) is able to subvert the innate immune response and survive inside macrophages. Curiously, only 5-10% of otherwise healthy individuals infected with MTB develop active tuberculosis (TB). We do not yet understand the genetic basis underlying this individual-specific susceptibility. Moreover, we still do not know which properties of the innate immune response are specific to MTB infection. To identify immune responses that are specific to MTB, we infected macrophages with eight different bacteria, including different MTB strains and related mycobacteria, and studied their transcriptional response. We identified a novel subset of genes whose regulation was affected specifically by infection with mycobacteria. This subset includes genes involved in phagosome maturation, superoxide production, response to vitamin D, macrophage chemotaxis, and sialic acid synthesis. We suggest that genetic variants that affect the function or regulation of these genes should be considered candidate loci for explaining TB susceptibility.The innate immune system provides the first line of defense against microbial pathogens. Broadly speaking, innate immune cells recognize foreign molecules through pattern recognition receptors (PRRs), e.g. Toll-like receptors (TLRs), which bind to highly-conserved pathogenic motifs known as pathogen-associated molecular patterns (PAMPs) 1,2 . In addition, innate immune cells recognize damage-associated molecular patterns (DAMPs) of host molecules released by infected cells 3 . The initial innate response involves the release of proinflammatory cytokines and lipids to recruit and activate other immune cells, phagocytosis of the pathogen, and apoptosis 4 . If the infection persists, the phagocytes stimulate the adaptive immune system by presenting antigens to activate T and B cells. In contrast to the highly specific adaptive immune response, the innate immune response has traditionally been viewed as a general response to infection.Yet, more recent work revealed that the innate immune system also produces a pathogen-specific response in addition to the general response [5][6][7][8] . Furthermore, this pathogen-specific innate response can in turn affect the specificity of the adaptive immune response by directing the differentiation of T cells into distinct subtypes 9 . That said, though we developed an appreciation for the importance of the specific innate immune response, we still do not know the extent to which the innate immune response differs between infections nor fully understand the consequences of specific innate immune responses for fighting pathogens. One of the first challenges is to distinguish the unique immune response to a specific pathogen from the large core more general response.The pathogen-specific innate immune response is determined, at least in part, by the specificity of the PRRs of the host immune cell. Each PRR binds to its s...

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Investigation of CCL1 rs159294 T/A gene polymorphism in pulmonary and extrapulmonary tuberculosis patients

Abstract: CCL1 rs159294 T/A polymorphism do not form an inclination to tuberculosis in our population.

Cited by 2 publications

References 14 publications

Mycobacterial infection induces a specific human innate immune response

Mycobacterial infection induces a specific human innate immune response

Mycobacterial infection induces a specific human innate immune response

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